Vasudev Bailey, PhD

The combination of GLP-1 drugs (such as Ozempic) and healthy lifestyle factors was associated with less major adverse cardiovascular events in ~100,000 people with T2D @TheLancetEndo sciencedirect.com/science/articl…

Moderate consumption of caffeinated coffee or tea was linked to reduced #dementia risk and modest improvements in cognitive outcomes; no benefit was seen for decaffeinated coffee in an observational study of US adults. bit.ly/4amtd1c

Today in @NatureMedicine we report that AI can predict 130 diseases from 1 night of sleep🛌 We trained a foundation model (#SleepFM) on 585K hours of sleep recordings from 65K people—brain, heart, muscle & breathing signals combined. AI learns the language of sleep🧵

@reedhastings Disagree vehemently. It misses the unique needs of medicine and STEM fields where high-value contributions aren’t always tied to high compensation. It risks creating barriers for essential talent in those areas.

I've worked on H1-B politics for 30 years. Trump's $100k per year tax is a great solution. It will mean H1-B is used just for very high value jobs, which will mean no lottery needed, and more certainty for those jobs.

7/ Bacteria assist in tumor killing in a new paper out of @DanaFarber. Introduction of non-pathogenic, cytokine-expressing E. Coli into the gut of mice induced potent tumor immune responses & extended survival. nature.com/articles/s4158…

6/ Precision genome editing received two boosts: Prime editing efficiencies in primary cells are improved when increasing dNTP concentration, and when using a new synthesis method for pegRNAs. tinyurl.com/28trca4z tinyurl.com/4j7mydcx

TechBio Happenings! 🧵 1/ A full fly connectome 2/ A bacterial vaccine 3/ Schizophrenia drug approved 4/ RNAi drugs for obesity 5/ Rewiring the cancer transcriptome 6/ Improved Prime editing 7/ Bacteria boost tumor killing Research by @JuliaBauman2

I agree @ItaiYanai —well written! 👏

BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

@Kanthan2030 Definitely cool but not the first time we’ve seen this. @VertexPharma and Viacyte showed similar results years ago. Hopefully we can get something for commercialization from one of these groups soon

China just cured Type 1 diabetes with stem cells! Within 75 days, the patient had normal glucose level; and has maintained that for a year now. Groundbreaking medical accomplishment! And the surgery takes only half an hour!

7/ Via delivery of 3 transcription factors, tumor cells can be “reprogrammed” to dendritic cell-like antigen-presenting cells that provoke T cell activation. This strategy enabled 50% complete response in mice with xenograft tumors. tinyurl.com/dp39xrus

6/ @NSF has granted $22M to establish a “biofoundry” supporting study of microbes that thrive in extreme environments, with the aim of discovering new tools for biotechnology from nature. twitter.com/omalleylab/sta…

TechBio Happenings! 🧵 1/ Making tissue transparent 2/ Pairing immunotherapy & HSC transplant 3/ Designing disordered proteins 4/ mRNA monkeypox vaccine 5/ Simplified phage genome editing 6/ ExFAB Biofoundry 7/ Making tumors attract immune cells Research by @JuliaBauman2