Becca Deaton
10 posts

Becca Deaton
@beccadeaton
Scientist, wife, mom of 3 boys. Never a dull moment.

A mouse model of #Atherosclerosis (SR-BI∆CT/∆CT;Ldlr−/− + #WesternDiet) mimics late-stage events of human disease😎 👉75% #MyocardialInfarction 👉38% #Stroke 👉31% #PlaqueRupture Similar lipid & liver enzyme profile to Ldlr-/-🐭except for 45% low HDL-C & body weight Does this mouse have distinct SMC lineage trajectories from Ldlr-/-🐭? 😁 +Therapeutic effects of AZM198, myeloperoxidase inhibitor AZM198-> ⏫Sox9+Col2a1+ SMC subset (~5-fold!😮Re-thinking the role of the osteochondrogenic SMCs?) ⏫Contractile SMC subset ⏬Klf4+Egr1+ modulated SMC subset @lab_owens @CircAHA 2024 ahajournals.org/doi/abs/10.116…

A new autosomal Myh11-CreERT2 mouse allows inclusion of both sexes in SMC lineage-tracing and gene-knockout mouse studies @gamze_b_bulut @Anita_Salamon_ ahajrnls.org/3FzJjFs





A new autosomal Myh11-CreERT2 mouse allows inclusion of both sexes in SMC lineage-tracing and gene-knockout mouse studies @gamze_b_bulut @Anita_Salamon_ ahajrnls.org/3FzJjFs


A new autosomal Myh11-CreERT2 mouse allows inclusion of both sexes in SMC lineage-tracing and gene-knockout mouse studies @gamze_b_bulut @Anita_Salamon_ ahajrnls.org/3FzJjFs





