Matthew Katz, MD 🇺🇸🟦

Behold: another infectious disease. Another curve breaking away from its historical baseline.

Very important study. Great read! Lymphopenia-sparing techniques may be meaningful here. Shortening the “number of insults” from 10 fractions to a 5-fraction regimen could help. Beyond fewer fractions, planning should intentionally spare the thoracic vertebral bodies, aorta, and heart to reduce exposure of marrow and the circulating blood pool. My unsolicited take: The median lung V5 on TREASURE was approximately 60%. With long craniocaudal central/N2 targets, lung V5 often becomes constraint-saturated around this level. Continuing to force V5 below 60% does not make the low-dose bath disappear. It may simply redirect dose through the heart, aorta, and thoracic vertebral bodies. RT planning is like stepping on a balloon: the dose has to go somewhere. In this setting, selectively relaxing lung V5 may meaningfully reduce integral exposure to more consequential immune structures. I routinely deliver 20-25 Gy/5 fx IMRT during maintenance single-agent immunotherapy in these scenarios, which has generally appeared well tolerated without unexpected safety signals. Random thoughts aside, congratulations to the authors! Really looking forward to NRG-LU007/RAPTOR and JCOG2002, although neither will directly answer whether a 5-fraction thoracic regimen reduces the depth or duration of radiation-induced lymphopenia. #OncTwitter #LCSM #RadOnc

@M_Torasawa @JCOG_official Striking that the control arm did better. Radiation-induced lymphopenia undermining IO effect makes biological sense. More isn't always better.

Important phase III data are still awaited before drawing definitive conclusions. 🇺🇸 RAPTOR (NRG-LU007) is evaluating consolidative radiation after first-line chemo-IO. 🇯🇵 @JCOG_official is also conducting JCOG2002 (yES-TRT), a randomized phase III trial testing the addition of TRT to atezo- or durva-based therapy in ES-SCLC, with approx. 240 pts planned for randomization. ascopubs.org/doi/10.1200/JC… 🔍 The optimal role and appropriate patient selection for consolidative TRT in the immunotherapy era remains an important open question.

@HSkinnerMDPhD @SerahChoiMDPhD @YvonneMowery @BhanuPr92961213 @UzomaMDPhD @free_radical28 @Haleyml1987 @UPMCHillmanCC @RadOncResidency #radonc #SRS #SBRT #CNS bit.ly/3SitHAd

Though radiotherapy as a treatment in stage IV NSCLC has traditionally been palliative, advancements in systemic therapies has renewed interest in aggressive primary-tumor control. This article from the IASLC's Advanced Radiation Technology Subcommittee explains further. 📄 Read the full article here: bit.ly/4bEmC3F #NSCLC #Radiotherapy #LungCancer #CancerTreatment #Oncology #CancerResearch

1. NRC is right to challenge the "ALARA" rule, which has been catastrophic for nuclear power. 2. Challenging ALARA is not enough. To unleash nuclear power in this country, the NRC needs to reject "LNT," the pseudoscientific radiation model on which ALARA is based. 🧵👇

"ASTRO highlights study on disappearing radiation oncology centers" The number of rad oncs that are produced in the U.S. has been inversely correlated with the number of #radonc centers in community/rural settings(!) auntminnie.com/clinical-news/…

It is so refreshing when @mcuban defends physicians on social media. The public have been fooled to think that doctors are the “bad guys”. It’s pathetic that people buy into the insurance industry manipulation.

Finally, after nearly three years, the UN admits what Israel was warning: Hamas is hijacking aid.

🚨 Erling Haaland refuses to throw Sørloth under the bus after Norway's defeat to England. 🇳🇴 🗣️ Erling Haaland: Alexander Sørloth is a great player and, more importantly, a very good friend of mine. Football is a game of decisions, and sometimes you make the right one, sometimes you don't. People watching from home have time to slow everything down and analyse every angle, but on the pitch you have a split second to make a decision. That's football. I'll never blame him for that moment because we've all been in those situations. Every player has made a decision they wish they could take back. I'm proud of what we've achieved as a team. Reaching the World Cup quarter-finals was something very few people believed we could do before the tournament started. We gave our country something to be proud of. We fought for every badge, every shirt and every supporter who believed in us. Losing to England wasn't because of one pass or one missed opportunity. We created chances throughout the game. We had moments where we could have scored, and they had moments where they punished us. That's football. Sometimes you win, sometimes you lose, but you never point fingers at one teammate. We win together, and we lose together. I'll always stand by Alexander, just as I know he'd stand by me. That's what being teammates is all about. We leave this tournament disappointed, but also proud. This is only the beginning for Norway, and we'll come back stronger.

The @EANOassociation Consensus Statement on Radiation Necrosis provides practical, actionable guidance for clinical practice. Randomized trials focused are now urgently needed. academic.oup.com/neuro-oncology… @EANOassociation @EORTC @ESTRO_RT @FondazioneNeuro

🚨 ARTO long-term update in oligometastatic mCRPC: SBRT to all mets + abi/ADT vs abi/ADT alone. @TheLancetOncol 👥 157 pts 🎯 ≤3 bone/nodal mets 💊 Abiraterone + ADT ± MDT/SBRT ⏱️ Median follow-up: 53 mo Results: ✅ OS: NR vs 50 mo ✅ HR 0.55, p=0.021 ✅ bPFS: 44 vs 18 mo ✅ rPFS: 44 vs 17 mo ✅ PC-specific survival improved ✅ No major toxicity signal from adding SBRT Big signal: MDT may be more than “delay next therapy” in oligometastatic CRPC. Caveat: phase 2, unplanned OS analysis, not originally powered for OS. Still: hard to ignore. 🔥 🔗shorturl.at/rEx5L @PCFnews @PCF_Science @urotoday @renalandurology @UrologyTimes #prostatecancer

Trying to understand if we are using the same terms globally @NikiSushentsev @Sophia_KamranMD @Prof_Nick_James @seanmmcbride @docpriyamvada @VedangMurthy @ndesai2005 @HimanshuNagarMD @rtdess @PCaParker @piet_ost @subatomicdoc @alison_tree @DrSpratticus @CZamboglou @a_dalpra

NEW: Mamdani claimed he did not know about one of his top officials planning to meet with an Iranian ambassador "until there was a press inquiry regarding it." He said they are "working on a new process" for meeting requests.

Alzheimer's disease drug development pipeline: 2026 "There are 158 drugs for the treatment of Alzheimer's disease in the 2026 drug development pipeline.... 73% of drugs in the pipeline are disease targeted therapies whose goal is to slow disease progression... A diverse array of AD pathophysiological processes is being addressed by drugs in trials." alz-journals.onlinelibrary.wiley.com/doi/10.1002/tr…

Yet another study shows a 24% reduced risk of dementia after the Shingles vaccine. This one in over 500,000 participants with a recent skilled nursing facility stay, adding to 4 huge natural experiments in 4 countries (US, Canada, Wales, and Australia) acpjournals.org/doi/10.7326/AN… @AnnalsofIM

POLL: Many Jewish adults feel unsafe in the United States, with a majority saying they feel less safe than they did before Hamas’s October 7, 2023, massacre in Israel. A significant share of Jewish adults, about 3 in 10, say they or someone in their household has experienced physical assault, verbal abuse, online harassment, or damaged property because of their Jewish background over the last year, according to the survey. About 6 in 10 Jewish adults say they feel “less safe” as a Jewish person in the US than they did before Hamas’s 2023 onslaught, including about 7 in 10 of those who are religiously Jewish. About 4 in 10 Jewish adults say they are “less likely” to wear, carry, or display things that might identify them as a Jewish person than they were before Hamas’s October 7 onslaught. About 1 in 10 Jewish adults say that in the past year, they or someone in their household has been physically assaulted. Read more on The Times of Israel.

🚨 Heads up: There's a large, multi-state outbreak of cyclosporiasis - an intestinal infection caused by the parasite Cyclospora cayetanensis. Michigan is hardest hit with 1,251 cases and 44 hospitalizations reported as of early July 2026. The source hasn’t been identified yet. 1/3

יש הבדל בין אופטימיות לתקווה. אופטימיות היא האמונה שהדברים ישתפרו. תקווה היא האמונה שאם נעבוד קשה מספיק ביחד, נוכל לשפר את הדברים. לא צריך אומץ כדי להיות אופטימיסט, אבל צריך אומץ, חוכמה, הבנה עמוקה של ההיסטוריה והאפשרויות, ויכולת לתקשר, כדי להיות נביא של תקווה...להיות סוכן של תקווה, לאהוב את האנשים שאתה מנהיג, ולהרחיב את אופקיהם כדי לאמץ את האנושות כולה - זהו סוג המנהיגות שנותן לאנשים את היכולת להתאושש ממשבר ולהמשיך הלאה. שבת שלום