Kurtis Edwards

@lvolpic Also seems like an easy and simple way to make science actually accessible to the public.

NIH is requiring all publications be open access next year. Should a "lay" audience summary of the research be included with each publication? I personally can't understand some articles because they are written with lingo (ephys and biophysics folks I'm talking to you)

😭🤣

The irony

@peter_bonfield @_LucyPetagine @LifeSciWestmin @SLSPhD_UoW Thank you, Peter!

Cheers to becoming a Dr! What a ride the last few years have been but couldn’t have wished for a better friend and colleague 🫶🏼 @_kurtisedwards @LifeSciWestmin @SLSPhD_UoW

Immune system one pager

First research symposium for the Health Data Sciences Research group today ‘Big data and Beyond’. Huge thanks to our fantastic speakers from the group, the @RCOptimalHealth, plus PhD candidates, Research Fellows and MSc students from across @LifeSciWestmin. A brilliant day.

Our newest paper is now published! Ketosis Suppression and Ageing (KetoSAge) Part 2: The Effect of Suppressing Ketosis on Biomarkers Associated with Ageing, HOMA-IR, Leptin, Osteocalcin, and GLP-1, in Healthy Females Metabolic dysfunctions are among the best documented hallmarks of ageing. Cardiovascular disease, Alzheimer’s disease, cancer, type 2 diabetes mellitus, metabolic-dysfunction-associated steatosis liver disease, and fragility fractures are diseases of hyperinsulinaemia that reduce life and healthspan.  We studied the effect of suppressing ketosis in 10 lean (BMI 20.5 ± 1.4), metabolically healthy, pre-menopausal women (age 32.3 ± 8.9 years) maintaining nutritional ketosis (NK) for an average of 3.9 years (± 2.3) who underwent three 21-day phases: nutritional ketosis (NK; P1), suppressed ketosis (SuK; P2), and returned to NK (P3).  Results: Ketosis suppression significantly increased: ➡️ insulin 1.83-fold (p = 0.0006) 💥 ➡️ glucose 1.17-fold (p = 0.0088)💥 ➡️ homeostasis model assessment for insulin resistance (HOMA-IR) 2.13-fold (p = 0.0008)💥 ➡️ leptin 3.35-fold (p = 0.0010) 💥 ➡️ total osteocalcin 1.63-fold (p = 0.0138) 💥 ➡️ uncarboxylated osteocalcin, 1.98-fold (p = 0.0417) 💥 Suppressing ketosis significantly decreased: ➡️ beta-hydroxybutyrate, 13.50-fold (p = 0.0012) and 💥 ➡️ glucagon-like peptide-1 (GLP-1), 2.40-fold (p = 0.0209). 💥 ☀️Sustained NK showed no adverse health effects and may mitigate hyperinsulinemia. ☀️All biomarkers returned to basal P1 levels after removing the intervention for SuK, indicating that metabolic flexibility was maintained with long-term euketonaemia. Awesome co-authors @Yvoni_Kyr @AdrianSotoMota @kenbrookler @Brads_science @_kurtisedwards @_LucyPetagine mdpi.com/2227-9059/12/7…

So much time and money is wasted trying to replicate experiments and reproduce data. Looks like @brieflybio will be a scientific GitHub for wet lab work. Imagine starting your PhD with access to this kind of repository!

@JSheltzer Treat a load of patient-derived tumoroids with the drugs. Take samples from patients with both good and poor prognostic profiles. Compare efficacy between risk groups.

A genie gives you two new cancer drugs. One drug will receive FDA approval while the other will fail in clinical testing. The genie challenges you to identify the drug that will succeed in the future. You can perform one experiment on each drug - what experiment do you choose?

Accurate 😭😭😭

Interesting that NICE, in a rather old doc, refer to Ibrutinib as a mAb... Which it is not. nice.org.uk/guidance/ta429…

This is a neat concept. Sometimes you have great ideas but you need great collaborators to execute them.

Really cool

Lymphoma Classification Any suggestions/critiques? @AaronGoodman33 @nihardesai7 @dgermain21 @Eddie_Cliff @CharlesMilrod

CAR-T for $30,000! nature.com/articles/d4158…

Was great to attend the UK CLL Forum’s Annual Scientific Day! Tons of great data addressing the BCR. Fantastic talks from the pioneers, Prof Stevenson and Prof Chiorazzi.

@peter_bonfield @pollyhayes @NPorakishvili @emanuela_volpi @LifeSciWestmin Thank you! 😁

Congratulations to @_kurtisedwards Edwards on successfully defending his PhD thesis today 🎉 and to his supervisory team @NPorakishvili, @emanuela_volpi, Amit Nathwani and Peter Lydyard 🎉 Thanks to Examiners John Murphy and Prof. Chris Pepper!! @LifeSciWestmin @peter_bonfield

I'm really happy with the paragraph I just wrote. I'll miss it when I change my mind in 5 minutes and delete it.

@pollyhayes @LifeSciWestmin @claire76 @Brads_science @drdanbrayson @adiposesite It was great to meet the new cohort of researchers! Looking forward to seeing you all in the SLS labs! 🥼 🧪

Welcome to our new @LifeSciWestmin Doctoral Researchers! Two afternoons of Induction Workshops done ✔️ With thanks to @claire76 @Brads_science @drdanbrayson @adiposesite Julia Hendricks @_kurtisedwards

Celebrations for our lab today with @I_mitochondria's first experimental paper cebrated with the customary mug, and overdue recognition of Jacqueline's awesomeness and recent successes. @Yvoni_Kyr @_kurtisedwards @_LucyPetagine & noemi helping celebrate