EustermannLab

Two independent #cryoEM studies on hexasome remodeling reached similar conclusions. @EustermannLab @EMBL sends congrats to @yifan_ucsf and Narlikar Labs @UCSF! This is how Science should be @ScienceMagazine science.org/doi/10.1126/sc… science.org/doi/10.1126/sc…

Congratulations to Michael Dorrity of @embl, Heidelberg, Germany on being awarded a FEBS Excellence Award, which provides €100,000 in research funding @mwdorr #FEBSExcellenceAwards febs.org/news/febs-exce…

New work from the lab! James Stowell led this project showing the importance of multivalency and phospho-regulation in mRNA decay. This has many parallels with other mechanisms in gene expression... 🧵 1/ #RNA #NMR #bioRxiv @MRC_LMB @ERC_Research

A huge shoutout to our #EMBOCryoEM participants! 👏 The last 9 days were full of lectures, practicals, and social activities - well done for showing up each day with renewed enthusiasm and making this course memorable ✨ See you again soon? 👉 embl.org/events

Our latest paper is out today @MolecularCell! Led by a @AHA_Alberto and with important contributions from @SaricLab & @EllenbergLab! We show how chromosomes shift from being repulsive to becoming attractive during mitosis. Read all about it here: cell.com/molecular-cell…

1/ 🤔 Do #chromatinlooping-mediated promoter-#enhancer interactions drive gene expression? Or is the local enrichment of transcription factors into hubs/#condensates the key factor? Our AC/DC model of gene regulation at bioRxiv doi.org/10.1101/2024.0… provides a new view on this.

Happy to share with the world that the main body of my PhD thesis (and my rotation project) on the mechanism for replisome-mediated parental histone inheritance is published in @CellCellPress today🥰! cell.com/cell/fulltext/…

BIG NEWS No 2 🥳🥳🥳 ! Together with @PLID_Info @DiabResearch @HelmholtzMunich @tudresden_de and @Medizin_TUD As of April 1st @ingmarschafer of @LabConti and @MPI_Biochem is appointed as Professor and Chair of Structural Membrane Biology at PLID and ZML.

This is an amazing course with an all-star lineup of instructors 🤩 It will cover the theoretical and practical foundations of advanced cryoEM techniques, from sample preparation to data collection to image processing. You have one month to apply!

The simple autophagy adaptor protein Atg18 has many levels of structural self-organization in particular with lipid membranes! Wonderful collaboration with the Andreas Mayer lab (Lausanne) and with two leading authors @FrommSimon @proteincommandr . doi.org/10.1038/s41467…

Congrats @BrahmaComplex!!! The BAF chromatin remodeler synergizes with RNA polymerase II and transcription factors to evict nucleosomes nature.com/articles/s4158…

1/10 With great pride I present our newest #CryoEM work pub. in @Nature. The 1st reported secondary-active transporter directly activated by membrane voltage. Full credit to the amazing @VKalienkova, @MartinPeter91 & @rheinbergerj 🧵👇🏽 for more info nature.com/articles/s4158…

Super excited to present #Blush and with it expand the applicability of cryo-EM. We reconstruct one of the smallest complexes ever with cryo-EM. A 40 kDa protein-RNA complex. biorxiv.org/content/10.110… But how do we make sure we’re not overfitting? 🧵1/4

EMBL researchers have provided the first detailed structure of human RNA polymerase III transcription factor IIIC (TFIIIC). The findings offer vital insights on TFIIIC’s cellular functions to those studying its role in chromatin organisation and cancer. science.org/doi/10.1126/sc…

Special thanks goes to Min Zhang @ChowderMin, Anna Jungblut @EustermannLab and Franzi Kunert @ @hopfnerlab science.org/doi/10.1126/sc…

How to remodel a hexasome? Check out our new findings on non-canonical nucleosome remodeling @ScienceMagazine. Great @EustermannLab team effort @EMBL together with @hopfnerlab and Frank DiMaio. science.org/doi/10.1126/sc…

New EMBL research by the Eustermann lab reveals how the packaging of DNA into hexasomes impacts the function of remodeling enzymes involved in gene regulation. Read more: science.org/doi/10.1126/sc…

Check out how the INO80 complex interacts with non-canonical nucleosomes. Great team effort by M. Zhang, A. Jungblut and F. Kunert. Congratulations to the @EustermannLab @embl and all authors!!! science.org/doi/10.1126/sc…

How are genomes neatly packaged for cell divisions? Our awesome collaboration with @HaeringLab @EMBL @Uni_WUE reveals intriguing #cryoEM insights into the mechanism of DNA loop extrusion by SMC complexes: embl.org/news/science/s…