Barbara Arbeithuber

#mdpinutrients Welcome to read the Latest hot articles in Nutrients! dx.doi.org/10.3390/nu1608… dx.doi.org/10.3390/nu1607… dx.doi.org/10.3390/nu1608… dx.doi.org/10.3390/nu1607… dx.doi.org/10.3390/nu1607…

Eizellen von Primaten könnten vor Mutationen geschützt sein - Linzer Forscherin zeigt, dass bei Primaten Mutationshäufigkeit in mitochondrialer DNA von Eizellen-Vorläufern geringer ist und mit dem Alter weniger zunimmt als in Zellen anderer Gewebe go.apa.at/LaTS0stM @jkulinz

Primate oocytes developed a mechanism to avoid accumulating mitochondrial #mutations at advanced age. Read our article @PNASNews. Work by @Arbeithuber, M. Cremona, J. Hester, B. Higgins, K. Anthony, F. Chiaromonte & F. Diaz. @PSUresearch @PSUScience 1/n pnas.org/doi/10.1073/pn…

Led by Eberly researcher @MakovaLab, a new study suggests there may be a protective mechanism that keeps the mutation rate in reproductive cells lower compared to other tissues in primates. buff.ly/3LXRLQD @PennStateBio

Discovery of an unusual high number of de novo mutations in sperm of older men using duplex sequencing biorxiv.org/cgi/content/sh… #bioRxiv

Take a lunch break on Tuesday, learn something new: Du Novo Sequencing by @NickStoler and @Arbeithuber using the Galaxy Pro platform: galaxyworks.io/webinars/

Read our recent paper in @PLOSBiology: Age-related accumulation of de novo mitochondrial mutations in mammalian oocytes and somatic tissues. By @Arbeithuber, J.Hester, M.Cremona, @NickStoler, @A_A_Zaidi, B.Higgins, K.Anthony, F.Chiaromonte & F.Diaz plos.io/3fxpReo 1/n

New mutations accumulate in #reproductivecells of older mice @penn_state @PLOSBiology medicalxpress.com/news/2020-07-m…

Age-related mutation frequency increase in mammalian oocytes. High-accuracy duplex sequencing reveals low-freq, de novo mutations in mitochondrial DNA from oocytes & somatic tissues. Mutation freq can triple as mice age by 9 months @MakovaLab #PLOSBiology plos.io/3fxpReo

Strong mitochondrial bottleneck in each human💇‍♀️hair 💇‍♂️ & increased variance in allele frequency with age. Read our paper royalsocietypublishing.org/doi/10.1098/rs… by first author A. Barrett from @PennStateHonors mentored by @Arbeithuber, with help from @A_A_Zaidi, Wilton, @ianpaulmd, @ras_nielsen

A new study by Eberly's @MakovaLab and a team of @penn_state and @UCBerkeley scientists provides insight into how disease-causing mutations in mitochondrial DNA are passed from mother to child — with important implications for pre-pregnancy counseling 🧬 buff.ly/2rUoUsp

The mtDNA bottleneck can be confusing! The genetic bottleneck is not exactly a physical reduction in mtDNA copy num; can change over time; and is measured in different ways. New article attempts to explain & survey frontiersin.org/articles/10.33… (also seems exciting PNAS on this soon!)

The Participants of the 243rd #ENMC International Workshop 'Developing guidelines for management of reproductive options for families with #maternally #inherited #mtDNA disease' in Hoofddorp, the Netherlands.

A new platform ! It’s been a while. Genapsys is ‘iPad sized’, short read electronic sequencer (100bp?) with Illumina-like accuracy for $10k. Launching later this year. #AGBT19

Our paper with @A_A_Zaidi on Exploring Mito-nuclear incompatibility in #humans was just published online in @NatureEcoEvo. Here is a link to the full-length text: rdcu.be/bgNT8. #mitochondrion @PennStateBio

Read our recent preprint on rapid #satellite #repeat #evolution in great #apes uncovered with the use of @Illumina, @PacBio & @nanopore #sequencing reads. Work by @biomonika, @RSHarrisPSU, @MTdellarte, @Arbeithuber, Francesca Chiaromonte & myself: biorxiv.org/content/early/…

Length asymmetry and heterozygosity strongly influences the evolution of poly-A microsatellites at meiotic recombination hotspots biorxiv.org/cgi/content/sh… #biorxiv_evobio

A high resolution view of adaptive events biorxiv.org/cgi/content/sh… #bioRxiv

Alison Barrett presenting her work on mtDNA heteroplasmies in hair at the Eberly College of Science  Undergraduate Research Poster Exhibition tonight @MakovaLab @PSUScience @PennStateBio

#trimad18 @Kastner4Markus from @CameronLabPSU reports on biochemichal and biophysical analysis of a #TFAM missense variant.