Talking CRISPR

@NatureMedicine @Jonathanthdk @smoineau @stokholm_jakob @JPI_HDHL @novonordiskfond @COPSAC_com Huge congrats to @cristinalero for driving this one home!

Phages in babies protect kids from disease half a decade in the future! Full text on @NatureMedicine : rdcu.be/dtGTc #phage #CRISPR #virome @Jonathanthdk @smoineau @stokholm_jakob @JPI_HDHL @novonordiskfond @COPSAC_com

@smoineau 8 years from conception to paper. Huge international collaboration. Multiple grants. What a journey! @jpihdhl @novonordiskfond @RegionH @INRAE_Intl @COPSAC_com @UCPH_Research #SandrisLab

We wrote a grant in 2015, got funded in 2016 (JPIHDHL/Europe, DAHES/Denmark, INRAE/France, #CIHR/Canada), then a team of great scientists elevated this initiative to a new high. Extra funding led to this👇Huge congrats to the EarlyVir Team! #phage #COPSAC nature.com/articles/s4159…

The baby #phage #asthma story is on the front page of politiken.dk now

Phages in babies protect against future disease! Check out our latest paper in @NatureMedicine nature.com/articles/s4159… @COPSAC_com

@simroux_virus Nice!! Is the new GTDB-based db downloaded by default with "iphop download --db_dir path_to_iPHoP_db", or do you need to do something else to get that? Is it the one called "iPHoP_db_Aug23_rw"? Thanks, Simon 💙

!! Release update !! If you uses iPHoP for phage host prediction: we just released a new version (1.3.3), alongside an updated host database now based on GTDB r214. Updated code and database available via conda / Docker. Please report any issues to bitbucket.org/srouxjgi/iphop…

Alright, admitted, I was intimidated by twitter's name change, and haven't been online before now. But since then, this happened!!! Big congrats to @SarahCamara94 #dav604 and @rafapinilla92 uncovering these unbelievable RNA based anti-#CRISPR s

Such a pleasure talking with @JacquesHughes about our findings. Big thanks to the @NaturePodcast team for having me! Tune in to the episode to hear our conversation🦠🎙️ nature.com/articles/d4158…

Dr. Evelien Adriaenssens wrote this beautiful opinion piece about our recent baby virus study. She is the chair of the bacteriophage subcommittee within the ICTV, so her opinion matters. And I'm humbled to say the least. @COPSAC_com @JPI_HDHL #phage

MindBlow on @VsauceTwo is featuring our infant gut virome story (skip to 0:39) 🤓😃😎 youtu.be/sxi0-Y_RWsU?t=… #virome #omics #YouTube @JPI_HDHL @COPSAC_com @NatureMicrobiol @novonordiskfond

Now also on @WebMD: webmd.com/children/news/…

Nice coverage on our infant virome story! @COPSAC_com @JPI_HDHL @washingtonpost @novonordiskfond @NatureMicrobiol washingtonpost.com/health/2023/04…

New database of 10.000 infant gut phages to map your baby reads against: copsac.com/earlyvir/f1y/f… copsac.com/earlyvir/f1y/t… copsac.com/earlyvir/f1y/a… @JPI_HDHL @COPSAC_com @novonordiskfond #omics #phage #virome

Looks like phage diversity is higher in babies than adults. Why? Check out the story behind the paper. It's a four-minute read. microbiologycommunity.nature.com/posts/infant-g… @COPSAC_com @JPI_HDHL @NatureMicrobiol #phage #CRISPR #virome @cristinalero @smoineau @stokholm_jakob @GormAnders @microUCPH

We found hundreds of viral families in baby diapers. Everything we found is online (copsac.com/earlyvir/f1y/f…). This project started all the way back in 2016. So excited that it's finally out! @COPSAC_com @JPI_HDHL #OpenScience #phage #CRISPR #virome #metagenome

@TCrispr lays out his brilliant paper on phages in childrens gut. I remember once thinking "Wow, we identified a handful of new viral families!". Shiraz and the rest of this group just found +100 new ones 🤯 Check out the brilliant online overview 👇 tiny.cc/aq76vz

The guts of healthy infants are alive with viral diversity @COPSAC_com @NatureMicrobiol nature.com/articles/s4156… #phage #CRISPR #microbiome #virus

1/n Excited to share a story on prokaryotic Argonautes (pAgos)!! 🎉 Here, we describe a short pAgo that mediates robust antiviral protection!🛡️ But how!? 🧵👇 biorxiv.org/content/10.110…

Another defence system, guys: biorxiv.org/content/10.110… The prokaryotic argonaute recognises viruses using a guide RNA, then activates a transmembrane protein to depolarise the membrain and commit suicide. #antiviral #antiphage #archaea #CRISPR

Very excited to see our story online in @NAR_Open!🎉 We found plasmids in nature carry a fascinating diversity of CRISPR-Cas🌈🤯 We characterized their abundance, diversity, distribution & investigated their CRISPR contents to infer their function(s)!! academic.oup.com/nar/advance-ar…