Castaneda Lab

Phase separation of polyubiquitinated proteins in UBQLN2 condensates controls substrate fate: pnas.org/doi/10.1073/pn… New publication with Dan Kraut's lab at Villanova where we look at proteasome and deubiquitinase recruitment and activity in UBQLN2 condensates!

Welcome aboard @shaharsu ! So excited to have you here and forge new scientific directions!

Super grateful to our lab and our fantastic collaborator Dan Kraut and his wonderful team!

And promiscuous deubiquitinases (DUBs) can exhibit linkage-dependent activities in the presence of UBQLN2-polyUb condensates (e.g., K63-Ub4 is protected from DUB activity - black curves below)

Phase separation of polyubiquitinated proteins in UBQLN2 condensates controls substrate fate: pnas.org/doi/10.1073/pn… New publication with Dan Kraut's lab at Villanova where we look at proteasome and deubiquitinase recruitment and activity in UBQLN2 condensates!

Super happy to see the final version of our paper on the role of NAP1/SINTBAD in PINK1/Parkin mitophagy! @NatureSMB Read the full paper here: rdcu.be/dLQgH

Super excited to have you as one of our Biology colleagues @SUArtSciences ! Go #IDPs! Looking forward to all the cool ideas that come out of your lab integrating IDP biophysics and plant biology! Welcome aboard!

Super excited to have you as one of our colleagues @SUChemistry @SUArtSciences ! Welcome aboard! I second everything you've written in your thread. We will do our best to help drive your awesome science and collaborations! #IDPs

We had a blast helping out @PattesonLab with #localizationmicroscopy and #zeissAiryscan in @Castaneda_lab and @SU_BioImaging. Paper looks great! nature.com/articles/s4200…

Recipes. Recipes that are more than their ingredients. Recipes written by hand and lost to time. Can now be analyzed and resorted using the power of Dell AI. Preserving memories and helping to write new ones. @Intel

@BanerjeeLab_UB You are an amazing host @BanerjeeLab_UB !!! Fantastic visit. You are doing amazing science and I feel very lucky to start a collaboration with you and your lab! To 2024 and beyond!!

Happy New Year to everyone here!! 2024 is off to a good start with my dear friend and awesome colleague Carlos @Castaneda_lab visiting Buffalo. Here I and Carlos in our C-Trap room making New Year resolutions to do some cool dynamic single-molecule experiments together 😎

My lab jokes that IAA does not stand for 'indole-3-acetic acid', but rather for 'involved in almost anything'. Here is a recent review from us on connections between auxin and abiotic stress. academic.oup.com/jxb/article-ab…

Grateful to @SUBiology colleagues like @LovelessRadio for getting us into microscopy and cell work many years ago!

#cellbio2023 ASCB attendees - interested in #UBQLN2 #condensates and their roles in cell stress response? Visit Anitha's poster on Sun 12/3 (P1589) to hear about heat stress in cells, while Billy presents on UBQLN2 puncta formation with the @oniHQ nanoimager (P1594)!

Recruiting #PhD Bio students to @SUBiology ! If you're at @ABRCMS , come talk to current grad Savannah from @sarah_hall02 lab, and undergrad Alana from @YazBraimah lab! @drhougs has all the info - learn about @SUBioInspired , Neuroscience & our growing dept! (apply by 1/4/24)

Interested in understanding how and why IDRs matter for cellular function? @BBKrage and I took a deep dive into this question and – with excellent feedback and critiques from colleagues & our amazing editor – put together our perspective on this: nature.com/articles/s4158…

Please RT! 🔬Join the #KohlerProteostasisLab! We have a fantastic opportunity for a #PhD position in #MedicalScience! 🎯Our goal: Uncovering the #MolecularProcesses behind age-related #Diseases, with a special focus on #Proteostasis during #Ageing 🔍 Interested? Read more =>

NMR of glutamine-rich prion-like domains in a condensed phase - new stuff from Sandy Wang and @TongyinZ . Structure and position-specific interactions of prion-like domains in transcription factor Efg1 phase separation biorxiv.org/content/10.110…

@SUBiology will be at @ABRCMS next week to represent our #PhD program! Amazing lineup attending: @drhougs himself, grad student Savannah from @sarah_hall02 lab, and undergrad Alana from @YazBraimah lab will be there! More soon!