Stefan Pfeffer

82 posts

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Stefan Pfeffer

Stefan Pfeffer

@PfefferCryoLab

Cryo-electron microscopy, structural biology of molecular machines, ribosome-associated processes

Heidelberg, Germany เข้าร่วม Ekim 2020
118 กำลังติดตาม553 ผู้ติดตาม
Stefan Pfeffer
Stefan Pfeffer@PfefferCryoLab·
Nearly two decades after augmin's discovery in Drosophila, we have reconstituted the microtubule-binding region of the Drosophila augmin complex on microtubules and demonstrate the conserved mechanism by which the augmin subunit HAUS6 orients augmin for microtubule branching.
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Stefan Pfeffer
Stefan Pfeffer@PfefferCryoLab·
Out just now at @NatureComms: using cryo-EM and cryo-electron tomography, we provide evidence that structurally heterogeneous ribosomes can cooperate in protein synthesis in bacterial cells: nature.com/articles/s4146…
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Stefan Pfeffer รีทวีตแล้ว
Sergey Melnikov
Sergey Melnikov@SergeyVMelniko1·
1/2 Here we unexpectedly find that protein S20/L26—identified at the dawn of ribosome research but then deemed a ribosome isolation artifact—is indeed a genuine component of the large ribosomal subunit. More on this ribosome content variation: nature.com/articles/s4146…
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Stefan Pfeffer
Stefan Pfeffer@PfefferCryoLab·
A great collaboration with the Schiebel Lab @Zmbhh @UniHeidelberg and the Gruss Lab @UniBonn. Congratulations to all authors, in particular the shared first authors Qi Gao, Florian Hofer, Bram Vermeulen @BramV98 and Sebastian Filbeck!
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Stefan Pfeffer
Stefan Pfeffer@PfefferCryoLab·
Out just now at @NatureComms and a great start into the New Year: we reveal how yeast cytoplasmic γ-TuRC is assembled and activated by dimeric CM1 motifs of the receptor protein Spc72 and how the microtubule polymerase Stu2 binds to promote MT assembly. nature.com/articles/s4146…
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Stefan Pfeffer รีทวีตแล้ว
ZMBH - Center for Molecular Biology Heidelberg
ZMBH - Center for Molecular Biology Heidelberg@ZmbhH·
Congratulations to Martin Würtz, who yesterday received the Nikon Young Scientist Award 2024 for excellent research in cell biology awarded by the German Society for Cell Biology.
ZMBH - Center for Molecular Biology Heidelberg tweet media
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Stefan Pfeffer
Stefan Pfeffer@PfefferCryoLab·
We still have open PhD positions here in our cryo-EM group @ZmbhH @UniHeidelberg. Please apply via the Heidelberg Biosciences International Graduate School or directly send us your application documents. hbigs.uni-heidelberg.de
Stefan Pfeffer@PfefferCryoLab

We have two open PhD positions to explore structures of ribosomes and gamma-tubulin complexes using cryo-EM approaches here in our group @ZmbhH @UniHeidelberg. Please apply via the Heidelberg Biosciences International Graduate School @HBIGS_HD: hbigs.uni-heidelberg.de

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Stefan Pfeffer
Stefan Pfeffer@PfefferCryoLab·
Out just now @embojournal: our cryo-EM structure of the native RanGTP-induced γ-TuRC-capped microtubule, revealing a surprisingly asymmetric minus end architecture with direct implications for microtubule regulation and modulation during spindle assembly. embopress.org/doi/full/10.10…
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ค้นพบ

@martin_wuertz @ZmbhH @FabioLolicato @EustermannLab @embl @NatureComms @SergeyVMelniko1 @UniofNewcastle