L.D. Lord

Covert Consciousness in the ICU A review in collaboration with @Menon_Cambridge Thank you @CritCareMed for highlighting this topic, now even more relevant after yesterday's @NEJM paper (nejm.org/doi/full/10.10…) journals.lww.com/ccmjournal/abs… @MGHNeuroICU @MGHNeuroSci @MGHNeurology

The brain is metabolically hungry but most accounts of cognition do not consider the energy cost of neural activity Here we review the metabolic budget of neural homeostasis + cognition; associated evolutionary constraints; plus disturbances in disease osf.io/preprints/osf/…

'Unravelling consciousness and brain function through the lens of time, space, and information' by Andrea Luppi @loopyluppi, @_Fernando_Rosas, @PedroMediano, Athena Demertzi @ADemertzi, David Menon @Menon_Cambridge & Emmanuel Stamatakis @estamatakis cell.com/trends/neurosc…

Latest one out! Ultrafast, lossless analysis methods for high-dimensional time-series - application to neuroimaging. First for @GAlteriis, congrats for seeing it over the line :-) and with @FranHancock1, @eilidhmacnicol, @brain_kcl, Federico Turkheimer

Prognostication in the ICU is an uncertain art and science. With @dbfisch, we review the state-of-the-science in our field and where we are heading in @JAMANeuro: jamanetwork.com/journals/jaman… @MGHNeuroICU @MGHNeuroSci @MGH_CNTR @PennNeurology @CuringComa

Psychedelics have started to show promise for treatment of depression. We wanted to understand what causal mechanisms are relevant in driving this success. Our latest brain comms paper attempts to shed light on it. academic.oup.com/braincomms/adv…

New paper out investigating the effect of anesthesia-induced loss of consciousness on the integration/segregation balance (tinyurl.com/5bsy28vd) lead by the fantastic @LDLord13, with @teo121270, @henrique_frnnds and Federico Turkheimer, supported by @imera_amu

New preprint! This is the last chapter for my PhD dissertation to see the light of day: I wrote it to be an accessible introduction to information theory explicitly written for the aspiring complex systems scientist. 1/n arxiv.org/abs/2304.12482

What is the best test to detect consciousness in the ICU? Behavioral exam? fMRI? EEG? Or is it TMS-EEG? We discuss the potential for TMS-EEG measurements of brain complexity to improve care for patients with severe brain injuries in the ICU. link.springer.com/article/10.100… @CuringComa

How to do a principled stimulation paradigm? We argue for "Dynamic Sensitivity Analysis" where in-silico whole-brain perturbations are leveraged in guiding experiments. sciencedirect.com/science/articl… @Joana_Cabral__ @Castaldo_Fr @ysanz6 @LDLord13 @henrique_frnnds @LitvakVladimir

@Joana_Cabral__ @ABIM_CH not exactly a surprise -- you're one of the best in the game Joana! 😊🧠🌟

It's so rewarding to see people enjoy listening to my thoughts! 😊 I'm getting addicted to this 💫 Thanks @ABIM_CH for the oportunity!

Big paper day! Our first data showing that fMRI can be used diagnostically and prognostically in acutely unresponsive patients in the ICU. @lorettaenorton @karnig_kazazian @jpeelle @DebickiDerek @daviniaferes and others (not on twitter). onlinelibrary.wiley.com/doi/10.1002/an…

Brain rhythms have been detected for a century, but their generative mechanisms remain under debate. Here's our hypothesis and how we tested it (1/6) nature.com/articles/s4200… @Castaldo_Fr @VohryzekJakub @LitvakVladimir @RenaudLambiotte @BickMath, Friston, Kringelbach & Deco

The ultimate test of your knowledge is your ability to convey it to another.

New preprint out: "Altered dynamical integration/segregation balance during anesthesia-induced loss of consciousness" biorxiv.org/content/10.110… With the legendary: @LDLord13 @teo121270 @henrique_frnnds and Federico Turkheimer and support from @imera_amu

@MBritoNeuro fully agree with your observation -- you may find the following interesting 🙂: biorxiv.org/content/10.110…

There is a lot of information to be gleaned in the neurophysiology and neurochemistry of the brain using the broad spectrum of brain states ketamine can create - especially as it pertains to the neural correlates of consciousness.

Ketamine gets a lot of attention, but I don't think we put enough emphasis on how crazy it is that a single molecule can take you from rich dissociative hallucinations to complete anesthetic oblivion, with dynamics comparable to both classical psychedelics & GABAergic anesthesia.

"Altered dynamical integration/segregation balance during anesthesia-induced loss of consciousness" 🧠 in collaboration with: @ExpertPol @teo121270 @henrique_frnnds and Prof. Federico Turkheimer supported by @imera_amu 🇫🇷 biorxiv.org/content/10.110…

The bad news is not everyone will agree with your opinions or decisions. The good news is it doesn't matter.

A long-waited paper coming from our long term collaboration with Bechir Jarraya's lab. This time we used DBS to induce anesthesia awakening. We measured the impact in behavior, static/dynamic fMRI FC, and EEG. A proper thread next monday! science.org/doi/10.1126/sc…