Ben Hobson

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Ben Hobson

Ben Hobson

@BenHobs3

Psychiatry resident @CUAnschutz 🏔️ | 🧠 🧬 🔬 | MD, PhD @columbia 🌃

New York, NY เข้าร่วม Şubat 2019
270 กำลังติดตาม220 ผู้ติดตาม
Sean X. Luo MD PhD
Sean X. Luo MD PhD@seanluomdphd·
@BenHobs3 @chrisaikenmd Jeez lol I mean … sounds absurd. Btw that ?green/blue? light entrainment alz treatment is also falsified. I was really rooting for it.
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Chris Aiken, MD
Chris Aiken, MD@chrisaikenmd·
#Lithium (195 mg) failed to prevent decline (but raised creatinine) in older pts w/ mild cognitive impairment in 2-yr RCT: ncbi.nlm.nih.gov/pubmed/41770546 ▪ Earlier trial was positive in pts w/dementia markers ▪ Maybe underpowered, but if a benefit it is small Evidence Moderate 8/10
Chris Aiken, MD tweet media
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Ben Hobson
Ben Hobson@BenHobs3·
@seanluomdphd @chrisaikenmd Didn’t the mouse paper claim that they had to supplement with lithium orotate instead of carbonate? Something about the sequestration of specific salts in plaques…
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Ben Hobson
Ben Hobson@BenHobs3·
@seanluomdphd @RecoveryDoctor I’ve had patients stop late due to intractable nausea despite liking the medication otherwise and really trying to persist through it. In a couple of other cases, it was not effective enough to keep them out of the hospital
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Sean X. Luo MD PhD
Sean X. Luo MD PhD@seanluomdphd·
Yes but then you and I won’t be able to be like “but clinically what I see is …” like an oracle. 😉 I put 2 people on cobenfy and they both stopped early due to nausea My best current med combo that’s “best” for “low severity schizophrenia” is abilfy+ aggressive glp1. I think you know what I’m talking about. But I’m by no means a scz specialist and only see handful of those a year
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Michael Ostacher, MD, MPH
Michael Ostacher, MD, MPH@RecoveryDoctor·
“Future research should directly compare xanomeline–trospium with other antipsychotics to confirm its efficacy”. Bless them, they did a network meta-analysis of drugs that have never been tested against each other, but at least they said it outright.
Joshua Rosenblat, MD, MSc, FRCPC@JD_Rosenblat

Comparative efficacy and tolerability of antidopaminergic and muscarinic antipsychotics for acute schizophrenia: a network meta-analysis of randomised controlled trials indexed in international English and Chinese databases - @TheLancet thelancet.com/journals/lance…

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Ben Hobson
Ben Hobson@BenHobs3·
@chrisaikenmd I’m surprised to hear it’s apparently so hard to get approval? I have quite a few patients (mostly Medicaid) on them and haven’t gotten much push back on prior auth
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Chris Aiken, MD
Chris Aiken, MD@chrisaikenmd·
Which sleep meds have lowest risk of misuse/withdrawal? The orexin antagonists were safest in new analysis of FDA reports: ncbi.nlm.nih.gov/pubmed/41684517 They also improve next-day cognition and don't cause falls. Anyone have luck getting them approved? Art: Duane Michals
Chris Aiken, MD tweet media
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Ben Hobson
Ben Hobson@BenHobs3·
@RCarhartHarris Can subjects not bring expectation bias into their foray of microdosing, etc? Maybe I misused the term but was conceiving an “individual's expectations about an outcome influence perceptions of one's own or others’ behavior”. But yeah, also selection and recall bias
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Ben Hobson
Ben Hobson@BenHobs3·
@GuruAnaerobic @Bwhite4363 Of the two, Dante August certainly can, he is an 800m specialist and in fact I think he has run 46sec 400m. Paul Chelimo (the one looks smoother and more efficient) is a 5k & up runner and I very much doubt he can run 22 or 48, though I also doubt he has verified race times
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GuruAnaerobic
GuruAnaerobic@GuruAnaerobic·
@Bwhite4363 A mile isn't long distance. Also these guys can run ~22sec 200m and ~48secs 400m
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GuruAnaerobic
GuruAnaerobic@GuruAnaerobic·
This is what being built for running looks like.
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Ben Hobson
Ben Hobson@BenHobs3·
@ahmari_lab Terrible times… the MSTP T32 and F30 are gone as well, both grants that supported my training at Columbia. They can likely overcome the T32 to keep students supported, but I feel bad for students who will likely not be able to go through the F30 application process now
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Ben Hobson
Ben Hobson@BenHobs3·
@dr_alexharris Terrible news… hopefully Vagelos can stabilize things while legal challenges are mounted…
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Ben Hobson
Ben Hobson@BenHobs3·
@BadreNicolas This does not reflect the ideology or training environment of my residency at all
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Nicolas Badre
Nicolas Badre@BadreNicolas·
A resident quoted a psychiatry chairman saying, "Therapy is for social workers. It is not real psychiatry," in response to slashing therapy training. ACGME, which oversees psychiatry training, must enforce psychotherapy education, or our profession loses its humanity.
The Loneliness Doctor@Loneliness_Doc

@BadreNicolas Have you ever noticed how many of your colleagues are downright allergic to emotions? Often it makes sense when you get to know their personal learning hx. They sublimate by carrying around an arsenal of chemical agents to spray at and hopefully extinguish the emotions.

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Michael Ostacher, MD, MPH
Michael Ostacher, MD, MPH@RecoveryDoctor·
It's just really, really weird that people are touting this treatment, xanomeline-trospium, for schizophrenia without a single study showing whether it works as well as the standard treatments for schizophrenia. Shouldn't showing that first be required?
Psychiatrist.com@PsychiatristCNS

🔬 A JCP study reviews the newly approved xanomeline-trospium combo. Unlike traditional antipsychotics, it targets muscarinic M1/M4 receptors — reducing dopamine in key brain areas without blocking D2 receptors. 🚨 The catch? Potential GI issues, anticholinergic effects, & cardiovascular monitoring needs. bit.ly/3QAo5xh

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Ben Hobson
Ben Hobson@BenHobs3·
@RecoveryDoctor No doubt, my guess is if they had a 3rd arm of haldol or zyprexa in the trials then cobenfy wouldn’t look so great. Cobenfy isn’t going to be on formulary on our inpatient units for a long time, so I don’t know anyone with any direct experience using it.
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Ben Hobson รีทวีตแล้ว
AJHG
AJHG@AJHGNews·
📣 New today! 📄Genome-wide prediction of dominant and recessive neurodevelopmental disorder-associated genes 🧑‍🤝‍🧑@RyanDhindsa @awzoghbi & colleagues cell.com/ajhg/abstract/…
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Ben Hobson
Ben Hobson@BenHobs3·
@Roy_Lab_Thinks @JasonSynaptic His last tweet was “Tinkering with human embryos will certainly be worth the risk” which is simultaneously 😮 and 😂
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Robin Carhart-Harris
Robin Carhart-Harris@RCarhartHarris·
Age regressions under psychedelics. Quite common in the old literature. Seen/experienced any in more modern times?
Robin Carhart-Harris tweet mediaRobin Carhart-Harris tweet media
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Rai Benjamin
Rai Benjamin@_Kingben_·
200 retweets and I’ll do the 200/400 double at worlds…. I’ll beat Noah and Vernon 😂🤝🏾… Grant also gotta see me in the 110 too.. I’ll take the stripes off his lil vest
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Ben Hobson
Ben Hobson@BenHobs3·
@curious_cynic @mbeisen Completely agree… signing up for grad school in bench science without any experience?? No pubs is fine. But admitting a bunch of successful athletes/artists/etc who have no idea what it’s like to work in a real basic science lab is asking for failure and many dropouts
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Mel B, Ph.D.
Mel B, Ph.D.@curious_cynic·
@mbeisen the thing is, I've seen ugrads join a lab & decide off that experience, that benchwork isn't for them. I guess the thought is for them to have that experience 1st, to setup expectations for grad school. Nothing else is like it.
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