Nick Bailey

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Nick Bailey

Nick Bailey

@NickBailey596

Research Fellow @SchoolOfBiology @KosiolG. Interested in evolution, genetics, statistics, computer science, and their intersection (“bioinformatics”)

เข้าร่วม Ekim 2019
285 กำลังติดตาม155 ผู้ติดตาม
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Nick Bailey
Nick Bailey@NickBailey596·
Excited to announce my first resource publication “Correcting for Bias in Estimates of Watterson’s theta and Tajima's D From Missing Data in Next-Generation Sequencing” out now in Molecular Ecology Resources! Article linked below in short thread 👇
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Nick Bailey
Nick Bailey@NickBailey596·
@nomad421 "largely irrational supernatural claims that have failed, over millennial, to yield reproducible evidence." Chaning to decades or centuries instead of millennia, seems like an apt description of numerous fields of science...
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𝕐@nomad421·
Pretty much no serious atheist I know of criticizes God or Satan. Rather, they criticize the idea of adopting and centring one's life and beliefs on largely irrational supernatural claims that have failed, over millennial, to yield reproducible evidence.
Dr STAN@realBigStanH

Good question

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Nick Bailey
Nick Bailey@NickBailey596·
Fisher pushed for financial incentives (not sterilization) along these lines but even he realised it was extremely idealistic to think such policy would remain popular long enough. If we started when he suggested it we’d only have… about 995 generations left to go!
Lyman Stone 石來民 🦬🦬🦬@lymanstoneky

Proving the point. "If we just sterilize the criminals for 30,000 years continuously we will eventually make criminality extinct!" Yes, a eugenics program lasting longer than an entire interglacial period could have some effects. x.com/RokoMijic/stat…

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Nick Bailey
Nick Bailey@NickBailey596·
@SteveStuWill What does it mean to say someone is the "Einstein of evolutionary biology"?
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Steve Stewart-Williams
Steve Stewart-Williams@SteveStuWill·
RIP Robert Trivers - the Einstein of evolutionary biology and one the greatest thinkers of our age. Among other things, Trivers came up with parental investment theory, reciprocal altruism theory, and parent-offspring conflict theory.
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Gurwinder
Gurwinder@G_S_Bhogal·
"No man is clever enough to know all the evil he does." —François de La Rochefoucauld
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Nick Bailey
Nick Bailey@NickBailey596·
@chuckdis25 @NeilShenvi STEM should ideally also teach those. In particular, I think probability theory and statistics help people reason about the world much better.
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Charles Shin
Charles Shin@chuckdis25·
@NeilShenvi Another way of looking at it: classical education teaches students how to read, reason, and communicate, all of which are fundamental to advancing in STEM, or any other field.
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Neil Shenvi
Neil Shenvi@NeilShenvi·
One legitimate criticism of "classical education" is that it can undervalue the importance of STEM because it developed long before the explosion of scientific and mathematical knowledge in the 19th-20th centuries. That said, there's a simple fix: teach more STEM!
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Nick Bailey
Nick Bailey@NickBailey596·
@nntaleb @HarbTom @grok Explain that LLMs (“AI”) don’t have “logical consistency” except as an accidental byproduct of probabilistic word-guessing. Oh wait, I just explained it myself without an LLM, nevermind.
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Nassim Nicholas Taleb
Nassim Nicholas Taleb@nntaleb·
Because of its logical consistency, AI helps against misrepresentations & smear campaigns. Here it catches bullshit artists like Tom Harb @HarbTom trying to smear yours truly & propagating straw man versions of my political ideas.
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Nassim Nicholas Taleb@nntaleb

@grok @HarbTom Grok, you are good. Very good.

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Nick Bailey
Nick Bailey@NickBailey596·
@nntaleb Fig. 1 implies equal relationship between all Xs, which may fit null exp. of f4 but interpretation assumes rooted caterpillar bifurcating trees. Topology is relevant to know if mut shared by X2 and X4 is ILS or admixture. Also are Xs genotypes instead of allele freqs?
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Nick Bailey
Nick Bailey@NickBailey596·
I've imaginatively wondered if similar tests could apply to evolutionary DNA/protein LMs. For example, could a model trained on coronavirus genomes/proteomes prior to 2019 predict SARS-CoV-2? @eryney_ok @yun_s_song @pdhsu @ebetica
Rohan Paul@rohanpaul_ai

Demis Hassabis’s “Einstein test” for defining AGI: Train a model on all human knowledge but cut it off at 1911, then see if it can independently discover general relativity (as Einstein did by 1915); if yes, it’s AGI.

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Nick Bailey
Nick Bailey@NickBailey596·
@eryney_ok @yun_s_song @pdhsu @ebetica I was thinking of a notable example of a pathogen worth predicting, but specifics should vary. I guess for the COVID spike a phylo AI model wouldn’t readily account for recombination, and I suppose COVID origins are disputed… then what to do with that info socially who knows
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Eryney
Eryney@eryney_ok·
Hm, with COVID was the issue more so that the spike structure was allowing for a novel mechanism, or just that it was unexpected? My understanding is that AF1 probably would have been able to predict structure, but AF3/RF3 wouldn't be able to solve the problem of being caught flat footed when it comes to community monitoring!
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Yun S. Song
Yun S. Song@yun_s_song·
Our work unifies two historically disparate fields: phylogenetics & protein language models (pLMs). Classical phylogenetic models provide a rigorous treatment of time and quantify the effects of mutation & selection, but assume site independence & require aligned sequences. 2/n
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Alex Strudwick Young
Alex Strudwick Young@AlexTISYoung·
Which AI pro subscription should I get for advanced technical/scientific research?
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Nick Bailey
Nick Bailey@NickBailey596·
@WKCosmo Yes and the NSF is one such organization though you evidently have no qualms getting money from them.
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Will Kinney
Will Kinney@WKCosmo·
Something that should be discussed more is just how many sketchy organizations there are who cater to academics chasing fame. Templeton, TED, IAI. It's not just Edge. There's a reason I have never applied for Templeton money, and why I have turned down offers to write for IAI.
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Nick Bailey
Nick Bailey@NickBailey596·
@infobeautiful @AndrejSpiridon4 These are all based on averages, worth noting since it’s sold explicitly as when “you” peak, which will inevitably fool some people into thinking they personally missed the boat or need to wait on some of these.
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Nick Bailey
Nick Bailey@NickBailey596·
@F_Sid_Dougan Nice clear article! I'm skeptical of the insinuation that math models can demonstrate empirical impossibility. I don't know the PBS model well but I gather its fitness optimising, excluding drift, which makes crossing fitness valleys always have non-zero probability.
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Francis (Sid) Dougan
Francis (Sid) Dougan@F_Sid_Dougan·
🧵 1/15 - "THERE ARE ONLY TWO SEXES AND THERE CAN NEVER BE MORE" - my publication in Archives of Sexual Behavior. Thread with link and very brief summaries of the main points I cover in the paper...
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Nick Bailey
Nick Bailey@NickBailey596·
@Satyaki_R @nntaleb @seagertp If the product status is immaterial why isn't the book given away for free? Did Topol and the publisher work for free? No. For better or worse, rigorous scholarship is as monetizable as anything else. Also, knowledge doesn't spread by magic, people have to bring attention to it.
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Satyaki Roy
Satyaki Roy@Satyaki_R·
@NickBailey596 @nntaleb @seagertp It's not incoherent to you. You are incoherent. Whether the book is a product or not is immaterial cause it's rigorous scholarship. A book (or product) which is not rigorous scholarship will be subject to the filter of books such as these. 'research fellow'
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Thomas P Seager, PhD
Thomas P Seager, PhD@seagertp·
Eric Topol: "If someone is selling something, they have no credibility. Zero." Also Eric Topol: "Buy my 'Super Ageing' book, which I have stacked in the background as product placement for this interview."
Acyn@Acyn

Topol: The same thing occurs with all these wellness influencers—the latest being Peter Attia. There are hundreds and hundreds of these so-called longevity hackers. One cardinal rule I have is this: if somebody is selling something, they have no credibility. Zero.

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Nick Bailey
Nick Bailey@NickBailey596·
@nntaleb @seagertp This is incoherent to me. The book is being sold as a product by a non-academic publisher for a profit. Also, I don't even know what the term "product neutral" means and searching the internet is not giving me any clues.
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ค้นพบ

@nomad421 @SteveStuWill @G_S_Bhogal @chuckdis25 @NeilShenvi @nntaleb @HarbTom @grok