Amjad Askary

Spatial MOtif REcognition (SMORE) is now peer-reviewed and out at @GenomeBiology Updates include analysis of sequencing-based spatial transcriptomics (Slide-Seq) and a whole brain dataset with ~4 million cells, showing versatility and scalability of SMORE. genomebiology.biomedcentral.com/articles/10.11…

1/14 On behalf of the amazing team in @JswLab, we’re excited to share PEtracer (biorxiv.org/content/10.110…) a prime editing-based evolving lineage recorder compatible with both scRNA-seq and high-resolution imaging readouts in intact tissue. By applying PEtracer in a syngeneic mouse model of lung metastasis, we dissect how cell-intrinsic and environmental factors coordinately shape tumor evolution in vivo.

@arjunrajlab @adamlmaclean Kai Hoa from Amjad Askary's lab @AskaryLab on recording signaling histories in single cells via INSCRIBE Check out their bioRxiv: biorxiv.org/content/10.110… #SysBioSC2025

@ZernickaGoetz Congrats Magda!

I am excited to share that I have been recognized as a 2025 ISSCR Public Service Award Honoree! Read more about the award and my fellow honorees. invt.io/1txbkd4572u

@ahmetfcoskun @naturemethods @rita_strack Congrats Ahmet! This is exciting

Spatial proteomics is here, but spatial functional proteomics? Here is our Nature BME paper on spatial protein interactomics (nature.com/articles/s4155…) illuminating how 47 proteins co-localize/ interact within 20 nm and their function in tissues. @naturemethods @rita_strack

@SynBioGaoLab Amazing! Congrats Xiaojing.

So we beat on. Gene/cell therapies often use proteins that could be recognized/rejected as non-self by our immune system. We combine algorithms to build proteins that are therapeutically relevant and can masquerade as our own parts doi.org/10.1101/2025.0…

Nice article in Scientific American about our work on outer ear evolution and a complimentary study from the lab of Maksim Plikus on role of unique lipids in mammalian ear cartilage. @MathiThiru95 @USCStemCell @KECKSchool_USC scientificamerican.com/article/our-ea…

How does one (signaling) arm know what the other is doing in the cell? Through a network of bHLH transcription factors obviously! Our work showing how neural stem cells integrate signals to coordinate a fate response is now out: cell.com/cell-reports/f…

@SynBioGaoLab Congrats! This is amazing.

It's published! rdcu.be/d6kVt

A month ago we @vevo_ai announced that we have generated the largest single-cell perturbation atlas in history, Tahoe-100M. Today, we announce that we will fully open-source Tahoe-100M in Feb, as part of a collaboration with @NVIDIAHealth to train cell state models.

Special congratulations to @SamadiZain who developed a simple idea into a powerful algorithm.

Spatial MOtif REcognition (SMORE) is now peer-reviewed and out at @GenomeBiology Updates include analysis of sequencing-based spatial transcriptomics (Slide-Seq) and a whole brain dataset with ~4 million cells, showing versatility and scalability of SMORE. genomebiology.biomedcentral.com/articles/10.11…

A dream come true: in 2004 I started thinking about counting microstates to predict gene expression with @JKondev Rob Phillips @HernanGGarcia. 20 years later we can measure them: nature.com/articles/s4158… Thank you @WJGreenleaf @bgrdoughty @MichaelaThinks Julia and all co-authors!

New Publication Alert! our perspective of "Aging on a chip" and "Spatial Omics" in aging single cells. Decoding senescence of aging single cells at the nexus of biomaterials, microfluidics, and spatial omics npj Aging10, 57 (2024) Link: lnkd.in/ef7-ad7Q @CoulterBME

Check out our new review of molecular recording, exploring cutting-edge technologies and their transformative potential for biology. A collaborative effort across multiple labs—proud to have been part of this amazing team! 🌟

Incredibly excited that our paper linking single molecule states of TF binding to gene expression using quantitative thermodynamic models is out in Nature today. An amazing collaboration with the Bintu Lab. Congrats to Ben, Michaela, and Julia! nature.com/articles/s4158…

Our work describing molecular recording of sequential information by directing a chain of insertions with prime editor in mammalian cells is now published in @nchembio here - nature.com/articles/s4158…. Congratulations to Theresa Loveless, @CourtneyCarls_n, and the whole team!

Check out this amazing resource! High quality illustrations for free! bioart.niaid.nih.gov HT @LuciaScience