Arendt Lab

biorxiv.org/content/10.110… Did you know that sponges can move? @FabianRuperti with @savitski_lab and @Prevedel_lab studied sponge movement and found an evolutionary ancient mechanism controlling cellular tension and defense which is also present in our vasculature! A thread 🧵:

A genome resource for the marine annelid Platynereis dumerilii biorxiv.org/content/10.110…

Happy to announce our new preprint on the ancestry of cell adhesion and self-recognition in animals! We used proteomics and structure-based searches to re-examine the Aggregation Factor from the classical sponge mode first studied by Henry Wilson in 1907! doi.org/10.1101/2024.0…

Sponges lack muscles & neurons. Yet, they move. How? EMBL Heidelberg Arendt Group @wormduty, @savitski_lab, @Prevedel_Lab & others, showed that sponge movement relies on an ancient relaxant-inflammatory response also found in vertebrate vascular systems. embl.org/news/science/a…

Our story about relaxing sponges is out today in @CurrentBiology! 🧽 For a concise summary, check out the thread below 👇 cell.com/current-biolog…

Many thanks to all the authors for this wonderful collaboration and additionally to: -@SANICHOLS_DU and @diz_lab for the great feedback -@althonos and @galicae for the support in python coding -@itn_ignite and @embl EIPP for funding @FabianRuperti

The ocean 🌊 in us: The maintenance of laminar flow is essential for both - sponge canal and vertebrate vascular system  Any deviation leads to the activation of this ancient conserved ‘relaxant-inflammatory’ response as a powerful defense reaction 🛡️.

biorxiv.org/content/10.110… Did you know that sponges can move? @FabianRuperti with @savitski_lab and @Prevedel_lab studied sponge movement and found an evolutionary ancient mechanism controlling cellular tension and defense which is also present in our vasculature! A thread 🧵: