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NEW RELEASE: Today we're releasing CortexMAE: a family of fMRI foundation models trained on 2.1K hours of open fMRI data. We're also releasing Brainmarks: an open benchmark suite for evaluating fMRI foundation models. Full paper is on arXiv (accepted to ICML 2026) A thread:

Reward magnitude determines reinforcement learning efficiency | Science science.org/doi/10.1126/sc…

Two papers in Nature present AI systems that can assist throughout multiple processes involved in scientific research. The systems are designed to assist researchers in accelerating scientific discovery, not to replace them. go.nature.com/4tFHspz go.nature.com/3RQzXyL

Accelerating scientific discovery with Co-Scientist | Nature nature.com/articles/s4158…

Sleep chart of biological ageing clocks in middle and late life | Nature nature.com/articles/s4158…

A study in Nature Communications tracks the induced anatomical and functional brain changes detected one hour and one month after healthy adults were given their first psychedelic experience, 25mg psilocybin. go.nature.com/4uCLYX0

Neural networks might speak English, but they think in shapes. Understanding their rich *neural geometry* is key to understanding how they work – and to debugging and controlling them with precision. Starting today, we’re releasing a series of posts on this research agenda. 🧵

A circuit-based framework for depression: Reshaping the pathological attractor: Neuron cell.com/neuron/fulltex…

Human #neuroimaging data across five major #psychedelics reveal a convergent #brain signature, highlighting a shared pattern of large-scale network #reorganization. These findings help understand how #psychedelic compounds reshape brain architecture. nature.com/articles/s4159…

Nature research paper: Functional hierarchy of the human neocortex across the lifespan go.nature.com/47jv4Dt

netneurotools: a trainee-oriented approach to network neuroscience | doi.org/10.1101/2025.0… Our lab’s internal toolkit for accomplishing everyday tasks in brain imaging ⤵️

💭Closing out Day 2 of #NYCPW2025 with @ulgenklc’s talk on Network Theory in Psychiatry and some hands-on project work! 🙌

Mind captioning: Evolving descriptive text of mental content from human brain activity | Science Advances science.org/doi/10.1126/sc…

📢Interested in applying computational methods to advance understanding of mental health? Join us at @IcahnMountSinai for the New York Computational Psychiatry Workshop (Nov 10-12)! Apply by Oct 13: form.jotform.com/252448781112153 More info: bit.ly/nycpw2025 Please share & RT!

Redox-driven mineral and organic associations in Jezero Crater, Mars | Nature nature.com/articles/s4158…

An information-theoretic foreshadowing of mathematicians’ sudden insights | PNAS pnas.org/doi/10.1073/pn…

Paper submitted: "Spatiotemporal asymmetries on brain energy landscape uncover system entrapment related to depression severity" #depression #mdd #rsfMRI #DTI #networkcontroltheory #attractordynamics researchsquare.com/article/rs-731…

🚨Our lab is hiring a postdoc! The Brain Networks and Cognition lab labs.icahn.mssm.edu/jacoblab/ Clinical neuroscience & cognitive neuroimaging to study effects of long COVID Good pay/benefits + subsidized housing in NYC! yael.jacob@mssm.edu @IcahnMountSinai @MountSinaiPsych

Scientists are workers nature.com/articles/s4225…