Ignatova Lab

@rubenlgonzalez @Nature Congrats Ruben! Terrific stuff!

Our latest work is out in @Nature today! Using smFRET, we directly visualized recruitment of the eIF4F complex to the 5' cap of eukaryotic mRNAs and formation of an activated mRNA. Our findings reveal new and surprising roles for each eIF4F component. 1/3 nature.com/articles/s4158…

The official website for the tRNA2024 Conference has been updated! You can now find the latest presentation schedules, session details, and notification to oral/poster presentation. Stay up to date and plan your presentation: trna2024kanazawa.jp #tRNA2024

That's what the pluripotent stem cell field has been waiting for. Own cells, reprogrammed to iPSCs; differentiated into insulin-producing cells, and translanted back into patient, effectively curing type-1 diabetes! One patient. One year. But a tremendous proof-of-concept.

Highly recommended! PhD students apply

At Tevard, we're devoted to improving the lives of people with severe genetic diseases like Duchenne muscular dystrophy (DMD). In honor of #WorldDuchenneAwarenessDay, learn more about DMD, and see how you can help raise awareness: bit.ly/3qh209B #WDAD24

Preprint alert in collaboration with @fraser_lab ! We identify that deleting GidB, a 16S rRNA methyltransferase, acts as an "automatic braking system" for mistranslation! Ribosomal RNA methylation by GidB modulates discrimination of mischarged tRNA biorxiv.org/content/10.110…

We're looking forward to the upcoming RNA Leaders USA Congress. Tevard CEO, Daniel Fisher, will give a presentation on our work to pioneer novel tRNA therapeutics and how our platform is enabling us to advance our pipeline. See the full agenda: bit.ly/3T9n295 #RNALeaders

We report many proteins not predicted by the genetic code. They are stable & abundant O( 10³ ) copies / cell. Generative mechanisms include codon-anticodon mismatches & RNA modifications. Their abundance depends on codon frequency & protein stability. biorxiv.org/content/10.110…

Single-cell proteomics helped answer a fundamental question in development: The molecule mechanisms of symmetry breaking in early mammalian development. A great collaboration with @MZG_Lab led by @aleks_petelski & @LIwamotoStohl.

@DjuranovicLab What fo they tell us, besides being more :)

More ribosomes...yeast, c.elegans and human (+harringtonine)...soon more

How to repurpose a #tRNA enzyme into a global stress sensor? Co-led by @CharlesBNader, Swati Gaikwad, Soheila Bahmanjah, w/ Alan Hinnebusch lab, in @PNASNews, we describe how stress kinase Gcn2 adopts and molds Histidyl-tRNA synthetase as a regulatory hub. bit.ly/3YQbiMk

@JanUlrikDahl1 @IllinoisStateU @ISUResearch Awesome Jan! It not only rains on your street, it poors - hsppy for you! Looking forward to seeing you soon in HH and catching up :)

I’m happy to share that besides being promoted to Associate Professor @IllinoisStateU also trusts me to become the inaugural Dr. Fred Gletten Endowed Chair of Biological Sciences! Off to more exciting science with talented trainees from around the world! @ISUResearch

I am very proud of the superstar postdoc @Yang_Haojun_01, who discovered how to translation control underlying fasting and ketogenic diet in health and cancer. nature.com/articles/s4158…

@MiriKrupkin @D_Rothschild_ @mbarnalab @jkpritch @xsui98 @WangXiaoLab @spence_jeffrey_ Congrats Daphna!

@D_Rothschild_ @mbarnalab @jkpritch @xsui98 @WangXiaoLab @spence_jeffrey_ Congrats Daphna! Fantastic research! 👏👏👏

My postdoctoral work is finally out! Please consider retweeting. I am very proud of this project. I want to thank my wonderful advisors @mbarnalab and @jkpritch and collaborators Theo Susanto, @xsui98, @WangXiaoLab, @spence_jeffrey_, and many others for a major team effort!

Nature research paper: The ribosome lowers the entropic penalty of protein folding go.nature.com/4clH1rM

@chofski @BristolUni @BristolBioSci @BrisBioDesign @JGIBristol @turinginst @royalsociety Congratulation, Tom! Fully deserved!

Happy to announce that I’ve levelled up to a Full Professor of Biological Engineering 🥳 Thank you to everyone that has supported me over the years and the many students/postdocs that have taught me so much. Doing science is tough but the discoveries and people make it worthwhile

Happy (t)RNA day! #RNADay Thank you to our first author baker Vale @Vblancoca - our terrific guest from @jptosar lab - who orchestrated the baking process.

@OdedRechavi Cool stuff! Can you deliver other macromolecules? Small RNAs?

It took more than a DECADE... but finally it’s published!!! It started as a CRAZY idea but after tons of hard work we built it: We hijacked the endogenous secretion systems of Toxoplasma gondii, a brain parasite, to deliver active proteins to neurons 👇 nature.com/articles/s4156…

The time to think and inquire are precious. Inquiring means to contemplate a problem without needing an immediate answer, to sit in the unknown long enough that different kinds of answers emerge. Important part of the process of discovery. nature.com/articles/d4158…