Zenobiotic

@FrankieDHeyward I shouldn't be surprised, but who are we talking about here?

I'll be honest, the argument in favor of Early Career Investigator (ESI) preferences during the NIH grant review process parallels that for affirmative action, but it's beyond me why some would justifiably support the former while being ardently opposed to the latter.

@samjlord @mbeisen I was going to do this in my last paper, but thankfully a statistician stopped me. The concept of statistical independence is not clearly defined for biologists at all.

Any p-value smaller than 1/# of atoms in universe is not an actual result - it is a problem with the hypothesis or model

@JeffreyRMillman @JimJohnsonSci @mbeisen Σ*

@JimJohnsonSci @mbeisen All the asterisks in the universe :)

@oligopain 20trucks.com/trucktunes Honestly, these songs are pretty great, if your kid is into trucks (and what kid isn't).

@antonioregalado per month.

@antonioregalado My guesses: Series B: 1.6 mil Series A: 800k Seed: 75k

Anyone know the quarterly "burn" rate of pre-commercial biotech, on the average? How much does it usually cost to be a development stage biotech?

@TMGFlorida Don't think you know what a buzzword is, if you think "racist" and "fascist" are examples of one.

No matter how many times incoherent leftists try to say otherwise, Ron DeSantis is not a racist, fascist, homophobe, or whatever other pejorative buzzword they come up with.

@AlekseyVBelikov @mkaeberlein What's behind that age-acceleration is probably the immune surveillance of cancer falling apart, rather than, say, the rate of oncogenic mutations really taking off. But the effect is the same (slowing aging=fewer cancers).

@AlekseyVBelikov @mkaeberlein you sure?

The fights worth fighting are always difficult. In this case, we don't need to "win" to have an enormous impact on health and quality of life. A small attenuation of biological aging dwarfs the benefit of curing a single age-related disease like cancer.

@Atlassian2020 @mkaeberlein Potentially. But more likely, at least in the near term, you'd be compressing the window of morbidity (chronic disease) and having more people die of things currently defined as "sudden unexpected death", which tend to be various types of ruptures in the circulatory system.

@mkaeberlein Would it not effectively just create an intermezzo of benefits? One or two decades later people will still succumb to illnesses. We will try to treat those and burn money on them as we do now. Just a bit later in life.

@BrundoCoban @mkaeberlein Tell that to a bridge. The root cause of aging is the passage of time. But the damage caused by the process isn't irreparable.

@mkaeberlein Difficult fight since the root cause of aging is life.

In 2020, chronic (age-related) disease afflicted 50% of the population, and consumed >85% of health care costs in the US. That number is growing. When does the system break down completely? 90%? 95%? We need to start treating the root cause of these diseases, before that happens

@mbeisen Because neutral good is better, if all you care about is doing good. Chaotic good constrains the options you have for doing good, and needlessly puts you at odds with social orders.

why does anyone ever choose an alignment other than chaotic good?

@JoePostingg Also the generalizing of "mental health problems" to be just "any situation I feel unprepared to handle".

Feels like there's a trend where people use woke language to excuse pathological \ antisocial behavior.

@statesdj @OmicsOmicsBlog @antonioregalado Except for men under 40, apparently. Although it's such as small delta, you could really only detect it with the millions and millions of vaccinated patient records they have access to. So I'm not sure what they wanted public health officials to do.

@OmicsOmicsBlog @antonioregalado Also, worth noting that post infection, myocarditis is far more common than post vaccination myocarditis

@kevinnbass @mgpolitis Pay closer attention to the numbers in that study. The only reason they can suss out any interaction at all is because they had literally tens of millions of patients ( of which 2000 contracted myocarditis). There is no way to detect that low level of risk in trial.

@jasongesser @StephenKing That just means it's not a first amendment issue. It's still wildly hypocritical, capricious and arbitrary.

@StephenKing I thought it was a private company, they can do as they please, right ?

@100CIA_Medica @OdedRechavi I think the point is that it is a lot more work, and possibly a predatory arrangement, that the postdoc might have stumbled into unknowingly.

@OdedRechavi Nobody has to consult a superior on independent work that you are invited to do, unless the line of investigation is 100% not yours. If you are gaining experience and are meant to develope your own knowledge and thinking, why'd you ask for permission to put your brain to work?

PI when the post doc accepts a book chapter invitation without consulting with her first twitter.com/short_tymer/st…

@vectorgen @mbeisen It's kind of ridiculous that universities *don't* pay their own employees in the first place. Grants should be for regents and equipment. Full salaries shouldn't be routinely paid off non-training grant mechanisms.

I can't even with the people whose response to UC postdocs earning a living wage is to complain that they can't afford them anymore. That our field is dependent on exploitative labor practices is not their problem.

@mbeisen People have been pointing out this inevitable issue for 30 f-ing years and now they have the gall to act like its a suprise.