Wade Buehler

@ifixhearts Fantastic. Can you explain it to my cardiologist. Maybe I can get off the statin that's ramping up IR and turning me diabetic.

I no longer accept the paradigm that high LDL cholesterol is the cause of heart disease

@Livingonahill @SamaHoole I prioritize protein and eat low carb veg and fermented food myself. Couldn't handle carnivore. I need diversity.

@SamaHoole I doubt I'll ever go full carnivore, but since I discovered your posts, I'm buying meat from the local farm, using butter, not seed oils, checking ingredients. Just being more aware of what I buy, eat and wear. Thanks!

Here is a thought experiment. You are dropped in a field in Britain. No shops. No roads. No supply chains from Peru or California or Thailand. Just the land, the rain, and whatever grows here. Your options: The cattle grazing the field. The sheep on the hillside. The eggs in the hedgerow. The fish in the river. The game in the wood. Or: you can wait until summer, cultivate a patch of ground, grow some vegetables and grain, hope the weather cooperates, hope the pests don't cooperate, and try to process enough stored carbohydrate to survive a British winter. One of these strategies has kept humans alive in this climate for forty thousand years. They did it without refrigeration, without supplements, without fortified oat milk, and without any apparatus except a fire and a knife. The other strategy failed sufficiently often that famine was a routine feature of British life until the nineteenth century. We are not in a field. We have the luxury of importing quinoa and pea protein and synthetic B12. That luxury is real and I'm not pretending otherwise. But when someone tells me that the food keeping those people alive for forty thousand years is a modern health crisis, I want them to explain which part of the timeline they think went wrong. Was it the Mesolithic? The Bronze Age? The Celts with their bog butter and their height advantage over the Roman legions? When exactly did beef become the problem? Point to the century. Take your time.

My experience was exactly that. Treated for T2D 30+ yrs. Lost 250 lbs, suffered every complication, switched to Keto, reversed T2 in 6 weeks, LDL went up, got a lecture, told him I'd stop eating all that real food like leafy greens, salmon, chicken and pork and go back to Fruit Loops, burgers and pizza to lower it. Currently seeking new doctor.

No one says anything when I eat the ultra-processed junk food on the left. But when I eat the healthy natural food on the right, that humans have consumed for millenia, people become concerned. What is your experience? h/t @SamaHoole

@SBakerMD The whole system is broken. I reversed t2d 3 yrs ago. Then Had a MI and CABG from 40 yrs hyperinsulinemia, put on statin, a1c up, diabetic again. Which is how it started to begin with. I asked for fasted insulin, she didn't even know that could be done.

Mainstream dietitians and doctors “Carnivore is bad for you, you’ll end up with scurvy and you’ll get sick” A million carnivore diets later, most got far healthier, none got scurvy “If they can’t even get this part right, what else are they wrong about?”

@BenBikmanPhD Here’s another helpful tip. Just tell the program not to use em-dashes.

One problem with AI writing is that I actually enjoy using em dashes. AI uses them so often that I've stopped, lest it be a false-positive of AI use.

@drterrysimpson Sometimes they are necessary, but some, especially lipophilic ones like simvastatin, atorvastatin, can cross into the brain more easily. They also cause cognitive issues, and they block HMG-CoA reductase early in the cholesterol pathway and can increase insulin resistance

Your brain makes its own cholesterol and is largely isolated from circulating LDL by the blood–brain barrier. Statins lower blood LDL—they don’t ‘drain’ the brain. If they did, we’d see dementia signals in trials. We don’t. This isn’t physiology—it’s a slogan

@AndrewCohill @joaniej0243 @PaulReynoldsPhD Hey Andrew, I think you mean LDL went up. You want HDL to rise. And you're right. Most doctors don’t understand any of it. I tell them I eat a diet of whole, unprocessed food and I cut back on rice, potatoes and bread. It seems easier for them.

I had my annual wellness check recently. My HDL went up slightly outside high normal, and my doctor immediately wanted to put me on statins! After some reading, I discovered that a keto diet can cause a modest rise in HDL. I had told him I was eating keto, but it is now obvious he does not keep up with some of this. Needless to say, I won’t go near statins.

Ischemic heart disease remains the world’s #1 killer, claiming over 9 million lives every year. We’ve blamed fat and cholesterol for decades, but the evidence points elsewhere. The real accelerator is glycation—excess sugars binding to arterial proteins—sparking chronic inflammation that stiffens vessels and builds deadly plaques. Control insulin resistance, and you protect your heart at the root. #InsulinResistance #Glycation #MetabolicHealth #HeartHealth

@RacecarengTom @BenBikmanPhD I lost 300 pounds and reversed T2D and can't help but wonder, if it isn’t one disease, creating many different symptoms, in different people.

@BenBikmanPhD Different for different people, just like metabolic disease creating different diseases in different people.

When it comes to understanding the progression of insulin resistance through the body, I think that fat cells are often the first tissue to become insulin resistant. Others embrace the idea that muscle or liver becomes insulin resistant first. The flaw in this thinking is evident in the normal glucose levels that persist for years with insulin resistance. Once the liver and muscle become insulin resistant, glucose levels won't remain normal for long--they're too important to glucose regulation. The fat cell, on the other hand, can be insulin resistant without disrupting glucose much due to its low glucose demand. Fat falls first.

@nicknorwitz Post MI AND CABG high-dose statin (rosuvastatin 40 mg), my HbA1c rose from ~5.6 → 6.3 with fasting glucose climbing and new post-meal spikes, no lifestyle changes. Lipids improved, but insulin resistance persisted. Not anti-statin— we need to manage the metabolic trade-off too.

Cardiology has become obsessed with the mantra “lower is better.” Lower LDL, lower ApoB, and you're going to be better off. This simple tagline misses the forest for a stupid little cholesterol shrub. It’s well known that intervening to lower LDL and ApoB doesn’t necessarily result in better overall outcomes for the whole person, even in circumstances where cardiovascular risk might be reduced. It's therefore incredibly sad when "certain cardiologist experts" (heavy quotes there) make false claims like: "people with a PCSK9 loss of function mutation have very low LDL-C and live 15-20 years longer than those who don't. And we have meds now that cause that effect." That nonsense I could forgive. What is far more troubling is that there's a general failure to challange problematic (and sometimes outright false) narratives like this provided they align with the status quo, even when the status quo has failed public health miserably. We need to broaden the aperture of the discussion because the "science is not settled." Below is an excerpt from this morning video on the lipid marker linked to longevity (not LDL or ApoB): youtu.be/SnwbtYm2RDE 🚨Then, of course, watch The Cholesterol Code movie on Amazon and leave a review! #CholesterolCodeMovie @realDaveFeldman

@OtherworldJamie @BenBikmanPhD I’m working on the other route — AI pointed out em and en dashes to me, and now I’m determined to use them every chance I get. Still figuring them out — clearly didn’t get enough into this post… yet. Problem solved.

@BenBikmanPhD I'm working on the other route. AI had brought em and en dashes to my attention and I shall be using them as often as possible now. Wish I could have figured out how to get a few into this post...

@TrimpeChristine @BenBikmanPhD I’m a writer and formally trained typesetter. I cant catch a break.

@BenBikmanPhD Same. It’s so frustrating because I loved a well-placed em dash as a writer!

@BenBikmanPhD I have the same problem, Ben. I am a writer, and trained typesetter. Em-dashes are the Swiss Army knife of grammar: stronger than a comma, looser than a colon, and mimic the way we talk. But, oh no, we can’t use them any more.

@DrSuneelDhand I use it a lot, to handle a complicated history. I’m not ready to trust it completely, but it does help facilitate conversations with my doctor.

I have talked to at least two people in the last couple of weeks, no medical background whatsoever, telling me how they are routinely having medical conversations with AI— really happy with the results, and telling me they think it’s way better than talking to their doctor. I really don’t think the medical professional understands what a complete gamechanger we are witnessing. A lot of arrogant physicians out there have no idea what’s coming!

@AndrewCohill @PaulReynoldsPhD You do, but your other markers have probably improved already. I was diabetic and it took me 6 weeks to be off of all those drugs, 9 months to get to a normal A1c, but my triglycerides went down and HDL went up very fast. Keep the faith and keep moving forward.

@wade_buehler @PaulReynoldsPhD I'm only three months on keto/low carb. I guess I need to be patient.

@AndrewCohill @PaulReynoldsPhD It depends where you are metabolically. Ive been low-carb for 3 years. My BP has improved a lot, and while my metabolic markers have improved significantly, I still have some insulin resistance and I take 4mg instead of the 8mg of coversill I took for years to keep my BP in check

@PaulReynoldsPhD How does glycation affect high blood pressure. I've been following a keto diet and an 18:6 fast for three months and have seen no change in blood pressure.

@followthemotive @paulsaladinomd 25 years ago nobody had ever heard of fasting insulin. And today, most doctors don't even know about it; if they do, they don't understand it, or know why it's important. They are interested in 2 markers. A1c and LDL.

@wade_buehler @paulsaladinomd If you are 300 lbs overweight you don’t need a fasting insulin test to know you are almost certainly insulin resistance and need to lose weight to improve cardiometabolic health.

My mother texted me the other day asking about her lipids. "What's your fasting insulin?" I asked. Her doctor has never ordered this, not once. She's going back to the lab to "complete" her bloodwork today. If your doctor doesn't order this lab, you need a new doctor.

@rorynotsorry There is no question that weight loss is incredibly hard; it doesn't get easier as you get older. The drugs also don't work the same in everyone, but if she's lost 40 pounds and has led to increased physical activity. I'd call it a good thing.

Just one more comment on the GLP1 crowd. My mother is severely obese. She is 76 years old. A few months ago she went on GLP1s and has lost 40lbs. She is more active now. Her blood work has improved. Is their argument that I should be calling up my mom and calling her lazy and a cheater?

@randymilanovic YIKES.

Auto renaming 1.3TB of images. (63,000 images).

@SapphyreBlues @RiseOfAlberta It won’t get passed and the redneck assbags will all whimper like babies.

@RiseOfAlberta I know zero about your laws. If y'all vote for Independence, what happens then? I really hope you get this passed.

Alberta will vote for Independence on Oct. 19th

@PressinAC @insatiablevine @ksorbs @XHealingChurchX Excuse me Austin. The grown ups are talking, here.

Canada just criminalized reading the Bible. Now quoting Scripture on marriage, sin, or God’s design for sexuality can be prosecuted as “wilful promotion of hatred.” This is how the West falls.