Nathan One

After 20 years in telecom and Big Tech, here's what I learned about how empires fall. 🧵 I spent 20 years turning around telecom operations and scaling teams inside Big Tech. Grew an org from $1B to $3.2B. Ran turnarounds where people's livelihoods were on the line. Here's what I learned about how empires actually die.

@alphafox I am not a bot Oh crap this is harder than I expected

I have lost 7K bot accounts during this purge. Say something a bot wouldn’t say so i know your real:

@anishmoonka It’s happening 🤣

Your dog could soon get a daily pill that slows aging. 1,300 dogs are already testing it across 70 vet clinics, and it just passed its second FDA safety review in January. The drug is LOY-002. A San Francisco startup called Loyal makes it. Celine Halioua started the company in 2019 when she was 24. They have raised $250 million so far, including $100 million in February from Baillie Gifford, the same firm that bet early on Tesla and Amazon. The simplest way to explain what it does: if you put a dog on a strict diet where it eats way less food, that dog tends to live about two years longer. Cancer and arthritis both show up later. The body just ages more slowly. LOY-002 gives the dog those exact benefits without actually eating less. The dog keeps its appetite and its weight; it just ages more slowly. The trial is called STAY. Half the dogs get a beef-flavored pill every day, and the other half get a fake version that looks and tastes the same. The FDA reviewed safety data from over 400 dogs. Zero serious side effects, even at five times the normal dose. Loyal has now cleared two of three hurdles for conditional approval, which basically means they could start selling the drug while the full trial keeps going. The last piece, manufacturing, goes to the FDA in 2027. One thing the tweet gets a bit wrong: the pill is for senior dogs aged 10 and older, at least 14 pounds. And Loyal is being careful about the "years" claim. Right now, they are saying at least one extra year of healthy life. They want to prove more, but the trial needs to finish first. If LOY-002 gets approved, it would be the first drug the FDA has ever cleared to slow aging in any species, human or animal. Loyal also has two more drugs coming for big breeds like Great Danes and Rottweilers. Those dogs die younger partly because of a hormone called IGF-1, which makes them grow fast but also wears their bodies out quicker. And a separate project backed by a $7 million grant from the NIH (the agency that funds medical research) is testing a human organ transplant drug called rapamycin in 580 dogs to see if it slows aging, too. The global pet care market hit $261 billion last year. A once-a-day pill that gives your dog even one extra healthy year could easily become one of the best-selling veterinary drugs on the planet.

@steipete We got him

I'm working on character evals and noticed that Claude would constantly pick itself as #1, so I removed the model names from the judge and changed things.

@AlexFinn @NotSoEasyMoney What about local models 😅

@NotSoEasyMoney Just pay for opus. Go into debt if you have to. Nothing else comes close to OpenClaw

So… What are people using for their open claw now? Or are you just paying for the usage? And if so, how much we racking up in costs there

@steipete @sami0x5 Now I’m nervous to reply to you, what if it’s wrong 😅

@sami0x5 nah, please keep reply bots away from X. My claw detects and blocks these, on some days it's hundreds of accounts.

I'm wondering, does @steipete use OpenClaw to replay all the posts? I think he hasn't missed a single post to replay.

@davidasinclair How close are we?

We are closer to controlling aging than most people realize

@BartlomiejRW @davidasinclair Year 1 - really rich Year 5 - everyone not in the 3rd world can have it if they want it

@davidasinclair Superb!!! But will this discovery be applicable for general public? How rich will have to man be to acquire your treatment

Age is not fixed.
It’s dynamic. This is one of the most remarkable discoveries of the century

@steipete @xlr8harder I do similarly - Proceed until each step of (project x) is complete or you’re blocked - with each completed step also kick off the next.

@xlr8harder "take your time, don't stop till X" (x=done or condition)

I've been leaning more on gpt-5.4 in codex than opus in claude code lately. I have come to trust gpt-5.4-high to be more organized and complete in its approach. but how do i get gpt-5.4 to actually keep working without constantly stopping for reassurance? who has tricks here

@ScottPresler @LeaderJohnThune It’s time to replace the Uniparty, it’ll need to be more than just Texas - but we welcome you.

This is day 94 of asking @LeaderJohnThune to pass the SAVE America Act. If Senate Majority Leader Thune doesn’t pass the SAVE America Act, then I’m coming to Texas.

@steipete I don’t know, perhaps they should spin up Openclaw to help filter more of the work?

Prediction: This is gonna kill some oss projects. "On the kernel security list we've seen a huge bump of reports. We were between 2 and 3 per week maybe two years ago, then reached probably 10 a week over the last year with the only difference being only AI slop, and now since the beginning of the year we're around 5-10 per day depending on the days (fridays and tuesdays seem the worst). Now most of these reports are correct, to the point that we had to bring in more maintainers to help us." lwn.net/Articles/10656…

@gfodor Relevant

Finally listened to the Dario interview and it blows my mind how his entire worldview around AI seems to be predicated on an assumption nobody is going to YOLO upload a tarball of frontier model weights to the Internet.

@hosimaki You’ll fit right in

Xの自動翻訳 普通に機能してるな… 英語のポストが勝手に翻訳されて流れてきてる ということはこっちの発言も勝手に流れてる…ってこと！？ おっぱい！！！！！

@AiPinfu2003 Tell me more

アメリカ人は日本人のタブーも知っておいたほうがいい。 政治と野球と宗教とガンダムの話はあまりしないほうがいい。 特にガンダムは気をつけろ。 原理主義者がいる。

@yoyonofukuoka I mean, I could read it Now tell us some secrets

日本語投稿が、自動で英語翻訳されてると聞いたけど、それは本当ですか？ 本当ならメチャクチャ嬉しい。

@ArtemisConsort Banger indeed

The average quality of the Japanese posts now on my timeline is about 2 standard deviations higher than the non-Japanese posts. Possibly the biggest product improvement I’ve yet experienced on this app. Great stuff.

@DataRepublican What would it take to replace Thune with, say @BasedMikeLee

Clint is an insider. Senator Thune betrayed the entire institution of the United States Senate.

@nikitabier People don’t know what they want You must teach them.

Every time we do a user survey. What would make X better for you? Normal Person: > Maybe a podcast feature? Guy who reposted 370 videos from TikTok using Scheduled Posts, has never opened the app, and has a bot writing replies: > *Foaming from mouth* > Gib…more…money….

@steipete @kevinrose Their logo should be a blue pill

@kevinrose try codex, lasts way longer.

well, I just maxed out my claude max plan -- can't use it again until Tuesday, what does one do?

@steipete @_egzim @discord who do we call?

@Nathanone @_egzim That's gonna be harder I fear, but happy to get referrals!

Sooo I got MS Teams, I got Telegram, and I'm just onboarding @_egzim to make our Slack channel integration amazing! Claw level ↑🦞