@churchill_dan @MarcusMilione Did it this morning. Great route and recommendation thanks guys! Fun way to explore the city
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@MarcusMilione @churchill_dan staying at the Bowery for a wedding next weekend. Never run in New York before and have to hit 20 miles. Where should I go?!
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@ChrisMasterjohn Biologic will also require a biologic license and the 351 pathway through the FDA. Which will make it harder for anyone else to do the same thing
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What’s funny about this is a “peptide” has an actual scientific definition whereas a “biologic” is a pseudoscientific term made up by pharma and regulators.
Mansi@mansizzzzle
Just spoke to an HHS insider & man, Eli Lilly is going nuts with the peptide wars First of all, as we speak they are pushing the FDA to reclassify the glp-1s as biologics instead of peptides so that: 1. Compounding pharmacies can’t touch them, as they’re not allowed to dispense biologics. Only large manufacturers contracted by big pharma can produce biologics 2. They can extend the patents by 10-15 years min The FDA classifies anything under 40 amino acids a peptide, over 40 a biologic & they’re pushing extremely hard on Retatrutide Retatrutide sits at 39 amino acids, technically a peptide. But the argument they’re pushing is that certain side chains should be counted as amino acids, pushing it over the peptide threshold This strategy has precedent since pharma already used it to push fertility compounds like HCG, FSH & HMG into the biologic classification, removing them from the compounding pathway Patents expire, but the classification system doesn't
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Literally the most common thing I see in SIBO besides low stomach acid,
Either the bile impairment led to the overgrowth or the bacteria themselves are leading to the bile being broken down.
Either way ensuring properly conjugated bile is a bigger lever than any antimicrobial.
Dr Sam Soete@sam_soete
Damn impaired bile function is such a big deal for so many people that struggle with gut issues.
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What my boyfriends will be wearing in their next ultra. Love what they’re doing at Satisfy. Definitely more men’s options than women’s, but this is a vibe. It’s rockstar rather than nerd. And runners are just a bunch of nerds. (As a runner I am allowed to say this.)
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GUYS I JUST RAN INTO KENDALL AT SUNLIFE AND LOWKEY WAS THE BEST MOMENT OF MY LIFE. GO ONE MORE!!!!! What a gem. @BPN_Supplements
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@MedDevTX @BPN_Supplements Tbf his coach Sam carried him up the stairs
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5.55 miles at 9:41 with a 125 HR
In Nov I did 12:38 at 135.
Even a month ago I was happy with 10:20 at 135.
I’ve taken minutes off my time and added years to my life.
I am totally different on a physiological level than when I started #ProjectUnreasonable.
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@frl713 @No_Divots @halsuttongolf There are cabins on the property. It’s an awesome track and a true golf club
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@No_Divots @halsuttongolf Cool piece of land and Interesting annual membership program, but hard to use given the location and lack of onsite lodging
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Darmor Club, about 1 hr west of Houston is a fantastic collection of template holes with great variety; short, long, dogleg right, left par 4’s and same thing with the par 3’s. Got to meet architect, @halsuttongolf after my round and talk about the course. Truly a special place!
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The Masters’ merchandising / design team truly missed the mark this year. I’m not entirely sure who their target audience is for these designs, but it’s likely not BV or the ultra wealthy.
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@MarcusMilione @churchill_dan Thanks Marcus that sounds great. Appreciate the response!
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@MedDevTX @churchill_dan over to the west side highway.
north to 59th street.
take a right and follow it to columbus circle
into central park
Loop the park (6 mile loop). can finish that way or run back down
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@Hybridathlete My wife makes fun of me cause that’s my favorite meal but it never gets old
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I promise the sunburn looks worse than it is lol it’s from yesterday and I promise I’ve been burnt worse
Taylor Mathis@TMathSports
Walking Bets with Polymarket in Antigua!!! 🌊☀️ Final 4! Arizona vs Michigan Michigan ML Who do you pick?! Use my code TAYLOR20 for $20 on the Polymarket app
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We don't often talk about the psychological harm of mass incarceration, but we should.
The Net Daily@TheNetDaily
Bro dreamed he was free… then woke up back inside prison
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@max_stoneking @GregLehman @ORION_coaching Dealing with some piriformis issues cause of this. Seems to lock up my leg if I go past 8-10 miles.
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“My glutes don’t fire when I run.”
1. They do or else you’d be nose down in the grass
2. What you’re describing is likely a coordination issue…brought on by fatigue
Better training helps that. Look there first.
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So I want to comment a bit on what weight-independent glp1 effects actually means.
I think statements like this get interpreted as “it doesn’t really matter if you lose weight or not, you just have to hit the glp1 receptor.”
That’s not really accurate. There is basically no one in these trials that doesn’t lose some amount of weight. To truly test the degree to which the effects would be totally weight independent, you would have to force feed individuals to maintain weight neutrality. That never happens.
What it is saying is that the amount of weight someone loses doesn’t predict the amount of benefit seen in these endpoints like joint pain or psoriatic arthritis symptoms. I.e. someone who loses 20% of their body weight isn’t necessarily going to do better than someone losing 10%.
However, they all enter a caloric deficit, and it goes under appreciated how impactful going from a state of constant energy excess to constant negative energy status is on nearly every cell type and organ system.
The response of an individual to entering a net negative energy balance state is really what’s being addressed here, and it’s not really “weight independent” because weight loss is a de facto pre-requisite.
Eric Topol@EricTopol
The list of conditions for which GLP-1 drugs provide benefit independent of weight loss keeps growing. Add psoriatic arthritis #AAD26 @AADskin
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