Caleigh Guoynes

Writing retreat 2023!

During motherhood, females spend all their time caring for the young. However, nearly 100% virgin female mice in the wild kill pups. In our new study published today @Nature, we revealed the neural circuit responsible for this drastic behavior switch. rdcu.be/ddZgF

Our sensory systems are our body’s interface with the world. Check out our new paper investigating age-related differences in the eyes of free-ranging rhesus macaques, led by the excellent @ag_fernandes1.

Very excited to share our new work using unsupervised machine learning to characterize family specific vocal usage in the Mongolian gerbil! biorxiv.org/content/10.110…

Congratulations to Caleigh Guoynes (@CGuoynes)! IN OXT enhanced social preference for parents in male but not female peri-adolescent mice. IN AVP did not influence social preference in either sex authors.elsevier.com/c/1ga~-3oGhVqKb

Ever wondered how #oxytocin and #vasopressin affect parent-offspring bonds around weaning age? Me too! Was excited to find out that OXT enhances male but not female preference for their parents (and AVP has no effect)! Check it out: sciencedirect.com/science/articl… @Marler_and_Lab

A timeless model for writing a good research summary.

I am happy to share with you all my first PD paper from the @Froemkelab. Here we leverage chemistry to spatiotemporally control oxytocin binding in neuronal and non-neuronal tissue. A fun collaboration with the Chao, Tsien, @DirkTrauner, @DrYassum, @felicitydavis2 labs!

@TheBrandyWilcox I am so so sorry to hear this. I have not gone through this myself, but I know he loves you and will love you no matter what. Maybe that’s spending a small fortune on cancer therapy—or maybe it’s dozens of walks, cuddles, treats, toys, and extra time spent at home. *hugs*

At what point do you decide that treating a pet is “too expensive”? Presley has cancer and the only thing that might work are drugs that cost almost as much as my rent each month. How on earth am I supposed to come to terms with that?

Happy to see this collab out! It was a pleasure to work with the supremely talented @lindsaywillmore and @IlanaWitten . This project has really been the force that launched 1000 ideas/experiments for the lab, so stay tuned. nature.com/articles/s4158…

New paper out today! @JosephTanas used multidimensional analysis (PCA + k-means clustering) to quantify behavior in #Angelman mice. This approach can be used to help evaluate AS therapies preclinically. nature.com/articles/s4139…

New paper! We used the 5CSRTT to assess attention + impulsivity in #Angelman model mice. (Tricky, because these mice also have motor impairments.) @paola_negmo (+@CGuoynes @ddi3p) figured out a clever way to dissociate motor from non-motor phenotypes. frontiersin.org/articles/10.33…

Intranasal oxytocin enhances social preference for parents over peers in male but not female peri-adolescent California mice (Peromyscus californicus) biorxiv.org/content/10.110… Examining effects from the perspective of young that are close to weaning age @CGuoynes @Marler_and_Lab

@ESRothwellPhD @AL_marmo @brettmfrye @1749_336 @NIHAging @HofLab Congrats, Emily!

Very excited to share my postdoc work @Nature on elucidating the role of neurotensin in guiding valence assignment in the amygdala, under the guidance of @kaymtye at @salkinstitute @HHMINEWS, and in collaboration with @praneethnamburi and @jakemolson nature.com/articles/s4158…

I’m excited to share that our paper is online today in @Nature. We investigate how animals learn what foods and fluids hydrate them. Sincere thanks to my mentor @zaknight and thanks to collaborators @berke_lab and @AnatolKreitzer. (1/6) nature.com/articles/s4158…

Here is my #firstauthor paper from my #PhD! 🎓🇩🇪We showed how #plasmamembrane proteins regulate the interplay between #calciumclearance and #calciumentry in neurons. 🧠🔬 authors.elsevier.com/a/1fQNMWc%7Eb2…

My thoughts on the Supreme Court's decision to overturn Roe v. Wade.

If this was about babies, there would be universal healthcare. Free education. Free daycare. Southern states would be doing all they can to drop the Black maternal mortality rate. This is about power and control