Mark Nelson

@NaOHBartfield If it’s like the Science I run into it’s probably both- Chlorine? Class? Anyone?

@NaOHBartfield A good spectroscopist could tell us what elements and perhaps molecules are involved- class? Anyone?

Yayy :3

@drugmonkeyblog If you create a drug in a University setting, they take 60% of the royalty stream don’t forget regardless if NIH funded. Can you say Administrative Bloat?

I suspect people in science are also about to find out about the F&A costs of research being amortized across the recipient institution vs being charged to directs. The classic example is “but I have one office so IDC should be reduced for my second and third grants!”.

@MiraCB007 @MitoPsychoBio Un pasteurized milk or follow the procedure in us patent 8431174 and pull the globs out of whey using diafiltration or chitosan- or just drink whey

@MitoPsychoBio Young humans need fat comparable to mothers milk. All baby yogurts and fromage frais are (should be) whole milk. I wish there are options with non-homogenized milk, in order to deliver milk fat globule phospholipids, to feed developing gut microbiome.

Feeding mitochondrial fatty acid oxidation helps babies sleep? Any research on this?

@brunogomezgil @baym Did they not find resistant E. coli in 250k year old ice cores? I referenced this paper- be back - I was a resistance fighter last wave- we just made new antibiotics

@baym Antibiotics and antibiotic resistance is a chemical warfare between microorganisms and has been going on for millions of years in the environment. I guess this study is only with clinical isolates.

This paper has been a long time coming: We looked at the genomes of historical bacterial samples over a century to look for trends of antibiotic resistance genes, finding multiple instances of them in infections before the age of antibiotics...

@That_Chemist Is compound 10 reactive with nucleophiles? Nice!

You often see BBr3 used to cleave aryl methyl ethers, but you may not know that it can also react with C-F bonds as well!

@drtimothyli Nuzyra as the best Tetracycline for Gram - should have been in the panel. And it’s orally active not like Tygacil.

One of the biggest reasons why we need antibiotic stewardship is to avoid creating scary monsters like this⬇️ How are you going to treat this?

@MitoPsychoBio During OxPhos calcium goes haywire. The tetracyclines induce mitohormesis AND stop calcium induced dysfunction. This family regulates and controls inflammation while no other family compares.

How much energy do cells and organisms with impaired mitochondrial OxPhos waste in mounting (futile) stress responses? Could hypermetabolism - rather than ATP deficiency - cause symptoms and disability in mitochondrial diseases? nature.com/articles/s4225…

@chemiolis It's used all the time in inorganic chem and Li battery research.

@sweatystartup Plus the controllers they hold leach plastic endocrine disruptors changing their hormones - biosocial engineering

All my dad friends with 10-18 year old sons can’t get them to do anything with them. Want to go camping? Nope. Want to go on a hike? Nope. Want to ride bikes? Nope. Want a girlfriend? Nope. Want to get your license? Nope. They’re all addicted to video games.

abstractsonline.com/pp8/#!/10892/p… We will be presenting at the Society for Neuroscience meeting coming up in DC. Non- antibiotic Tetracyclines modulate Alzheimer’s by Mitochondrial mechanisms- Science didn’t see this coming! Mitochondria are bacteria too!

@BStevensonLab Hi Brian- tried to call you. You keep hanging up - probably think I’m a spam call- wanted to talk about my unique collection of Tetracyclines and how to discover better ones- no problem though. Thanks

@mkaeberlein Tetracyclines, and not the antibiotic kind- affect C elegan- see our work with the Auwerx lab-regulators of mitos and immunosuppression pubmed.ncbi.nlm.nih.gov/35787521/#:~:t….

AI for longevity is only as powerful as the training data. A recent AI/ML study used 80 "senolytics" of which only a few are specific/potent. Not a good training set. Imagine if we had 1000s of validated, large effect size longevity interventions... pubmed.ncbi.nlm.nih.gov/37432607/

@philipcball Not showing chemical structures is where biology stops and medicinal chemistry begins. Had a discussion- let’s just string heteros together- start a company- we all laughed then didn’t.

@BStevensonLab @ItaiYanai Microbiology doesn’t follow week-like rules. Everyday is Monday when running experiments and everyday is Saturday - in my experience

@ItaiYanai I advise my mentees that they can work whatever days and times fit best. Want to work on Sunday when parking is easy and equipment is free? Okay! Want to take Tuesday & Wednesday off, when nobody else is at the beach? Okay! Do your work in a way that makes you happiest.

What does a mentor advise a mentee to do on the weekends? I encourage my lab members to rest but it’s a bit hypocritical because when I was at their stage I worked on the days off (and still do, kind of..). Maybe the best thing is to just make sure there's no expectation to work.

@agingdoc1 @statnews Thanks Mom!

Schizophrenia gene found to be linked to energy dysfunction in brain cells statnews.com/2023/08/16/sch… @statnews

@BStevensonLab @WilsonLab2 E Coli was used. Great paper. Showed binding of the Tet we invented Nuzyra. Still room for better ones I see!

@WilsonLab2 Perhaps you can provide additional information to those of us who don’t have immediate access to the full article? The abstract says you mapped interactions between antibiotics and “the bacterial ribosome”. Which species of bacteria? Ribosomes are not identical across Eubacteria

Structural conservation of antibiotic interaction with ribosomes - PubMed pubmed.ncbi.nlm.nih.gov/37550453/

@billthechemist Hi Bill the Chemist- get to booth 445 and meet our team at CPLab Chemicals and Lab Safety- have a periodic table bag for u and others- go Owls! Glad to see you in Chemistry!

GRS reunion in San Francisco

@drtimothyli Forms quinones on the D ring and condenses too. Good for short term only use.

Minocycline causes hyperpigmentation much more than other tetracyclines Why? ⭐It forms insoluble complexes with iron which causes pigmentation (other tetracyclines tend to chelate calcium) ⭐⬆️lipophilic and ⬆️penetration into different tissues ⭐It turns black when oxidized

The #ACSFall2023 Expo Floor is Open!!! #Chemistry #ChemTwitter