Steve Chervitz Trutane ☮️

Required re-reading: Voltaire's "Questions sur les miracles" from 1765 👇 (image compliments of @WISTquotes - wist.info/voltaire/5957/)

Earliest known use of “π” to represent the ratio of circle's circumference to its diameter was by the Welsh mathematician William Jones in 1706… The ubiquity of π makes it one of the most widely known mathematical constants in & outside of science en.wikipedia.org/wiki/Pi #PiDay

@lpachter Might be playable on an ultrasonic theremin, but only bats & maybe dogs would be able to appreciate those high notes 🦇

@lpachter Wild, but what instrument could you play it on? Those notes are pushing 20 octaves above middle C. Also, it would be easier to read using a “8va“ nomenclature to avoid all those excessive ledger lines. Maybe “8va-19” to indicate 19 octaves up. 🎼 ultimatemusictheory.com/octave_sign/

I tried writing some sheet music with lilypond using Claude, and Claude seems to have inadvertently composed an original piece, i.e. I'm 100% sure this has never been composed before.

The NHS-Galleri trial results came out last Friday. 142,000 participants. 3 years. The most ambitious cancer screening trial ever run. The headlines: primary endpoint missed. That's a fact, and it matters. But I believe the headlines are missing the deeper story in these data – one that matters enormously to patients and to the future of cancer screening. Here's what the NHS-Galleri Test study showed: ✅ Stage IV cancer diagnoses – metastatic, typically incurable disease – declined substantially in the screened group, with >20% reductions across the 12 deadliest cancer types ✅ More cancers were found at Stage I & II, when treatment can be curative, in cancers that are typically diagnosed late (pancreatic, ovarian, liver, lung) ✅ 4x higher overall cancer detection rate when Galleri was added to standard screening (i.e., colonoscopy & mammography) ✅ Fewer cancers detected through emergency presentation – the worst possible way to learn you have cancer, and the most lethal and most costly ✅ No serious safety concerns. Test performance consistent with prior studies (with very high 99.5% specificity and very low false positive rate) So why did the 'primary endpoint' miss? See article for more detail & perspective on the study design, and the 'Stage Migration paradox' that masks enormous progress and clinical impact for patients.

@robertcoffin3 This study wasn’t testing mortality. It was just testing whether cancers were diagnosed earlier. The way to read it, without full data, is that cancers were not diagnosed as early as expected. (Obviously I do not want to give you medical advice.)

"Scott Joplin's story is deeply connected to Black History Month, not just because he was a black composer, but because he shaped American music in such a lasting way..." 🎼🙌🏼 #Ragtime #ScottJoplin #AmericanMusic #BlackHistoryMonth #BlackHistory

@CharlesSwanton On the need for better cancer testing: "As medical advances improve longevity, more pts than ever face the looming risk of cancer recurrence – and the anxieties & challenges that go with it,” —Yuri A. Fesko, CMO @QuestDX agetechworld.co.uk/insights/curre… via @AgeTechWorld #MRDtesting

Also see @CharlesSwanton's awesome 2023 tweetorial covering TRACERx lung cancer +other studies: x.com/CharlesSwanton… "incorporate #MRD into clinical decision making... ctDNA testing might help tumor boards make treatment decisions earlier" #ctDNA #cfDNA #NSCLC #LungCancer

Clinical evidence via $PSNL's collab w TRACERx consortium—TRAcking Cancer Evolution thru therapy Rx Study: Longitudinal ultrasensitive ctDNA monitoring for high-resolution lung cancer risk prediction cell.com/cell/fulltext/… (OA) #ctDNA #MRD #MRDtesting #CancerTesting #Oncology

The Fifth Dimension - Aquarius / Let the Sunshine In (1969) Masterpiece! 🌟

Proposed musical accompaniment: “Cloudscape” by Philip Glass @philipglass in “Koyaanisqatsi” youtu.be/t9byPyKh2rE?si… #clouds #weather #weatherPhotography #SatelliteImagery

The theremin, invented in 1920, is the only instrument played without touching it, using electromagnetic fields to create sound.

Health care costs are cannibalizing the economy — consumers can fight back. How to fix it 👉 x.com/jordanbruneau/… by @jordanbruneau US health expenditures: $5.3T = 18% of GDP… “more than the entire economies of every other country in the world except China” 🤯 #healthcare

📑 New npj Precision Oncology study shows how NeXT Personal® is transforming immunotherapy monitoring across advanced cancers! With only 10-40% of patients achieving durable benefit on immunotherapy, ultrasensitive ctDNA testing to monitor patient response to therapy is critical: 🎯 Molecular response detected 23 days post-treatment start. 🎯 Progression caught 5+ months before imaging. 🎯 33% of detections in ultrasensitive range (<100 PPM). 🎯 ctDNA clearance = 7x higher overall survival. Ultra-low level detection is changing the game .💪 📰 Full study: bit.ly/3ZeJMHl. #PrecisionOncology #ImmunoTherapy #IOMonitoring #CancerResearch #CancerDiagnostics #ImmunoOncology #ctDNA #MRD

Singularity has arrived? 🤖 No humans needed: New AI platform takes industry by storm: x.com/axios/status/2… via @axios 🤖 “AI agent… comparing notes about u w other agents on their private social network” #AI #Moltbook #Moltbots @openclaw #techSingularity #singularity

@PeterMallouk Not first time: In FY2024, US spent more on national debt interest payments ($882 bn) than on national defense ($874 bn). High debt service costs will crowd out other priorities, undermining ability to protect nation & support allies: bipartisanpolicy.org/explainer/why-… via @BPC_Bipartisan

For the first time ever, the U.S. is spending more on interest payments ($1.20T) than on national defense ($1.16T). The cost of past debt now exceeds the cost of protecting the nation. The bill for decades of borrowing has come due.

Bertrand Russell’s timeless message to future generations

🍸💥 😱 #cocktails #cocktail #mixDrinks #mixedDrinks #liquidNitrogen #LN2 #drinks

Comparing cooperative geometric puzzle solving in ants versus humans doi.org/10.1073/pnas.2… (OA) Tabea Dreyer et al. + @feinermo ✉️ “complex brains require extensive communication to cooperate efficiently” #CollectiveCognition #cooperation “Longhorn crazy ants” 🐜

The original silver alert was posted by @ai6yrham on Bluesky here: bsky.app/profile/ai6yr.…

I went to check up on last night’s Silver Alert issued by @CHPAlerts for 74-yo Jesus Aranda of Vallejo — but the alert post on X has been deleted… Found it on androididee.nl via Google, but the page there is now 404. Was he found? @VallejoPd #MissingPerson