GloerichLab

Paper alert! β-catenin forms condensates that help build cell–cell adhesions - showing its role goes beyond simply linking E-cadherin to α-cat/actin. Great collaboration with the @Jschuije lab. Congrats to 1st authors @JooskeMonster & @ManzatoCaterina! nature.com/articles/s4146…

Many thanks to all collaborators (including @cperezgonzalez, @DMVlab, @vanRheenen_Lab, @Snippertlab) and the Dutch Cancer Foundation @kwf_nl for making this work possible!

In future work we hope to unravel how TRPV4 and integrins cooperate to control YAP signaling in CRC cells, and how mechanical forces intersect with other cues controlling CRC cell plasticity

Excited to share our new paper on mechanical forces regulating stem cell plasticity in colorectal cancer, involving force transduction via mechanosensitive calcium channels! cell.com/cell-reports/f…

@godinho_susana @_LisaDonker @wellcometrust Awesome!! Congrats Lisa!! 🍾

Many congratulations to @_LisaDonker in our lab for being awarded a 4-year Welcome Trust postdoc fellowship 🤩! I could not be happier for her ! So well deserved ! 🙏 @wellcometrust

The 2023 Cell Contact and Adhesion Gordon Research Conference (GRC) is coming up next June. This has been the premier meeting at the intersection of cell adhesion, mechanobiology, cell signaling, and their relevance to development and disease.

Good times with our friends @Huveneers_Lab

Gloerich/Huveneers labs retreat Having fun and discussing new epithelial and endothelial mechano-science!

Are you curious? Do you want to explore the unknown? Do you want to delve into our origins? Are you an extremophile-phile? Do you want to work in the fabulous LMB? Do you BioRXIV? Do you like scones & ride a bike? If your answers to some of these are yes, come join us @lab_baum

@Jor_Ferreir @CellReports @_LisaDonker @UMCU_CMM @XavierTrepat Thanks and yes, let's definitely catch up soon! Great to see our papers coming out the very same week!

@GloerichLab @CellReports @_LisaDonker @UMCU_CMM @XavierTrepat Congrats! Great to see this coming out. We should talk one of these days.

Our paper on a mechanical G2 checkpoint is out now @CellReports, in which we describe how epithelial cells sense when to divide cell.com/cell-reports/f… Great work from @_LisaDonker and everyone that contributed from our lab @umcu_cmm and @XavierTrepat and Borghi labs!

@margariddantas @JCellBiol Great to see this out! Big congrats!!

Couldn’t be happier with my PhD work being publish at @JCellBiol 🤩 Perseverance and hard-work will always pay off. Don’t miss it if you’re interested on how cyclinB1 can be mechanoregulated during prophase.

This mechanical checkpoint establishes a pool G2-halted cells in dense epithelia, which are readily triggered to divide when intercellular forces increase, for instance upon wounding - and thus coordinates cell divisions with cell loss

These cell density-dependent forces are transduced to the cell cycle by mechanosensitive E-cadherin adhesions via regulation of Wee1 and downstream Cdk1, thereby controlling G2 length and timing of mitotic entry