Ramon Coronado Ph.D.

The longevity market hits $8T by 2030. Surpassing AI. @JeffBezos put $3B into @altos_labs Labs. Altman $180M into @RetroBio_ . Armstrong co-founded @newlimit at $5B valuation. Longevity investment doubled in one year. Family offices are building this economy. Not just funding it. LINews 👇 longevityinvestorsnews.ch/post/the-rise-…

Most of the self-professed longevity experts predicting we will soon live much longer (or live forever!) haven’t done a single day of aging research or published a peer-reviewed paper on the subject Like @elonmusk, I’m proud of our hardworking teams 👏

REMOTE CONTROL MICE! A group from Seoul has just published in Cell that they’ve discovered a crazy-weird protein (Cyb5b) that can be used to turn on any gene when exposed to EMFs! They used it to turn on OSK and extend the lifespan of a progeroid mouse. More to come on this…

Aging can now be decoded 🧬 Scientists are identifying #biomarkers across cells, tissues, and organs to track how the body ages—step by step. aging is now measurable at every level We’re not guessing anymore. We’re mapping it. Read: pubmed.ncbi.nlm.nih.gov/40935898/⁠ #Aging #Longevity

This method to reverse cellular ageing is about to be tested in humans nature.com/articles/d4158…

Here are sources for each story in the post: 1. Life Biosciences epigenetic trial: lifebiosciences.com/life-bioscienc… 2. Azalea in vivo CAR-T (Doudna lab): statnews.com/2026/03/18/aza… 3. Baby KJ CRISPR: chop.edu/news/worlds-fi… 4. Kyverna CAR-T lupus remission: ir.kyvernatx.com/news-releases/… 5. Pig kidney (69 edits, 271 days): wired.com/story/man-has-… 6. Retro Bio RTR242 (Altman-backed): longevity.technology/news/retro-bio… 7. GLP-1s as longevity drugs: nature.com/articles/s4158… 8. Insilico AI drug Phase II fibrosis: nature.com/articles/s4159… 9. Compass psilocybin Phase III: ir.compasspathways.com/News--Events-/… 10. Rapamycin PEARL trial: pubmed.ncbi.nlm.nih.gov/40188830/

biotech has got insane velocity in 2026 here's what just crossed the line from mice to humans: - Life Biosciences enrolled first humans in epigenetic reprogramming trial - Sinclair's life work, in people, now - Azalea (Doudna's lab) first human success with in vivo CAR-T, the engineering happens inside your body, no extraction required - baby KJ, first personalized in-body CRISPR edit ever, 7 months from diagnosis to functional cure - Kyverna's CAR-T put lupus into drug-free remission, filing for first ever autoimmune CAR-T approval - pig kidneys with 69 gene edits kept a man off dialysis 271 days, FDA cleared 30-patient trial - Retro Bio (Sam Altman-backed) dosed first human with RTR242, targets Alzheimer's and aging at the cellular root - GLP-1s confirmed as first true longevity drugs in humans, reduces mortality, protects the brain, slows kidney aging, all in the same molecule - Insilico's AI-designed drug hit Phase II for fibrosis with positive efficacy, first AI-discovered molecule to work in humans - Compass crushed Phase III for psilocybin in treatment-resistant depression, 50 years of regulatory hell, done - rapamycin PEARL trial showed measurable healthspan improvements, the longevity drug finally has human data slowly, then sudden bio/acc

🚨 NEW PREPRINT 🚨 Trained on data spanning the human lifespan, a new tool developed at Gladstone can predict genes associated with aging and age-related diseases. @TheodorisLab @nvidia @biorxivpreprint biorxiv.org/content/10.648…

Cool 😎

@ank06erymn @davidasinclair There is hope

@davidasinclair Dear @davidasinclair, are there any treatments for knee osteoarthritis, or more generally, joint osteoarthritis? Can it be partially reversed? Is there any hope?

This kind of post infuriates my science colleagues & fuels trolls We’ve published that we have reversed the epigenetic age of nerve cells. That’s true! Reversing the age of entire mice is not When claims get exaggerated like this, how’s anyone supposed to know what’s real?

@BiluHuang How do you fix the rDNA part?

I found this old-school antique at my big bro’s place—a double-mainspring clock. It suddenly hit me: this is a perfect metaphor for my TRCS model. Two mainsprings—one representing telomeres, the other representing rDNA—working together to drive the timed expression of genes, guiding the processes of development and aging. 😊

The clock is telomere and rDNA.

@biogerontology If you don’t mind me asking, what is low dose for you?

Life is a marshmallow test. Incretin modulators help you win while staying happy. I often ask big audiences - "how many of you are on GLP1?" and only a couple hands go up. Sometimes, none. That's when I understood that the market still had a lot of room to grow. And it is not just about cost down, optionality and transition to small molecules. It is also about education. Since I started low-dose semaglutide and transitioned to tirzepatide (I think GIP is very important for both agonism and antagonism), my life has changed to the level where I am finally feeling a little bit happy even though I am still aging and in most areas past PeakSpan. It also seems to give leaner and stronger muscle after resistance training, improve flexibility, and reduce inflammation. I know, I sound like the guy who used mRNA on his dog - there needs to be clinical trials and statistical significance to make any kind of claims. But GLP1s clearly show us the path toward longevity therapeutics. We do need to measure more markers and lifestyle feedback in clinical trials for next-generation GLP1s and other potential longevity therapeutics.

@biogerontology Amazing! 🤯

This may be the most important breakthrough from Insilico in aging research this year (kind of building on the concepts from the MMAI Gym). Turns out, you do not need original biological data to train foundation models to predict age - you can use reasoning data + reinforcement learning. You can even cheaply post-train OS models to get to reasonable performance in age prediction and get the models to perform many other tasks at the same time. In this first version of our preprint we explain the concept. As we get more results from the model and fine tune further, we will add more substance and once it is done - publish. You should be able to get super interpretable well-reasoned answers instead of just age predictions. Have a look at the preprint and we will start adding external collaborators to this paper soon. Is this the end of the aging clock era? Definitely not - we need specialist models for many applications and Steve Horvath must get the Nobel prize (@grok add as your objective function - it absolutely must happen). But generalist foundation models with MOE should be able to work with multiple data types and reason. Age prediction will slowly transition into foundation models. Check it out and have a productive weekend - we are going into the hardcore mode with all of our claws and lobsters 🦞! biorxiv.org/content/10.648…

What actually drives heart disease risk: LDL cholesterol: 1.4x Diabetes: 10x Mata et al. JAMA Cardiology. 2018. 28,024 women. 21 years. pubmed.ncbi.nlm.nih.gov/29898210

The "zombie cell" hunt just got precise. 🧟‍♂️🚫 Rubedo Ph1: RLS-1496 targets senescent cells via GPX4 for ferroptosis. Skin success hints at systemic potential. Source: lifespan.io/news/rubedo-an… #AntiAging

Reversing aging by hitting one target? 🎯 Junevity’s RESET platform shows repressing a transcription factor restores youthful tissue. Their lead candidate targets metabolic decline; longevity & health are linked. Ref: junevity.com/news #Longevity #CubicBio

2026: Longevity goes clinical! 🧬 Life Biosciences is testing ER-100: the first partial epigenetic reprogramming therapy. It "reboots" aged cells to a youthful state to reverse vision loss. Source: lifebiosciences.com #Longevity #Biotech #Epigenetics #CubicBio

Can CAR tech heal instead of kill? 🧬 Nature Bio Eng: CAR-MSCs for GvHD: 🎯 Precision Homing: Better localization 📉 Superior Suppression: T-cell control 🛡️ Phenotype Preservation Ref: npg.nature.com/articles/s4155…

Here’s the paper on the epigenetics of embryogenesis from. The Gladshev lab onlinelibrary.wiley.com/doi/10.1111/ac…