Rajiv Trehan

@ShadinGhabra_MD @NatureComms Thank you Shadin! It was wonderful to collaborate on this and future projects!

@RTMedEngineer @NatureComms Congratulations on your success! I look forward to your very bright career ahead!! @RTMedEngineer rising star 🌟

1/10 🚨 Excited to share our study in @NatureComms where we reveal how tumor-associated macrophage transdifferentiation predicts and promotes liver metastasis—a key mechanism driving immunotherapy resistance. 🔗 nature.com/articles/s4146…

10/10 Thank you to @dkstrepay @ShadinGhabra_MD @MartinAArhin @BenmebarekMr @TimGreten #CancerResearch #LiverMetastasis #ImmunoOncology #TumorImmunology @theNCI @NIH

9/10 👉 This opens exciting opportunities: – Use the macrophage signature to stratify patients at high risk of liver mets – Target transdifferentiation pathways (SPP1, TGF-β, IL-6) to prevent liver colonization

8/10 Our work suggests that the liver isn’t just a passive site for metastasis—it’s actively preconditioned by macrophage remodeling even before tumor cells arrive.

2/10 Liver metastases are a major clinical challenge across many cancers. Despite abundant tumor-reactive T cells in the liver, these metastases often resist immune checkpoint blockade. Why?

Excited to share our study on the treatment effect and underlying mechanism using a triple therapy of VEGF+PDL1+CTLA4 blockade in CCA, published today in @ImmunityCP👨‍🔬🥳 Article: authors.elsevier.com/c/1km4D3qNrU-h… A brief summary of the exciting science from @TimGreten lab below: (1/6)

Innovation grant to understand resistance to chemo immunotherapy in CCA…dream team! ⁦@theNCI⁩ ⁦@curecc⁩ ⁦@

@jamaldonadoMD Congrats!

It’s finally here! Friday can’t come soon enough! #Match2024 #IMProud

@MaevePascoe @byrnebabybyrne3 @NIHBrainTumor Congrats!

So happy that our first co-first author publication together is out in the world! @byrnebabybyrne3 your passion for AYA patients is contagious, and so glad we can shed light on the challenges of CNS cancer research in this population @NIHBrainTumor pubmed.ncbi.nlm.nih.gov/38250563/

In the latest issue! Tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive margin dlvr.it/StyYBW

Couldn't be more grateful to be part of this fantastic team effort with many friends and collaborators @matthias_bruhns @LichunMa @mrevsine @BenmebarekMr @DrHeinrichB @varuny_tunes @bengreen_MD @KCBSkope @RTMedEngineer @ruchinskas @mkss49 @XinWang77 and many more. (8/11)

🥳🥳🥳Couldn't be happier to see our study on mucosal-associated invariant T (MAIT) cells in HCC published today in @CellCellPress. Article: authors.elsevier.com/c/1hbwdL7PXmdKm Brief summary of this exciting collaborative work between @TimGreten lab and @claassenlab below (1/11):