Goriely Lab

Our lab, together with others, have secured funding for a project titled “Making it personal”, which uses theatre to explore public perception of a new form of genetic testing. Read more below.... imm.ox.ac.uk/news/PCER-awar…

@RodTMitchell @MRC_WIMM @DrMike_Rimmer @GraceForsyth13 @DuffinKathleen @UniofOxford Absolute pleasure to host @RodTMitchell for fantastic talk Wonderful work from his team! And very generous content describing mainly unpublished work. Than you do the visit!

An absolute pleasure to be invited to present on #FertilityPreservation in boys @MRC_WIMM guest speaker seminar series. Fantastic to be able to share the work of our team (@DrMike_Rimmer @GraceForsyth13 @DuffinKathleen) and catch up with several of our collaborators @UniofOxford

Introducing our latest paper (doi.org/10.1111/andr.1…) : "can the male germline offer insight into mammalian brain expansion?" Its contents in brief: we think so.

The genes that influence menopause timing are also linked to cancer risk and newly arising mutations in egg cells. Balancing the benefits of future treatments to extend fertility with the potential risks will be important, says @GorielyLab. go.nature.com/4d4sUYq

🚨 Job alert Hiring a postdoc (comp or wet lab) to work on chromatin & genetics 🧬 Come work with us @HumanGeneticsOx in the beautiful @UniofOxford 🗓️ Closing September 13th Details at beagrielab.com/join Pls share and RT! #PostdocJobs #GeneticsJobs #genomics #cohesin

After a few years of work, we have identified the first non RAS/MAPK pathway gene which is under 'selfish selection' in the male germline. With implications for those with @MyhreSyndrome, our seminal work is published in @AJHGNews

With thanks to the patients, clinicians, collaborators and authors for all their support on this collaborative project!

SMAD4 is the first PAE gene operating outside the RAS-MAPK pathway @RASopathiesnet. This finding raises the exciting possibility that other genes and signalling pathways may be under positive selection in the male germline.

Hot off the press! Our latest publication “SMAD4 mutations causing Myhre syndrome are under positive selection in the male germline”, is out today in @AJHGnews! tinyurl.com/889mn4mj – the result of a fruitful collaboration with the Tartaglia lab in Rome

We wish @educalpena all the best on his PI endeavours in Valencia. His wealth of knowledge and infectious personality will be missed!

We are grateful to all our participants and to our funders @OxfordBRC @Wellcometrust for making this research possible. Thank you also to our reviewers and editors at The Journal of Genetic Counseling for giving us the opportunity to share our findings. 10/10

A further finding is that giving personalised risk information with a non-directive approach may create patient burden. Securing understanding for autonomous decision-making may be hard to achieve and couples may want more guidance. Research with couples is planned. 9/10

Pregnancy decisions can be hard after having a child w/ a genetic condition. Latest @Gorielylab research on a new strategy:“Professionals’ views on providing personalized recurrence risks for de novo mutations”@AliMakesHay JWells @AGoriely NHallowell bit.ly/4cgOr0o 1/10