eksogen

Prisen for å være tro mot deg selv er alltid høy

❤️1 4 1 3 ❤️ open.spotify.com/track/4fU3fPvh…

Scandinavian winters are so dark, so draining, that when spring comes one becomes manic with joy. Even though it happens every year, one is left overwhelmed by the sense that they had forgotten it was possible to feel this good.

Two doses of magic mushrooms degraded my sperm count from the 99.6th percentile to the 77.7th. This may be a first-in-human observation. Context: we ran the most quantified magic mushroom (psilocybin) experiment ever conducted. We were asking if psilocybin is a longevity therapy. After seeing the data, we think it is (see reply post for the experiment summary). Also, like most things biology: the results are complicated. My data suggests that the magic mushrooms (psilocybin) negatively impacted my fertility markers. Before the first psilocybin dose my motile sperm count was at 99.6th percentile for men under 25 years of age, it dropped to 77.7% and partially recovered to 89.3% following the first dose, and second doses, compared to the same age cohort (numbers compare similarly to my age cohort as well). 3 days following my second dose (first dose 25 mg, second dose 28 mg) . Motility: dropped 51% . Total count: almost unchanged, dropped by 2% . Total motile count: dropped 52% . Normal morphology: dropped by 50% 20 days post 2nd dose, the pattern continued, with typical latent effects on total sperm counts Motility: recovered back to -2% of pre-psilocybin baseline: . Total count: dropped by 38%, latent effect. . Total motile count: remained inhibited at -39% of pre-psilocybin baseline, (despite motility normalizing, due to the total count drop) . Morphology normalized to -10% of baseline levels. Reduction in free testosterone might have contributed to the effect. While total serum testosterone increased by 30% 3 days following the 2nd dose (neither FSH or LH were meaningfully affected either), and continued to be at 11% above baseline, SHBG increased by 37%, SHBG binds testosterone and reduces its bioavailability and activity. My free testosterone (direct) showed 24% and 23% drops at 3 and 20 days post 2nd dose. In light of the neuroplastic, well-being, brain reset, and systemic metabolic and anti-inflammatory benefits, the trade-off is probably worth it. Especially considering that the magnitude of inhibition has no meaningful effect on actual fertility (total motile counts above 50 million are still on the safe side). This is a first-in-human observation, to our knowledge there is no published human clinical study demonstrating that psilocybin diminishes male fertility markers. General mechanistic evidence exists for recreational and psychoactive drugs possibly inhibiting fertility markers due to their effects on the hypothalamus-pituitary-adrenal axis and general hormonal reset.  Yet no direct evidence for psilocybin or other similar psychedelics inhibiting fertility markers exist. A potential mechanism for the immediate inhibition of motility could involve direct serotonergic signaling in sperm. Human sperm express multiple serotonin receptors, including 5-HT2A, and one recent study found that a 5-HT2A antagonist reduced sperm motility, suggesting that 5-HT2A may regulate motility. Psilocybin is known to bind 5-HT2A with high affinity.

@spacepunk @bryan_johnson Do it anonymous?

@bryan_johnson Being rich is wild because you can just live streamed doing schedule I drugs and people think its cool (it IS cool for the record, but I wish lower status people were offered the same affordances)

Livestreaming 5-MeO-DMT this weekend… what should I expect?

@fasc1nate Getting a Coca plant this Sunday actually

Cocaine was once promoted as a medical “miracle drug,” and Sigmund Freud became one of its most famous early researchers and users. In the early 1880s, he wrote enthusiastically about its supposed benefits in what later became known as the Cocaine Papers. Whether Freud himself was addicted remains a matter of speculation. The drug, derived from the South American coca plant, was first isolated in the mid-1800s but didn’t gain major medical attention until the 1880s. At that time, many physicians experimented with it without understanding its dangerous side effects or addictive potential. Freud likely began using cocaine while working at the Vienna General Hospital. Inspired by reports of its energizing effects on exhausted soldiers, he obtained a sample for research and personal use. In letters to his fiancée, he described the drug’s mood-lifting effects and his intention to praise it in print. In 1885, Freud published On Coca, arguing that cocaine had significant medical value. He continued using it into the 1890s, stopping only after nearly harming a patient while under its influence. His early enthusiasm mirrored that of many doctors who were slow to recognize the risks. By the turn of the century, rising addiction rates made the dangers impossible to ignore. Cocaine appeared in countless unregulated tonics and sodas, prompting growing public concern. Pharmacists pushed for restrictions, and in 1914 the United States outlawed the drug under the Harrison Narcotic Act. Cool historical photos: bit.ly/4cFoZT1

@liminal_warmth i smoked salvia and "woke-up" in a beautiful garden next to a mask merchant. apparently i was trying on a mask that made me experience this world. i told him that was cool and he asked me if i wanted another try. i said yes, put the mask back on and woke up back in this reality.

@appropriert33 Har du høy status blir du behandlet annerledes enn lav status i helsevesenet

Ingen ligger en måned på psykiatrisk mottaks enhet med mindre de ikke er farlige for personalet på DPS klinikker. Selvmord og depressive tilstander behandles vanligvis poliklinisk eventuelt med innleggelse ved DPS. Men virker ikke som det er blitt kommunisert. Mulig Jagland har skadet seg alvorlig 🤷‍♂️ Hvor er Jagland?

Cocaine use soars in Norwegian cities Cocaine use in Oslo has nearly tripled in five years, and Norway tops Europe in amphetamine use. nordictimes.com/world/cocaine-…

@MortenMSB Viktig årsak til noe av det du beskriver er at jobbene til sjøs har blitt færre, og at arbeidslivet i dag for ufaglærte ofte er dårligere enn bakover i tid Tok jobb som lettmatros som 22 åring, flott arbeid

En vinter var Lofotfisket så elendig at "lotten" på oss "mannan" endte på lusne 25000,- ! Da dro jeg rett til Vardø og skar steinbitfilet på samlebånd ved gamle FinoTro-fiskerianlegg i Vardø. Jobba 12/12 sju dager i uka et par måneder. Bodde på brakke. Brydde jeg meg? Nei. Jeg bare jobba på…

@TweeterReynolds Grats Peter

54 years after Mother Nature first turned me on, at last I'm legal! I'm back as a permanent resident in the UK and I am now prescribed #cannabis as medicine by a specialist doctor. This is a momentous occasion for me as I have spent more than half my life working towards the law reform we achieved in 2018. It's great to be back home! #drugspolicy

@EFCevie Got room for one more? Look how happy u both look

Riskkapitalister står på kö för att investera i psykedeliska droger – i Nederländerna öppnade ett kryphål i lagen för en guldrush. svd.se/a/oEny7a/guldr…

@bryan_johnson Paw Patrol

I'll be live streaming the 5-MeO-DMT. Am putting together the line up. Who should we have call in?

rus er viktig nok for arbeiderpartiet, bare det er øl og fotball: nrk.no/norge/store-i-…

@IverNstad83446 @jhlrsn Problemet med krig er at de som støtter den er villig til å bruke hva som helst av penger på den.

@eksogenisk @jhlrsn Går fort et par løk per skattebetaler å handheve forbudet, rein galskap