@JackHadfield14 Mast cells also have receptors that release Granzyme just like Killer T and NK cells. That kinda blew my mind.
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wigglethemouse
8.5K posts
wigglethemouse
@wigglethemouse
49ers and Swindon Town supporter. Engineer. #mecfs has got in the way of having a life
49ers Land Katılım Ocak 2009
140 Takip Edilen894 Takipçiler
Non exhaustive list of receptors on mast cells:
∙FcεRI (high-affinity IgE receptor)
∙FcγR (IgG receptors)
∙c-KIT (CD117)
∙MRGPRX2
∙TLR1
∙TLR2
∙TLR3
∙TLR4
∙TLR5
∙TLR6
∙TLR7
∙TLR8
∙TLR9
∙C3aR
∙C5aR
∙ST2 (IL-33 receptor)
∙IL-1R
∙NK1R (substance P receptor)
∙CRLR/RAMP1 (CGRP receptor)
∙PAR1
∙PAR2
∙PAR3
∙PAR4
∙S1PR1
∙S1PR2
∙CysLT1R
∙CysLT2R
∙H1R
∙H4R
∙A2A (adenosine receptor)
∙A2B (adenosine receptor)
∙A3 (adenosine receptor)
∙CB1
∙CB2
∙VPAC1
∙VPAC2
∙EP2
∙EP3
∙EP4
∙DP1
∙DP2 (CRTH2)
∙CCR1
∙CCR3
∙CCR5
∙CXCR1
∙CXCR2
∙CXCR4
∙LPA receptors
∙P2X7
∙P2Y
∙TRPV1
∙TRPV2
∙TRPA1
∙ERα (oestrogen receptor alpha)
Slovenščina
Further to this, most low-level mast cell treatments are semi-useless in excluding mast cell involvement. Mast cells have numerous downstream mediators and upstream triggers
Oversimplifying them to histamine and IgE is extremely narrow in scope and does not represent the reality
Jack | amatica health@JackHadfield14
Not reacting to food does not exclude mast cell involvement. Research shows mast cells may be implicated in Alzheimer’s, MS, migraines, neuropathy, ALS, pain, reflux, and blood pressure, despite these patients not reacting to food. Food hypersensitivity is just one presentation.
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@violinvet @Naomi_D_Harvey Yep. We got sunblock curtains and I reacted to the smell of them 😂
Six months airing in the garage before we hung them up.
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@wigglethemouse @Naomi_D_Harvey My body's general philosophy regarding things like sunblock is: if you can react to it, do it thoroughly.
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The sun ☀️ is finally in our garden in the mornings now so I’ve tried to sit in it for a bit to help my circadian rhythm etc. but it’s immediately causing the skin on my face to sting & feel like it’s burning. Other areas of my skin are fine though 🤷🏻♀️ it’s still sore hours later.
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@violinvet @Naomi_D_Harvey Thanks for the feedback both of you. It was good to be reminded that repeated exposure can desensitize the skin somewhat sometimes.
Sunblock clothes and good quality sensitive skin sunblock can help too. Unless you start reacting to the sunblock as well.
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@Naomi_D_Harvey @wigglethemouse For me, there was absolutely no change in anything that I could tell. It just happened, and went away the next year.
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@JackHadfield14 Sorry if I missed it what is the outer green line? Is it 3 standard deviations above high normal or something like that?
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Still can’t get over how nice these panels look and the depth.
Jack | amatica health@JackHadfield14
Vascular gene panel now available for all individuals with RNA results. Covers genes linked to blood vessel structure and function, including endothelial biology, vessel tone, angiogenesis, lymphatics, and barrier integrity. More panels coming soon.
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@violinvet @Naomi_D_Harvey I'm allergic to the sun since 2000. Did you have any thoughts on what might have caused it and why it disappeared E.g. perhaps a medication making you sun sensitive?
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@Naomi_D_Harvey I got randomly allergic to the sun on my arms a couple of years ago for just one summer. It was random, and quite vexing.
And I didn't want to be on an antihistamine every time I went outside so I just went around with a parasol like a Victorian lady.
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@Z3R0Gravitas @Naomi_D_Harvey @clarejdaly I don't get much light all year round but I do get seasonal changes. Leaves appearing on trees and leaves disappearing from trees are two very stark downturns for me. Second week March, second week October.
Mike Snyder had a very good seasonal study a few years ago.
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@Naomi_D_Harvey @clarejdaly I mean to say, are there many who feel *better* in summer but get no notable UVB exposure? Counter-evidence.
Windows tend to block basically all UVB. Less so NIR.
I'd look at if NIR lamps compliment UV exposure, too. I think it may prime the skin to protect against damage.
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Oooooohhhhh this is the missing information that helps explain winter worsening in immune mediated diseases like ME 💡
Dr Sam Soete@sam_soete
Your immune system has seasonal rhythms that track with photoperiod. Pro-inflammatory gene expression peaks in winter. Anti-inflammatory pathways dominate in summer (this is oversimplified of course). ↓ UVB in winter → ↓ vitamin D → ↑ Th1/Th17 skewing → ↑ autoimmune flare risk ↑ UVB in summer → ↑ vitamin D → ↑ Treg activity → ↑ immune tolerance Several human studies suggest Tregs tend to be higher in late spring/summer and lower in winter. But actually the pathways linking UVB to immunoregulation go way deeper than just vitamin D, and it is important to understand that so you don't get dunning krugered into thinking you can replace it entirely with a vitamin D supplement. This is why autoimmune conditions tend to flare in winter and improve in summer. Not random. Driven by photoperiod and vitamin D status.
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@Sally_writes ❤️❤️❤️. That marketing career is being put to good use. 😍
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Yes, there was a yellow brick road for my home cinema viewing of Wicked 2 🧙♀️
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@nwagoner Fred said it wasn't up to him, it was a business decision. 49ers insure their top wages. Could he need to meet an insurance demand before returning? Reinjury could be a significant cost for the insurer.
How do these policies work?
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RE: Fred Warner and a potential return to #49ers. This Sunday would mark 21 days until the Super Bowl. Opening his practice window at any point from then would give maximum time possible to evaluate if he's ready to go with no real down side.
(That's probably true now, too, given that it's close enough to the time left on the season as a whole running out relative to the window).
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wigglethemouse retweetledi
In pre-2020 ME cases, analysis of over 7000 proteins demonstrates that exertion disrupts T and B cell signaling, IL-17 pathways, and mitochondrial metabolism in comparison to healthy sedentary controls. Protein signatures correlate with symptom severity.
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@mecfsskeptic I would say for neurological/peripheral nerve effects sjogrens is a close match.
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Question: of all medical conditions and diseases*, which one's presentation do you think is most similar to ME/CFS?
* Excluding overlapping syndromes such as fibromyalgia, Long Covid, POTS, MCAS, hEDS, etc., which are equally poorly understood.
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@lifeanalytics @OpenMedF I thought that summary was fascinating. You don't normally write 3 papers for null results. Fingers crossed. And this work has been progressing for quite a number of years.
I'm looking forward to see how well the radioisotope labelling worked that was on previous web version.
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Based on the latest data, I am very hopeful for this work by the @OpenMedF related to nitrogen metabolism : ns1.omf.ngo/nitrogen-metab…
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wigglethemouse retweetledi
Severe and very severe ME/CFS patients are the sickest patients I’ve ever seen - even compared to septic transplant or end-stage cancer patients.
The unrelenting suffering and lack of research or definitive treatments puts severe ME/CFS on another level. Nothing compares...
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@Z3R0Gravitas I've enjoyed seeing them and knowing that you were able to get out and about. And yes the hedges were fun!
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@wigglethemouse A Mr Man of taste I see; you like hedges too. 🙂
Yeah, I see 17 too, thanks. But low 100s view count on a double sunny flowers post is a sign it's time to wrap these posts up soon, I think. For various reasons.
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Is Thursday dead internet day? I thought this colourful post would do better? Zero likes in the other place too. I say something silly?
The algo here is definitely decreasing my reach, tho. Showed this to no humans for first 15min, before tags. Then seemingly not to all those.😞
Richard Lewis@Z3R0Gravitas
1/2 #ThrowbackThursday, bonus pics from the corner house September shoot (linked below), for November cheer!: - Cyclamen (hederifolium Aiton), in the sun out front. - Different Dahlias, out back. - Nice colour but poor focus. #MEcfsEgress #BloomScrolling DailyNaturePics 204
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wigglethemouse retweetledi
Twelve years ago, Stanford Medicine geneticist Ron Davis shifted his focus to study severe chronic fatigue syndrome — the disease that has profoundly affected his son. Today, each new discovery, big or small, gives him hope for a path forward. stan.md/4nqAOBu
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@RorPreston @wecrunchme @ThereForME_UK History of latest HHV6 project funding
#description" target="_blank" rel="nofollow noopener">reporter.nih.gov/search/8_ybYR8…
Description of project.
brunel.ac.uk/research/Proje…
Without this grant there is no lab to process the Cure ME blood collection.
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@RorPreston @wecrunchme @ThereForME_UK FYI - you are missing the most significant team in terms of funding and length of research. Dr Jackie Cliff at Brunel. Dr Cliff runs the lab for the UK Cure ME group. I think Dr Nacuul's role is minor now he is in Canada.
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Earlier this year, @wecrunchme created a report on the UK ecosystem emerging around solving ME/CFS and long COVID, in collaboration with the wonderful @ThereForME_UK 🌱
The goal is to help sharpen our advocacy, and make it clear where support is needed & where gaps remain.
V happy to bring to this to X in a more social-ready version - please share and tag MPs etc! 🤝
#MECFS #LongCovid 🧵
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@mecfsskeptic Its worth remembering that this Stanford center has published recently on red blood cells deformability (with UC Davis), myelin basic protein breakdown, and a sizeable WGS study that concluded similar findings to DecodeME - before DecodeME.
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1) We watched the 2025 Stanford Symposium on ME/CFS and summarized many of the presentations.
While it's great to see so many talented people focusing on ME/CFS, we also noted that a lot of research is focused on hypotheses that are not yet supported by strong evidence.
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Annual Meeting with OMEGA, including an Oxford ME/CFS research update. November 13th, 17.15. Talks from Aleyna Lumsden, Beata Godlewska, Patrick Esser, Edie Guo & Inga Williams. Live streamed on TEAMS. eventbrite.co.uk/e/174811226383…. Full programme soon.
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@OxMEDiscovery Thanks for making the start time more accessible this year for those of us with large timezones differences.
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