B. Fadi Marayati, Ph.D.

The CRISPR family’s most versatile member has made its medical debut: a cutting-edge gene-editing technique known as prime editing has been used to treat a person for the first time go.nature.com/4kqr3RK

Nature research paper: Adipose tissue retains an epigenetic memory of obesity after weight loss go.nature.com/4eJizC8

Today we report in @NatureBiotech a system for the laboratory evolution of engineered virus-like particles (eVLPs) that enables the discovery of eVLP variants with desired properties, including improved production and delivery potency. 1/13 PDF: drive.google.com/file/d/1E6Nr86…

7 Men. All science Nobels this year went to men. Well done men.

Nobel Prize in Physiology or Medicine: Biology Nobel Prize in Chemistry: Biology Nobel Prize in Physics: Sounds like Biology #NobelPrize

Doing good science is 90% finding a science buddy to constantly talk to about the project.

Excited to share our latest work developing DART transgenic mice and using them to profile m6A in single cells of the mouse brain. A fantastic study led by Matt Tegowski with contributions from @TheHolleyLab nature.com/articles/s4159…

The September issue is live nature.com/nbt/volumes/42… Our cover shows cellular mRNA modified by m⁶A, which is depicted as a gemstone. Marayati et al. develop GEMS, a genetically encoded m⁶A sensor that can report changes in m⁶A in living cells go.nature.com/41N2h67

We are excited to have our m6A sensor technology featured on the cover of the latest issue of Nature Biotechnology. Congratulations again to first author @RNAloops and @TheHornerLab and @TheHolleyLab for their great contributions! nature.com/nbt/volumes/42…

Nanopore-based native RNA sequencing of human transcriptomes reveals the complexity of mRNA modifications and crosstalk between RNA ... biorxiv.org/cgi/content/sh… #biorxiv_genomic

A dual sgRNA library and dCas9-effector protein that will enable new forms of CRISPRi-based screening in mammalian cells. elifesciences.org/articles/81856…

Check out my dear colleague and @Duke_CMB director Dr. Mike Boyce (@BoyceLab) @DukeMedSchool Spotlight, discussing all his contribution to DEI programs at Duke and nationwide through @ASCBiology! Thanks for all you do, Mike! medschool.duke.edu/blog/edi-spotl…

Scientists have developed an antibiotic that kills pathogenic Gram-negative bacteria without impairing the gut microbiome go.nature.com/3X4OTdg

@NobelPrize winner Thomas Cech's recent essay in the @nytimes highlights #RNA as the molecule set to redefine the future of science. While DNA has historically dominated research, RNA is emerging as a cornerstone for new scientific breakthroughs. In the essay, Cech recounts his discovery of RNA's catalytic power, emphasizing its roles beyond genetic information storage, such as enzyme activity and chromosome protection. RNA's versatility has led to innovative therapies, including #mRNA vaccines and treatments for spinal muscular atrophy and cancers. Cech sums up the opportunity by saying, "The age of RNA is just getting started." 🔗 Read the full essay here: nytimes.com/2024/05/29/opi… We are honored to have Thomas Cech as an External Advisor at the Science Philanthropy Alliance, where he continues to inspire and guide our mission to advance scientific discovery through visionary philanthropy. #science #philanthropy

Special Issue of RNA presents the past, present, and future of epitranscriptomics research with a focus on mRNA. It includes perspectives from experts in the field, with the goal of encouraging discussions that will further advance this area of research bit.ly/4bSEfur

“It’s really just scratching the surface. It’s showing that it’s possible to design these complex systems with machine-learning models” go.nature.com/4bezg6Y

The first prime editing clinical trial has been cleared by @US_FDA to begin: prime editing of HSCs to treat chronic granulomatous disease (CGD). Congratulations to @PrimeMedicine on achieving this key milestone only 4.5 years after we published the first prime editing paper.

🔬 Condensates: When fixation creates fiction A chemical regularly used to image cells can dramatically alter the way cellular compartments called condensates look under the microscope. 12/13 elifesciences.org/articles/85671…

very cool study! Somehow the story feels like it's got m6A written all over it. Malat1 running the show again!

Best acknowledgment section ever 😂