Mark Valladares

@UltraSkool1 @SterlingCooley Great visuals, do you produce this yourself?

Microtubules are not merely structural scaffolds; they are sophisticated quantum optical devices. Theoretical modeling suggests that the electric dipole fields of ordered water molecules within the microtubule core couple with quantized electromagnetic radiation. This interaction triggers Dicke superradiance, where $10^4$ to $10^5$ dipoles emit light collectively and coherently. Through self-induced transparency, these optical pulses propagate through the hollow core without scattering or energy loss. The result is a long-range coherent quantum state extending across tens of microns, shielded from physiological thermal noise. This non-linear optical signaling enables high-speed computation at the biomolecular level. By functioning as interconnected quantum networks, microtubules provide the substrate for cognition and the emergence of consciousness. sciencedirect.com/science/articl…

Zhang Kai shows that MTs alone are “responsible” for the inception of cellular activity (dynein-dynactin complex forms spontaneously (adapter-independent) on MT). pubmed.ncbi.nlm.nih.gov/41708859/

@UltraSkool1 Nice graphic

Consciousness is not merely a product of synaptic firing; it originates within the quantum architecture of neuronal microtubules. Tubulin proteins contain hydrophobic pockets formed by aromatic rings, creating vibrant pi-electron resonance clouds. These structures facilitate quantum dipole oscillations and superradiant energy transfer across the microtubule lattice. Unlike classical systems, these biological networks leverage Fröhlich condensates to maintain quantum coherence at physiological temperatures (~37°C). Experimental data confirms that anesthetics selectively bind to these pi-cloud regions, suppressing coherence and effectively abolishing conscious states. Spectroscopic modeling now validates that these aromatic rings are the primary site for consciousness-regulating dynamics. This mechanism bridges the gap between quantum physics and cognitive neuroscience, defining the brain as a biological quantum computer. pmc.ncbi.nlm.nih.gov/articles/PMC92…

@micahgallen Fantastic mapping!

Neuropeptides act as diverse signaling molecules that regulate both basic bodily functions and complex cognitive processes within the human brain. doi.org/10.1038/s41593…

@MillerLabMIT Slouching towards criticality, lest it implicate a causal substrate.

I'm not so sure we "stumbled" on it. How anesthetics destabilize the brain: scientists stumble upon common mechanism biotechniques.com/biochemistry/h… #neuroscience

@FluxJEFF @SterlingCooley @StuartHameroff @QuantumTumbler Interesting, he blocked me too after I called him out on the limitations of topological models, what a Bozo!

@SterlingCooley @StuartHameroff @QuantumTumbler Demand mechanism. Then dismisses your idea publicly but privately takes your idea and blocks you. Pretty sure @StuartHameroff wins the debate.

The ‘overwhelming evidence’ you cite is from articles which show anesthetics do bind to membrane receptors but without measuring their simultaneous binding to microtubules. For example ketamine binds to NMDA receptors (causing hallucinations and dissociation) and also binding to microtubules to cause anesthesia. And the gas anesthetics bind only by quantum van der Wasls interactions. Meyer-Overton is the Rosetta Stone for consciousness. Anesthesia researchers have been trying to ignore it since the early 80s, wanting to be like regular pharmacologists. It hasn’t worked. The evidence points to anesthetic action on microtubules. academic.oup.com/nc/article/202… Let’s see evidence that anesthesia acts on membrane receptors without acting on microtubules. Finally, the Eger et al (2008) paper also rules out anesthetics acting on groups of membrane proteins pubmed.ncbi.nlm.nih.gov/18713892/ Anesthetics bind to myriads of molecules. The actual evidence points to anesthetic action (blocking consciousness) on microtubules.

@StuartHameroff Wonderful! But I think Scholes is at Princeton.

The Templeton World Charity Foundation (TWCF) attempted a lofty achievement, compare leading theories of consciousness in a kind of tournament. Two theories were to design a common experiment whose results would favor one or the other. Winner moves on. The idea, I was told at the outset, was to eliminate theories till there was a ‘champion’ (kinda like the March Madness college basketball tournament so many of us are now obsessed with). TWCF initially invited 5 theory groups, Four of them IIT, GNW, HOT and PC/RP. I lovingly refer to as cartoon neuron theories because they’re based on simple threshold logic devices at one low classical frequency, so not biological at all. The fifth theory was our Orch OR theory and we attempted an adversarial collaboration with IIT but couldn’t come to a common experiment. TWCF gave us funding to do experiments to falsify Orch OR ourselves. We predicted we would 1) show warm temperature functional quantum mechanisms in a microtubule, and 2) the effect would be inhibited by anesthesia. My colleagues feared I had promised too much. The experiment was done in a neutral lab (Greg Scholes at U Penn) and indeed showed quantum optical excitations persisting and propagating beyond classical limits, hence quantum. And they were inhibited by isoflurane and etomidate anesthetics. pubs.acs.org/doi/10.1021/ac… The cost was $100k TWCF gave $5 million to IIT and GNW for a massive study which was inconclusive and found fault with both theories, pmc.ncbi.nlm.nih.gov/articles/PMC12…

1/ Excited to share our new Nature paper: Functional hierarchy of the human neocortex across the lifespan We built a continuous normative reference for the brain’s major functional connectivity gradients from 16 days after birth to age 100. nature.com/articles/s4158…

@QuantumTumbler It’s simple, topology does not account for a path dependent mechanism implicated by the lag in induction and then emergence of conscious awareness for anesthesia at the same threshold.

@QuantumTumbler A genuine problem with a classical model such as Network Synchronization is that there is no physical substrate for the persistence of state space/memory beneath synaptic time frames; so anomalies like hysteresis (the lag in induction/emergence) remain paradoxical.

That paper doesn’t say anesthesia can’t be explained by membrane proteins it questioned whether any single target explains everything. Since then, we’ve got overwhelming evidence that anesthesia works through multiple classical mechanisms across known receptors and networks, with direct experimental proof. What you’re pointing to on the microtubule side is still modeling, lab analogs, and correlations not a demonstrated mechanism in living brains. There’s a big difference between “we don’t fully understand every detail yet” and “therefore it must be quantum microtubules.” Right now, one has causal evidence. The other doesn’t. That’s the line.

@QuantumTumbler Attractor dynamics in topological models account for transitions in a fixed state space which exhibit hysteresis phenomenologically but in conscious organisms, a path-dependent deformation of the state space implicates a substrate capable of retaining state dependent structure

@QuantumTumbler Yes, not about inference! Loss of consciousness at anesthetic level X, recovery at Y. But X ≠Y. “Basins” and “bifurcation delay” are descriptive not causal. Topology does not account persistence, if connectivity is disrupted, what holds the state space in place?

@StuartHameroff There is no paradox because the backwards time propagation happens with the temporal frame of the Planck scale. It’s a stunning elegant solution to conscious processing of the now that explains feed forward mechanisms.

There’s no causal paradox if the retroactivity doesn’t affect collapses that have already occurred. Without retroactivity you’re literally living in the past, and real time conscious control is impossible. frontiersin.org/journals/integ…

arxiv.org/pdf/1012.1337 Quantum Geometric Tensor supplies the intrinsic geometry of the projective Hilbert space

onlinelibrary.wiley.com/doi/full/10.10… RNA strands self-assemble into Tensegrity Triangles (pre-stressed internal space/projective Hilbert space).

@anirbanbandyo I see a disproportionate set of Mandelbrot fractals.

For a decade, I was obsessed with flower of life, garden of gardens and so many brilliant concepts derived as part of time crystal. The plot below makes me nostalgic, then came projective hyperspace and primes, the fantastic days of entertainment gone, primes never return....

@anirbanbandyo But consider that such reiteration misses an aspect in biological structures in which the helical foldings form a tensegrity structure (RNA/MT), which in turn form an internal space (projective hyperspace?). The AI transformation has its own set of boundaries.

Helix of a helix of a helix, I remember to do this by hand with basic programming during corona, and today, any novice can do this writing code in AI tools, academicians have no idea, how fast knowledge is transforming, dream of yesterday is a recent history, there is no present.

@anirbanbandyo Tensors

Tensors or PDE, who will come finally? None, the third baby of science is growing slowly in Gokul, "projective hyperspace". Transformers use tensors to train, PDE is good for training, finally, PH will replace them, why? Because, its error free hardware friendly, sees infinity.

@anirbanbandyo Also sheds light on how proprioception (which can be modeled as tensegrity) creates a state space in the interplay between tension and structural integrity.

I am surprised that Xenodo is publishing so many creative articles, always felt that unknown platforms will come up with unknown, unprofessional scientists to change the world, and its happening, this paper is a pleasure to read, this is where unorthodox thoughts will rule us.