Kalsotra Lab

New Online! Signal control during tissue regeneration in adult animals bit.ly/3XnzvHP

Dysregulated RNA splicing impairs regeneration in alcohol-associated liver disease | Nature Communications nature.com/articles/s4146…

Drs. Anna Mae Diehl & Auinash Kalsotra led this study reporting that in alcohol-associated liver disease, alterations in the hepatic immune milieu prevent #hepatocytes from transitioning to proliferative progenitors. 👉 go.nature.com/3VfAyst

📰DNS Faculty in the News! Dr. Auinash Kalsotra’s team shows how disrupted RNA splicing halts liver regeneration in alcohol-associated liver disease 🔗Read more: tinyurl.com/AuinashK #NutritionalSciences #DNSatUofI #interdisciplinary #research #DNSfaculty #LiverHealth

What movie is 10/10, yet hardly anyone has heard of it?

Beautiful work, congrats Eddie!

“To write for impact means to keep it as simple as possible.” Good read and very insightful. nature.com/articles/s4158…

In this study, Bangru et al. describe a regulatory switch that controls hepatocyte polyploidization and maturation through the activation of an RNA alternative splicing program that promotes cytokinesis failure and binucleation. Learn more here: ➡️ tinyurl.com/gd352129

A naturally occurring molecule identified by Stanford Medicine researchers appears similar to semaglutide — also known as Ozempic — in suppressing appetite and reducing body weight. stan.md/3Xv96bw

🚨 New research from @KalsotraLab uncovers how ESRP2 drives hepatocyte maturation & polyploidization via the microRNA-122 axis—key for liver #regeneration & #disease resistance. Findings could boost efforts in #regenerative #medicine. @NIAAAnews @czbiohub genesdev.org/cgi/doi/10.110…

We have to stand up for science! Anyone who can join these rallies and believes that US science must be protected should come!

This is like AlphaFold, but for protein localisation rather than folding It's a deep learning model that predicts a protein's subcellular compartment based on its amino acid sequence alone:

@MCB_Illinois covers new research from @KalsotraLab mcb.illinois.edu/news/2025-01-3… @sushantbangru @KalsotraAuinash @DuncanWAndrew @DasDiptatanu @UllasChembazhi @SandipChorghade @_WaqarArif Russ Carstens, Jackie Chen, Nick Baker, JessicaDerham @CancerCenterIL @UofIResearch @GenesDev @NIH

Thank you @sarakosman @NatureSMB for featuring our two studies on #MALAT1 & #NEAT1 on the Nov cover! Led by @IliasSkeparnias we describe how #lncRNA partially mimic #tRNA structure for their maturation and #mascRNA #menRNA biogenesis. nature.com/nsmb/volumes/3…

We live in incredible times.

Evidence of RNA polymerase III recruitment and transcription at protein-coding gene promoters dlvr.it/TG6q0F

AlphaFold can predict protein, DNA, or RNA complexes.. BUT is it easy to determine the reliable interactions?🤔 ➡️ AlphaBridge will identify the most confident interactions, making your analysis easier! 🌐Try it here: alpha-bridge.eu 👀Read more: biorxiv.org/content/10.110…

We are excited to announce that the RNA 2025 Annual Meeting website is live! #RNA25 www2.rnasociety.org Limited rooms are available at a special RNA 2025 rate to stay at the beautiful Town and Country Resort & Convention Center, so please book today! www2.rnasociety.org/conferences/rn…

www2.rnasociety.org Check it out! The RNA Society 2025 Meeting Site is now live! Registration will open in January @RNASociety Note the fabulous artwork by former @EmoryBCDB student Dr. Carly Lancaster- make your plans now to join us in San Diego May 27-June 1, 2025