Peter Wang

Excited to share the published version of our work @Nature! We revealed the mechanism + structural basis of microRNA degradation, and showed how ZSWIM8 defines a novel class of Cullin–RING E3 ligases + targets an asymmetric substrate as a dimer + uses RNAs in recognition. [1/2]

MicroRNAs control gene expression by modulating the output and stability of messenger RNAs. How are these crucial regulators kept in check? go.nature.com/4bvDc4T

This was an incredibly fulfilling collaborative effort between Bartel (Whitehead/MIT) and Schulman (Max Planck) labs, led by @jakobfarnung & Elena. Congrats to the team! [2/2] nature.com/articles/s4158…

Excited to share the published version of our work @Nature! We revealed the mechanism + structural basis of microRNA degradation, and showed how ZSWIM8 defines a novel class of Cullin–RING E3 ligases + targets an asymmetric substrate as a dimer + uses RNAs in recognition. [1/2]

The E3 ubiquitin ligase mechanism specifying target-directed microRNA degradation biorxiv.org/content/10.648… #biorxiv_biochem

Thrilled to share our work on transcription initiation and termination being spatially coordinated out today in Science! science.org/doi/10.1126/sc…

Excited to share our work with @DMSabatini & @JswLab. How do lysosomes change with age? We present a metabolic atlas of lysosomal aging, and reveal a lysosomal “aging clock” of metabolites linked to lysosomal storage disorders. Grateful to all co-authors! biorxiv.org/cgi/content/sh…

Target RNA recognition drives PIWI∗ complex assembly for transposon silencing dlvr.it/TMvgMj

A conserved PIWI silencing complex detects piRNA-target engagement dlvr.it/TMwC69

I am so incredibly excited to share our latest work, on the exploration of #RNA secondary structure ensembles and discovery of RNA regulatory structural switches in bacteria and human cells, out today in @NatureBiotech: nature.com/articles/s4158…. A short tread! (1/n)

@LVSoles Congrats!!

So excited that much of my thesis work is out today! This work was a huge group effort, grateful to everyone involved! 🎉🎉🎉

New preprint countdown! Mitochondria are cells within our cells. They need the same core activities - replication, transcription, translation. How do cells enable these diverse activities in both compartments? We uncover an unexpected strategy with ancient origins. Stay tuned!

Read the preprint at biorxiv.org/content/10.110… (2/2)

Check out the latest work led by @MatthewHarryHa1 in the Bartel lab! Matt solved a long-standing mystery about miRNA targeting, and drove the story to impressive mechanistic detail (1/2)

My PhD project from @daSpliceIsRight Lab/@MITBiology is out now in @NAR_Open! Thanks for great feedback & pleasant review process. Absolutely thrilled to be sharing this work w the world 🥰🤪 now onto the next chapter... 🐈🐈‍⬛😸😻academic.oup.com/nar/article/53…

Happy to announce that our paper on systematically discovering peptides to inhibit protein-protein interactions in living cells is out now @PNASNews: pnas.org/doi/10.1073/pn…. @MITBiology @ScienceMIT @HHMINews See quoted thread on the updated preprint for details:

Thrilled to announce the final version of our paper on computational discovery of protein fragments that can inhibit cellular protein interactions, led by Andrew Savinov (@bioSavinov), now published in @PNASNews. @MITBiology @ScienceMIT @HHMINews

cell.com/cell-reports/f… Congrats @MSherlockPhD!

Our review on small endogenous RNAs in animals is online. We thank @MartinjSimard, @SvobodaLab and the third, anonymous, reviewer for helping us improve our manuscript. bit.ly/3Ebk931

Today we're thrilled to announce our 2024 #HannaGrayFellows! Please join us in welcoming and celebrating these outstanding early career scientists! This cohort includes scientists working in research areas ranging from treatment-resistant cancers to sleep dysregulation to how animals evolved to live on land. Read more about HHMI’s Hanna Gray Fellows Program: hhmi.news/4gIsZU5

In this updated paper, we further described conformational changes required for catalysis, and a network of interactions near the active site that support slicing. Read more here: tinyurl.com/AGO2-slicing

More than five years ago, we charted our plans to unravel the biochemistry and biophysics of the AGO2 enzyme, and the eventual goal of solving its catalytic structure. It has been a great journey ever since, and we are excited to finally share these results.

Happy 2025! Excited to finally share our published slicing structure of human AGO2, the catalytic structure for RNAi by siRNAs and miRNAs. This was an amazing collab effort between @seyvos lab and Bartel lab with @AMohamed_98