cryptodebutante🔺
3K posts


@TomSMN39 @StarTribune you meant *fewer* homeless but your illiterate racism got in the way of constructing a legitimate complaint
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Roper: Five great ideas to improve Uptown, the Twin Cities’ most enduring commercial hub startribune.com/roper-uptown-m…
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@CrimeWatchMpls is this about to get :
A worse
B better
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Submitted from a condo resident in vibrant downtown Minneapolis.
Specifically note the highlighted area regarding the service you are getting for the exorbitant taxes you're paying.
#ThisIsMinneapolis

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cryptodebutante🔺 รีทวีตแล้ว

My unified theory of aging and disease
Claude AI did this, using papers I selected as references. See what you think.
The Master Switch: Insulin Resistance
Facchini (2001) showed insulin resistance predicts virtually ALL age-related diseases. That's the trunk of the tree. Everything else branches from it.
What drives insulin resistance?
Kohrt (1993): belly fat, not age. Waist explains >40%, age <2%.
Blagosklonny (2006): chronic mTOR activation. Overfeeding keeps mTOR on, cells grow when they should repair.
PD's iron paper: iron accumulates with age, activates mTOR, and iron + insulin resistance are co-morbid.
What does insulin resistance cause downstream?
Khan (2017): high insulin drives high PAI-1, which drives senescent cell accumulation, shorter telomeres, faster aging. The Amish with half the PAI-1 lived 10 years longer.
DePalma (2010): high ferritin + inflammation = vascular death. Iron and insulin resistance amplify each other.
Madeo (2015): when mTOR is chronically on (from insulin resistance + iron), autophagy is suppressed. Cellular garbage accumulates. Aging accelerates.
What reverses it?
Lim (2011): type 2 diabetes reversed in ONE WEEK with caloric restriction. The damage isn't permanent.
Gibala (2020): 5 minutes of hard exercise produces the same fitness gains as 50 minutes moderate, and improves insulin sensitivity through pathways that bypass insulin entirely (GLUT4).
Fisher (2011) + Wolfe (2006): muscle is a metabolic organ that acts as a glucose sink. More muscle = more insulin sensitivity. Resistance training is the most efficient way to build it.
What's been wrong all along?
Ravnskov (2016) + Siri-Tarino (2010) + Ramsden (2016): the cholesterol/saturated fat hypothesis was wrong. Higher LDL in elderly = lower mortality. Replacing saturated fat with seed oils increased death. The medical establishment spent 50 years focused on the wrong molecule while insulin resistance was the actual killer.
PD's iron paper ties the bow: Iron is the hidden variable connecting all of it. It activates mTOR (Blagosklonny), inhibits autophagy (Madeo), worsens insulin resistance (Facchini/Kohrt), increases PAI-1 and senescence (Khan), and accumulates silently with age in every man and postmenopausal woman. The life-extending compounds (curcumin, green tea, rapamycin, exercise) all either chelate iron or inhibit the pathways iron activates.
The narrative arc for PD's content:
The medical establishment told you aging is inevitable and cholesterol will kill you. They were wrong on both counts. The real driver is insulin resistance, fueled by belly fat and silent iron accumulation, suppressing your body's cleanup systems while accelerating cellular aging. The fix isn't statins or seed oils. It's resistance training, brief intense exercise, fasting, and managing your iron. Every study points to the same conclusion: aging is a lifestyle disease, not a birthday disease.
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@MitchWils1 @scaling_shields listen - he just sells double the supply for july and bingo august - off
sinple
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@scaling_shields Takes august off in Costa del Sol. Busiest month of the year by a country mile. Doubtful
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seen this firsthand
my mates uncle supplies paper napkins to 800 restaurants across the costa del sol
€11M last year
from napkins, a warehouse, a van and a phone
met him at a bbq in marbella last summer
looked like a retired PE teacher
polo shirt
sandals
drives a 2019 volkswagen
i asked my mate what his uncle does
"logistics"
"what kind"
"he delivers napkins and paper towels to restaurants"
i laughed
"hes worth about €8 million"
i stopped laughing
later that night his uncle started talking
"we buy napkins from one factory in valencia. €0.003 per napkin. we sell them to restaurants for €0.01. thats a 230% markup on something people blow their nose with and throw in the bin"
"but the real money isnt the margin. its the reorder"
every restaurant orders napkins
every week
without thinking about it
"we have 800 restaurants. average order is €180/week. 52 weeks a year. do the maths"
800 × €180 × 52 = €7.4M
plus paper towels toilet rolls takeaway containers and cleaning supplies
€11M total
i asked if restaurants ever switch suppliers
"why would they? its napkins. nobody has a meeting about napkins. nobody puts napkins out to tender. the chef calls me on monday like hes done for 9 years and says 'same again' and i deliver on wednesday"
zero churn on a product people throw away without thinking
thats the moat
"what about competition?"
"who wants to compete in napkins? every kid on the internet wants to build an app or start an agency. nobody wakes up and says i want to be the napkin guy. thats why ive had no real competitor in 22 years"
i asked why he doesnt scale to other regions
"why? i work 4 days a week. i drive my daughter to school every morning. i take august off. i made €11M last year selling things people wipe their mouth with and throw on the floor. what would scaling get me? stress?"
he took a sip of wine and said the thing i think about constantly
"the best business in the world is selling something nobody thinks about to customers who never switch. the moment your business is interesting enough to talk about at dinner someone will try to copy it. i sell napkins. nobody copies me. nobody wants to"
there are families all over europe running businesses like this
invisible
boring
printing
while everyone fights over the same saturated markets trying to look impressive online
attention attracts competition
obscurity attracts profit
Sam Parr@thesamparr
My buddy runs a company helping manufactures implement ai. He showed me the leads he’s getting. It’s nuts. Family businesses I’ve never heard of making $100m a year. They know the need ai but no idea what to do. Crazy how much momey is out there
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Grand Performance, a Twin Cities cycling shop that's been on St. Paul's Grand Avenue for more than 40 years, is winding down operations and will close in the coming months. bizjournals.com/twincities/new…
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@eurofounder €3.50 is after taxes so if i was you i would ask for €8
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@MrStillwater @alt_w_v_g @johnkissinger is that the same poor that are doordashing every meal of theirs
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@alt_w_v_g @johnkissinger Why won’t Republicans introduce a national citizenship ID that is easily accessible and free to all citizens like every other 1st world democracy has? Because disenfranchising the poor is the point.
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Let me make sure I understand this correctly
To buy a beer: ID
To board a plane: ID
To pick up my kid from school: ID
To get a fishing license: ID
To enter my own office building: ID
To buy cold medicine: ID
To open a bank account: ID
To rent a car: ID
To check into a hotel: ID
To prove to my bank that I'm human: 14 minutes and a CAPTCHA
To vote for the leader of the free world: nothing
If A = B and B = C then A = C
That's the transitive property
I learned it in 7th grade
Apparently not everyone did
My analyst could build a better system in an afternoon
And he's not even that good
Make common sense common again
Plz fix. Thx.
Sent from my iPhone
GIF
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I was recently hiring a CFO for my startup
Interviewed a perfect candidate
10 years experience, ex-Google, exactly the right profile
There was one big problem though
He was a white male
"Matthias, we need to look at the bigger picture here" my HR director said
I wholeheartedly agreed
We hired a black lesbian woman instead
She doesn't have any experience in finance but that doesn't really matter
I urge every European founder to put diversity first
This is the only way to truly grow
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@StarTribune Anyone who thinks a piece of paper is going to protect them from someone who intents harm is either a fool, a retard or both!
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Killings of 2 Minnesota women raise questions about strength of protection orders startribune.com/killings-of-2-…
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cryptodebutante🔺 รีทวีตแล้ว

Submitted: Minneapolis residents file formal complaint against homes displaying F*CK ICE signs:
“The frequency of these signs is very prominent in South Minneapolis—especially in areas with no ICE activity. This isn’t about just one house. They are highly visible and can be seen by children,” the tipster said.
The city’s zoning department is now involved.


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My brother called me today
He needed €500 for his little son surgery
“Of course, we’re a family” I said
Then, I sent him a loan agreement, with 5.3% interest, and 12-month repayment schedule
“Are you serious, my son is in the hospital now” he called me back angry
I told him the European Central Bank doesn’t lend without terms, and neither do I
He hung up and borrowed from our mother instead
She didn’t even ask for collateral
That woman has zero financial literacy
You can’t just give out loans without proper documentation
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Perfect Sunday evening with my wife:
> No dinner outside (restaurants close on Sundays)
> Cook potatoes with bread (German tapas)
> Share a bottle of wine (€3.49 from Aldi)
> Watch a documentary about climate change
> Pause movie to let wife text her boyfriend goodnight
> Initiate intercourse at 9:35pm
> Finish intercourse at 9:38pm
> Set alarm for 5:45am (my commute is 1h 40m)
> Sleep at 10pm after my skincare routine
I absolutely love my European life
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@SeligerGrants @LasVegasFill did you even read what you wrote
you don’t boil the potatoes or they come pre-boiled - “if you are careful shopper you can SOMETIMES find t-bones porter houses inexpensively”
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@SeligerGrants @LasVegasFill it definitely didn’t take 15 minutes and porterhouse is not $10/lbs
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@LasVegasFill I did just about the same thing on my Weber in my backyard using a 24 ounce porterhouse I bought from my local supermarket for $10 a pound with rosemary from my garden smashed potatoes with chives for my garden etc cost about 20 bucks and took 15 minutes
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