Xinyu Feng

🧵1/n Excited to share our new preprint on CTCF dynamics. The small but powerful CTCF binds only ~20 bp, yet controls Mb-scale chromatin loops by directionally capturing a ~7x larger cohesin complex racing along DNA at 1-3 kb/s. How does CTCF do this?

A brief summary/perspective on my recently published PhD work: Nucleosomes constrain 1D DNA diffusion by eukaryotic transcription factors nature.com/articles/s4159… @taekjip

My PhD work is online! Huge thanks to my advisors Carl and TJ, and collaborators! @taekjip @maryamyamadi @FuYiben @Mejohnson81

"Native nucleosomes know where to go!” Our Condense-seq paper is now published in Nature! 📄 nature.com/articles/s4158… I’m deeply grateful to my PhD advisor @taekjip and our incredible collaborators @MuirLab , @binzmit , Erika Pearce, and Ben Garcia lab!!

The DelRosso Lab is starting @UCSF 1/2025 and is seeking applicants for a research postbac! We will be developing cutting edge high-throughput approaches to study the relationship between disordered protein interactions and transcription in human cells🔎 aprecruit.ucsf.edu/JPF05341

We are hiring a lab manager/research assistant. Hoping to interview and choose one over the next few weeks. Please apply through the Stanford posting careersearch.stanford.edu/jobs/life-scie… or email lbintu@stanford.edu with CV, transcript, career goals, and desired start date.

Proud to announce my latest preprint, the culmination of my dissertation research defended two weeks ago! As co-first author, I'm excited to share the "dynamic 1D search and processive nucleosome translocations by RSC and ISW2 chromatin remodelers". doi.org/10.1101/2023.0…

Check out this cool video made by @janetiwasa! The DNA and histone dynamics in the animation was based on our recently published paper with @MPoyton @taekjip and Carl Wu et al. science.org/doi/10.1126/sc…

COSB has a special issue on Biophysical Methods "Seeing is Believing". Free to read for three months. sciencedirect.com/journal/curren…

Want to know how long it takes SWR1 to remodel a #nucleosome? @xashleefeng and I used #smfret to watch SWR1 in action! Big-ups to everyone in Carl Wu’s and @taekjip’s labs for making this happen.

We posted two manuscripts on small RNA-based gene regulation in bacteria. Quantitative super-resolution imaging and stochastic modeling. Wonderful collaboration with Cari Vanderpool and Zan Luthey-Schulten labs. biorxiv.org/content/10.110… biorxiv.org/content/10.110…

Delighted to share my work @JohnsHopkins on ‘Very fast #CRISPR’ @ScienceMagazine ! Could not have done this without my fantastic advisors @taekjip @Binwulab, amazing colleagues @rogerszou, Shuaixin, Yuta, Xiaoguang, @sh_razavi and everyone contributed! science.sciencemag.org/content/368/64…

@vignesh_k757 @NogalesLab @berkeleyMCB @CUBIOCHEM1 @CUBoulder Congratulations Vignesh!

After 5+ years in the amazing @NogalesLab and at one of the best dept. @berkeleyMCB I will be joining another outstanding dept. @CUBIOCHEM1 @CUBoulder as junior faculty starting January 2021. Incredibly grateful to everyone who has taught me and worked with me. Still learning ...

Check out this new @elife paper from Carl Wu’s lab. They used live-cell single molecule imaging to show how RNA Pol II kicks H2A.Z out of promoters. doi.org/10.7554/eLife.…