@manjuggm @pashtoonkasi @jonathanloree @IbrahimSahinMD1 Also with 5-FU. Confirmed on FDA/ASHP shortage websites…
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Daniel Ahn
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@manjuggm @pashtoonkasi @jonathanloree @IbrahimSahinMD1 Not a rumor, there is a national shortage. We were informed several weeks ago, specifically in 500mg tabs.
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Hearing rumors of a capecitabine shortage.. Can someone give more details? How bad is it? How long is it likely to last? Thanks!
#GIOncology @pashtoonkasi @jonathanloree @IbrahimSahinMD1
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@DucreuxMichel pubmed.ncbi.nlm.nih.gov/30508156/ . @KoheiShitara REVERCE2 ongoing to confirm findings in US patients. 3. Similar studies have shown similar OS results . BACCI (jamanetwork.com/journals/jaman…) @GIcancerDoc . 4. Why was SOLSTICE negative? TAS102/bev vs cape?
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@DucreuxMichel After having time to think about the results, don’t believe the hype. The discussant failed to mention 3 key points. 1. Is this a bev naive effect (~30% had no prior bev exposure). 2 is this a sequencing effect? Rego has shown better OS when given in third line therapy (1/3)
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NAPOLI-3 positive. Historical retrospective data suggests no difference in survival between FOLFIRINOX and gem abraxane. Maybe naliri isn’t the same as iri? Looking forward to see data. @GIcancerDoc ipsen.com/us/blog/press-…
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It was awesome sharing the stage with #PancreaticCancer superstar @KReissMD in Orlando at APA meeting … made some friends 🐊 along the way … missed @EileenMOReilly by 2 days although had the opportunity to connect with her in Chicago @ALLIANCE_org meeting !
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Trade: Detroit is dealing TE T.J. Hockenson in its division, to the Minnesota Vikings, per sources.
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@R_Brauninger That’s the take home? Should be: 1. O line is terrible, Aki needs to take a seat permanently on the bench. 2. Jimbo needs an OC and 3. Jimbo needs an OC. Play call, time management (wasted two timeouts in the second half).
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Kids played extremely hard. A bunch of those young kids grew up a lot tonight.
Let’s see what happens in a couple of weeks.
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Glad to see that Dr. @Jcj84Jeremy now has a site open for OBERTO 301 in Jacksonville, FL
Safety and Activity of PolyPEPI1018 Plus Atezolizumab in Colorectal Cancer.
NCT05243862
clinicaltrials.gov/ct2/show/NCT05…
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"Of the 5 patients who received at least 2-doses of the vaccine, 3 experienced Stable Disease & 2 had unexpected tumor size reduction of whom one patient experienced complete tumor shrinkage on two of three target lesions & partial response on one lesion."
precisionvaccinations.com/treos-bio-poly…
A.n.n.@fireflyann
Counting down My Top 10 Clinical Trials of 2018. OBERTO a Phase 1 trial - PolyPEPI1018 Vaccine in the Treatment of Metastatic Colorectal Cancer. Opened w/ 10 spots, expanded to 15. #CRCtrials #CRCSM #colorectal clinicaltrials.gov/ct2/show/NCT03…
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Thank you for the opportunity to speak at this event for this great endeavor! @GIcancerDoc @MayoCancerCare
A.n.n.@fireflyann
Next up at @KRASKickers Connect Patient conference today. Targeting KRAS: From the “Undruggable” to Druggable in Colorectal Cancer Daniel Ahn, D.O. , M.S. , Mayo Clinic @the_danielahn @MayoClinic
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As an oncology fellow, I got used to friday 5pm acute leuk consults. This past Friday was much happier trip to the hospital. Introducing Nadeem Alexander Jurdi 👶😍
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@MarkYarchoan @graokane Sounds like from the press release, PFS was also missed which cannot be attributed to second line ICIs. It will be interesting to see the data.
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@GABOUALFA Thanks Ghassan. Disappointing but not shocking. Landscape is becoming clearer for first line. “Line minus one is now line none.”
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Merck and Eisai Provide Update on Phase 3 LEAP-002 Trial Evaluating KEYTRUDA® (pembrolizumab) Plus LENVIMA® (lenvatinib) Versus LENVIMA Monotherapy in Patients With Unresectable Hepatocellular Carcinoma did not meet primary OS - businesswire.com/news/home/2022…
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@Amitmahipal79 @MayoCancerCare @UHhospitals @jorgegarcia @TedTeknosMD @doctorC369 Congrats Amit and Sakti!
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Daniel Ahn retweetledi
@the_danielahn @DrChowdharyMD @SprakerMDPhD @freddyeescorcia @chadinabhan @MayoCancerCare @rweichselbaum @jmmrad @subatomicdoc @MikeChuongMD @JoeHermanMD @olusolaodavies @KrishanJethwa @RadDocMReyngold “Given that olaparib is expensive and relatively toxic, and in the absence of a clear survival benefit, it may be difficult to justify its use”
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Concise and excellent editorial by @GIcancerDoc & @the_danielahn from @MayoCancerCare on the role of RT in non-metastatic pancreatic cancer.
Appears it should not be given unless part of a study. @rweichselbaum @freddyeescorcia @jmmrad @subatomicdoc
jamanetwork.com/journals/jamao…
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Daniel Ahn retweetledi
It is time we started treating radiation as experimental therapy in pancreatic cancer and found a way to prove its utility. I still use it where I believe it helps--such things as clearing margins and getting people time off systemic therapy, but would be nice to prove benefit
Tanios Bekaii-Saab, MD@GIcancerDoc
"In conclusion, there is very little evidence to support the use of radiotherapy in nonmetastatic #pancreaticcancer. Further exploratory studies may define a role in a select subgroup of patients with borderline resectable and locally advanced disease ...."
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@the_danielahn @GIcancerDoc I see.
Thank you very much Mr. Elon Musk for the timely unblocking.
Dallas, TX 🇺🇸 English
"In conclusion, there is very little evidence to support the use of radiotherapy in nonmetastatic #pancreaticcancer. Further exploratory studies may define a role in a select subgroup of patients with borderline resectable and locally advanced disease ...."
Daniel Ahn@the_danielahn
Our editorial on A021501. Do we really need radiation in PDAC? Continued Struggle for Defining a Role for Radiotherapy in Pancreas Cancer | Gastroenterology | JAMA Oncology | JAMA Network @MayoCancerCare @GIcancerDoc jamanetwork.com/journals/jamao…
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