Zhen

161 posts

Zhen

Zhen

@zhenliuchem

Research group leader in the field of Biocatalysis

Beijing Katılım Ocak 2019
119 Takip Edilen296 Takipçiler
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Zhen
Zhen@zhenliuchem·
We are excited to share our recent work on a biocatalytic atroposelective platform enabled by engineered desaturases: nature.com/articles/s4416… MD-guided directed evolution played a key role in this effort. Congratulations to the whole team—more to come soon!
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Honglue Shi
Honglue Shi@honglue1·
🎉 Honored to be named one of the 2025 Rising Stars in Engineering in Health by @ColumbiaBME @JHUBME @CornellBME @BostonU_BME ! Excited to join an incredible group of scholars pushing the boundaries at the interface of engineering and health. Looking forward to the symposium in October!
Columbia BME@ColumbiaBME

We are thrilled to announce our 20 Rising Stars recipients who will be joining us for the 6th annual workshop this October. Learn more about our stars here👉 bit.ly/46sZvWF

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Zhen
Zhen@zhenliuchem·
We are excited to share our recent work on a biocatalytic atroposelective platform enabled by engineered desaturases: nature.com/articles/s4416… MD-guided directed evolution played a key role in this effort. Congratulations to the whole team—more to come soon!
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Zhen
Zhen@zhenliuchem·
We would be glad to engage in further discussion if the reviewer has remaining questions.
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Zhen
Zhen@zhenliuchem·
Taken together–the above-mentioned points, along with the observed kinetic differences in mutagenesis experiments, the ability to undergo directed evolution, and inhibition by phenol additives–provide strong evidence that the reaction is enzyme-catalyzed.
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Zhen
Zhen@zhenliuchem·
One reviewer of our aniline paper suggested that the reaction is likely not enzymatic due to the addition of SDS, which is known to denature proteins at certain concentrations. We provide the following reasons to support that it is enzyme-catalyzed:
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The Nobel Prize
The Nobel Prize@NobelPrize·
“I have four brothers and I’ve jumped into all sorts of things during my life. Learning new things has always been fun for me.” 2018 chemistry laureate @francesarnold received the #NobelPrize for her work using evolution to make better enzymes. Today she celebrates her birthday!
The Nobel Prize tweet media
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Christine Le
Christine Le@christine_m_le·
It’s official: I’m thrilled to share that I’ve been granted tenure and promoted to Associate Professor! Grateful for the support of my mentors, collaborators, students, and colleagues who’ve helped me reach this milestone! #tenured
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Zhen
Zhen@zhenliuchem·
Our team has recently published two research papers on Angewandte Chemie. Congrats to my students, Shuangyu Dai and Xiang Zhao, as well as our esteemed collaborators, Prof. Yunfang Yang and Dr. Xiahe Chen. The links are given below. Check these out if you are interested!
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Zhen
Zhen@zhenliuchem·
In our second paper, we demonstrate that chiral silanols containing Si-stereogenic centers can be prepared enzymatically with high efficiency and enantioselectivity. These structures were previously believed to be labile under aqueous conditions. onlinelibrary.wiley.com/doi/epdf/10.10…
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Chao Li Lab
Chao Li Lab@LabChao·
Thrilled to share our progress on the synthesis of highly oxidized DMOA-derived meroterpenoids—now out in JACS:pubs.acs.org/doi/10.1021/ja…! The unexpected reaction we stumbled upon in the final step turned out to be especially fascinating.
Total Synthesis@TotalSynthesis

#TotalSynthesis of DMOA-Derived Meroterpenoids: Achieving Selectivity in the Synthesis of (+)-Berkeleyacetal D and (+)-Peniciacetal I by Jianpeng Zhang, Xiaotong Luo, Jingfu Zhang, and Chao Li @LabChao in @J_A_C_S pubs.acs.org/doi/10.1021/ja…

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Nature Synthesis
Nature Synthesis@NatureSynthesis·
Now online: An Editorial highlighting some of the excellent covers featured in Nature Synthesis in 2024 as well as the research they represent. Thanks to our authors for submitting such great covers! nature.com/articles/s4416…
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Keşfet

@honglue1 @ColumbiaBME @JHUBME @CornellBME @BostonU_BME @barrybunin @francesarnold @christine_m_le