Zach Abdo
1.9K posts

Zach Abdo
@z_pack_
Building tech solutions for 170+ nonprofits worldwide. & helping NGOs in Latin America raise millions for kids with cancer. Opinions my own.



Sitting on a beach is one of the more overrated life experiences


Of America's 40 CSAs with more than 1.5 million people, only 7 shrank in population from 2020 to 2025: - St. Louis (-6.3k people) - Detroit (-8.7k) - Chicago (-21.7k) - Cleveland (-26k) - Pittsburgh (-42.6k) - San Francisco-San Jose (-84.7k) - Los Angeles (-200.4k) The Rust Belt shrinking at least makes some sense in light of decades of economic malaise. California, though. Its presence on the list is a horror, brought on nigh solely by abysmal governance of one of the richest, most naturally advantaged places on Earth.

Randomized trial of an AI therapy chatbot on Mexican women found “improved mental health by 0.3 SD over 6 months with no evidence of an increase of severe cases; improved sleep, healthful behaviors, daily functioning & labor market outcomes” Big results for a cheap intervention.

Health advice: DO NOT let mitochondrial health influencers convince you to start smoking cigarettes

This is partly because many Americans still like to believe that journalists are a kind of priestly caste, with a higher calling; in Britain they have traditionally been seen as disfunctional larrikins; mischievous, shit-stirring chancers, somewhat beneath the salt. Depictions is US and UK films generally divide this way. I would be disappointed if British journos didn't nick the booze.

one of the best metafilter comments of all time gets more relevant every day

A team at Stanford and Arc Institute fed a language model a DNA sequence and asked it to write a new virus. It wrote hundreds of them. 16 worked. One of them used a DNA packaging protein that doesn't exist in any known organism on Earth.


Announcing my new thing: I'm launching a new public venture fund USVC is built by AngelList with @naval shaping our investment strategy in the technology companies building our future And unlike traditional venture funds, everyone can invest along with just $500:







New pod: SUDDENLY, EVERY NEWS STORY IS A FIGHT ABOUT ENERGY -> The Iran War is about energy flows -> The AI buildout is an energy project -> The future of populism—i.e., AI, electricity prices, data center moratoria—is an energy debate w/ @NatBullard Plus: - why politicians are wrong about the drivers of rising electricity prices - is the US auto industry doomed? - implications of the end of energy-demand stagnation - if the renewables vibes are so bad, why is solar still soaring? open.spotify.com/episode/2IBmF6…


Today's pod: WHY CHINA IS WINNING THE IRAN WAR Energy crises tend to have strange ripple effects. The 1970s oil crises contributed to (among many other things): - stagflation, the demise of the New Deal order in America, & the ensuing rise of Reagan Republicanism - the rise of the electronics revolution in Japan, as high energy costs punished heavy industry in the 1970s - even the rise and fall of the Soviet petro economy in the 1980s, which was a factor in the end of the end of the Cold War Nobody really talks about Reagan and Nintendo as consequences of an energy crisis. But, in a way, they were. So, today we ask: What could be the most important unintended consequences of the Iran War? I've learned a lot from American analysts, but I wanted to talk to somebody who's seeing the chessboard from the other side of the world. As @alexbhturnbull explains today, the U.S. relies on a military presence throughout the Pacific Islands to project its power in the east. But the war in Iran is demolishing the economies of the Pacific Islands, which may allow China to engage in diesel diplomacy—we bail you out on energy, you accept a larger military presence. Meanwhile, the war has revealed the vulnerability of seaborne fossil fuels, esp those that rely on the Strait of Hormuz. This could accelerate a shift toward renewables, where the largest global exporter of solar is ... again, China.

