Frydman Lab

Another great story from Jae Ho Lee in the lab: a new concept in cotranslational proteostasis-ribosome communication via chaperoneNAC. An exciting collaboration with Elke Deuerling's lab @DeuerlingLab and Marina Rodnina's lab biorxiv.org/content/10.110…

New exciting work from Jae Ho Lee in our lab, in a fantastic collaboration with Alessandro Ori @AOri_lab and Alessandro Cellerino @Alessan82703458 on why and how the brain ages and becomes vulnerable to neurodegenerative diseases science.org/doi/10.1126/sc…

Paging @NIHDirector_Jay . Is abruptly cutting these grants going to "make America healthy again"?

Triglycerides are an important fuel reserve for synapse function in the brain go.nature.com/4nvjk7k

I stand with dozens of other biopharma leaders highlighting the potential catastrophic effects of proposed research cuts on bringing innovation to patients! statnews.com/2025/06/27/bio…

My NIDA grant renewal is almost 2 months late and I’m going to have to start firing my students and staff. Not a lot of transformation to be had in my lab.

Our lab at the Weizmann Institute was hit tonight by Iran We will rebuild and return 💪

@JSheltzer Such great news! Looking forward to many opportunities to collaborate and discuss science looking

I’m thrilled to share that I’m joining the faculty at the Stanford University School of Medicine. My lab and I will be relocating to Stanford this summer!

@SergioCruzLeon1 @jpkreysing @MarinaLusic @Beck_Laboratory @MPIbp This is incredible! So incredibly cool and important. Congratulations!

Excited to share our pre-print on the molecular architecture of heterochromatin in human cells🧬🔬 w/ @jpkreysing, Johannes Betz,Turoňová lab, @MarinaLusic, Hummer lab, @Beck_Laboratory, @MPIbp 🔗 Preprint here: doi.org/10.1101/2025.0…

@SamantLab Congratulations! Being a fellow Luddite myself I commiserate, but don't miss the irony I do so on social media. Looking forward to many more PhD thesis to come from your lab!

Lab’s first #PhD thesis submitted (congrats Yasmeen 🎉)! Anyone else remember, in the paper age, having to get a physically-stamped receipt from the library with the date and time? Any other quirks/rituals you miss that I can add to my Luddite lament?

It was a pleasure to participate in the "Protein folding & Chaperones" platform session this morning in #bps2025 sharing our story from the @FrydmanLab about TRiC mutations and their link with brain malformations. A session with a nice mix of cool stories focused protein folding

Closing an unforgettable chapter at Stanford. Grateful for the science, the growth, and the incredible people who shaped this journey—especially Judith, with whom I had the privilege of doing great science. This place and its people will always mean a lot to me. Very excited!

@nmr900 @LEK_Lab @UofT @EASorg December 4 Webinar | 10 a.m. - Noon EDT via @ProteinSociety mailchi.mp/proteinsociety… Congratulations on this super deserved award!

Professor Lewis E. Kay @LEK_Lab @UofT to receive the 2025 EAS @EASorg Award for Outstanding Achievements in Magnetic Resonance eas.org/eas-award-for-… #NMRnews #NMRchat #NMR 🧲

@HuaipengXing @Beck_Laboratory @goetheuni Congrats Dr Xing! A brilliant future awaits!

@Beck_Laboratory @goetheuni Thank you, Martin, for your incredible supervision throughout this amazing PhD journey. It has been an absolute pleasure working with so many brilliant people in the lab, making the experience truly enjoyable and memorable😊

Congrats to @HuaipengXing for defending his PhD. First PhD hat @goetheuni 😎

3) Two surprises that could only be revealed by cryoET raise new cool future questions (I) It uncovered a new cofactor, PDCD5 which binds to ALL open TRiC complexes (and was missed by biochemical studies) and (II) closed TRiC forms stereotypic clusters of mysterious function.

2) The MS also quantified TRiC-Prefoldin cooperation in vivo. Importantly it establishes that closed TRiC engages in specific interactions with quasi-folded substrate folding intermediates in its closed folding chamber, which is clearly NOT an "Anfinsen cage"

Check out our MS describing the in vivo cycle of chaperonin TRiC/CCT, in a wonderful collaboration with Martin Beck's lab: nature.com/articles/s4158… 1) The study established TRiC's important function in folding newly translated proteins and defines its ATP-driven cycle

@Beck_Laboratory @HuaipengXing @Nature Congratulations Huaipeng and Martin for this super-exciting collaboration and to all of the Beck lab for the warm welcome and hospitality during my sabbatical in Frankfurt last year! Not every day one discovers a new major chaperone cofactor, and from cryoET density no less.

… and perfect timing. Work by @HuaipengXing with @FrydmanLab out @Nature. PDCD5 binds virtually all open #TRiC, while closed TRiC forms clusters inside of cells. Congrats to all authors. rdcu.be/d3dmN

A really nice piece on our recent study: med.stanford.edu/news/all-news/…

@CAMBUpenn @ErikaHolzbaur what a great paper!

Paper alert! Adam Fenton alum of the Holzabur @ErikaHolzbaur and Jongens labs. Congratulations🎉 nature.com/articles/s4155…