Jake Brenner

Can resilience be learned? A new study from @Princeton researchers finds that prior stressful events can help build resilience. @PrincetonNeuro research.princeton.edu/news/can-resil… or see the article @Nature nature.com/articles/s4158…

@FrontPharmacol Excited for @drkatermd, neonatologist and first author here, developing #nanomedicine for infectious diseases. Many worry about side effects of nanoparticles, but, Surprisingly, nanoparticles actually augment neutrophils' phagocytosis of bacteria.

New Research: Nanoparticle-Induced Augmentation of Neutrophils’ Phagocytosis of Bacteria frontiersin.org/articles/10.33… #pharmacology

Nanomedicine Kung-Fu! 🥷 Our Advanced Materials (@AdvSciNews) paper from yesterday is featured in @PennMedNews, showing conjugated Factor I can act like a Kung-Fu Master to protect #nanoparticles & gene therapy from complement. #nanomedicine #GeneTherapy pennmedicine.org/news/news-rele…

Wow, we in #nanomedicine have so much to learn from nature, and our colleagues studying exosomes / extracellular vesicles. Great leadership by @H_Ghandehari & @ADDReditors to put work like this in ADDR.

@MJMitchell_Lab @NanoLetters @MagBillingsley @carlhjune @ACS4Authors @pennbioeng Great paper, and likely the future of cell therapies. Super impressive work @MagBillingsley and @MJMitchell_Lab!

Check out our latest on the cover of today’s issue of @NanoLetters led by @MagBillingsley in collaboration w @carlhjune’s lab on orthogonal DOE methodology to create new mRNA lipid nanoparticles for engineering CAR T cells for cancer immunotherapy! Link: pubs.acs.org/doi/10.1021/ac…

As an ICU doc, I've cared for 100s of #COVID19 patients. Currently, many have TWO Viruses: #SARS-CoV2, AND a Mental Virus of false beliefs that vaccines + science = evil. We must show compassion for anti-vaxxers, as their mental virus was created in a lab: #FoxNews.

Anti-vaxxers: This does NOT indicate danger of #COVID19 #vaccines. Vaccines go into your shoulder muscle, where there is no pre-existing inflammation. Our paper focuses on a risk for FUTURE applications of LNPs to express proteins to fix ARDS, sepsis, etc. #VaccinesSaveLives

Psyched about paper with close friend & colleague Hamideh Parhiz and @WeissmanLab: Lipid #nanoparticles (LNPs) saved the world as #COVID19 vaccines & hold great promise. But when host has pre-existing inflammation at site of delivery, LNPs worsen it 10x! pubmed.ncbi.nlm.nih.gov/34953981/

Excited the full version of our Advanced Materials paper just published! Factor I conjugation to #nanoparticles blocks complement activation, prolonging NP half-life, improving organ- & cell-targeting, & preventing CARPA. & super EASY! onlinelibrary.wiley.com/doi/10.1002/ad…

Our paper in Advanced Materials (@AdvSciNews ), using Factor I to stop complement's deleterious effects on #nanomedicine, was a true team effort, & built on great work by Simberg, Moghimi, Szebeni, etc! Happy to help others use it for their nanomedicines! onlinelibrary.wiley.com/doi/10.1002/ad…

CARPA is an #anaphylaxis-like reaction caused when complement reacts with nanoparticles (or therapeutic proteins). In sepsis model mice, #nanoparticle CARPA caused massive shock & cerebral hypoperfusion, but conjugated Factor I totally prevented this.

Our new paper in Advanced Materials (@AdvSciNews) conjugates Factor I to #nanoparticles to stop complement from attacking. Even +PEG, complement opsonizes #nanoparticles ➡️ phagocyte+RES uptake, ⬇️1/2life, +CARPA. Factor I destroys complement! onlinelibrary.wiley.com/doi/10.1002/ad… 🧵below

Cute! Our lab makes #nanomedicine onesies for all our colleague-babies born into the #nanomedicine family! We've made for @KaraSpillerLab, @WeissmanLab, & we're branching into puppies (sorry, kittens). Get one for a colleague (I mean their baby, we don't condone adult onesies 🤪)

Cool use of RBC-hitchhiking (RH) to treat #ARDS (lung inflammation that kills in #COVID19), which is my favorite disease (yes, all docs have fav diseases to battle 🥷🔫⚔️). Smart to use positively charged #nanoparticles to help adsorb onto RBCs. Just watch out for complement.

Ton of fun moderating a session w V Muzykantov, @WillemNANO, Jamie Spangler at IMES, hosted by @KaraSpillerLab. #nanomedicine hit only base-hits & strikeouts for 40 yrs, but hit a grand slam by partnering w immunology. Lessons from this & the other success, mRNA-LNPs?