Mengtong (Tom) Duan

25 posts

Mengtong (Tom) Duan

@mtduan

Graduate Student @Caltech, BS @UWBiochemistry. Membrane traffic and fusion, acoustic biomolecule engineering.

Pasadena, CA เข้าร่วม Kasım 2012

63 กำลังติดตาม60 ผู้ติดตาม

Mengtong (Tom) Duan รีทวีตแล้ว

Mikhail Shapiro (same on bsky)@mikhailshapiro·12 Tem

SEMPER out at @CellSystemsCP! 📜 What is SEMPER? A way to tunably co-express multiple genes from the same mammamlian mRNA. The final paper adds a model & expr. of a two-chain antibody w/heavy-light tuning. Congrats @mtduan, @ishaanjdev and colleagues! sciencedirect.com/science/articl…

Mikhail Shapiro (same on bsky)@mikhailshapiro

Can you express multiple genes from a single mRNA at programmable ratios without long intervening sequences or peptide overhangs? 🤔 Yes, with SEMPER! 😉 Congrats @mtduan, @ishaanjdev and coauthors on this new tech for mammalian synbio & gene therapy. biorxiv.org/content/10.110…

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Mengtong (Tom) Duan รีทวีตแล้ว

Journal of Cell Biology@JCellBiol·13 Mar

SM proteins are essential SNARE cofactors for membrane fusion. The ER–Golgi SM, Sly1, has several different activities reported to promote fusion. Here, Duan, Merz et al @UW test each function in parallel genetic and biochemical reconstitution experiments. hubs.la/Q02plnQy0

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Mengtong (Tom) Duan รีทวีตแล้ว

Journal of Cell Biology@JCellBiol·13 Mar

The series of events leading from vesicle tethering to assembly of pre-fusion SNARE complexes is poorly understood. Duan, Merz and coworkers @UW discovered a latent, short-range tethering activity in the essential SNARE chaperone Sly1 hubs.la/Q02pljJx0 #Trafficking

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Mengtong (Tom) Duan รีทวีตแล้ว

Mikhail Shapiro (same on bsky)@mikhailshapiro·14 Tem

Thanks @NatureBiotech for highlighting our work on this month's cover! Congrats to @robertchurt, Marjorie Buss, @mtduan and colleagues, and the talented @maayanvisuals who created the artwork. nature.com/articles/s4158…

Mikhail Shapiro (same on bsky) tweet media

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Mikhail Shapiro (same on bsky)@mikhailshapiro·27 May

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Addgene@Addgene·24 Oca

If light scattering in tissue is causing issues in your research, perhaps it's time to consider acoustic reporter genes (ARGs). @mikhailshapiro's lab shares the newest generation of bacterial and mammalian ARGs in our latest blog post. hubs.la/Q01y-Gr60

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Mengtong (Tom) Duan รีทวีตแล้ว

Sir Douchebag@SirDoucher·8 Tem

@rainyalexandria Saw a high-speed chase with a guy in a silver truck pulled into the PCC parking lot going about 40 miles an hour and made a hard right into the parking building on the on the south parking structure by Delmar/ Hill. Literally over 30 cop cars surrounded it.

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Mengtong (Tom) Duan รีทวีตแล้ว

Mikhail Shapiro (same on bsky)@mikhailshapiro·2 Kas

Going from GFP to EnhancedGFP made fluorescent reporters much more useful. Excited to take a similar step with second-generation Acoustic Reporter Genes based on #gasvesicles. Congrats to @mtduan, @MarjorieBuss, @robertchurt et al on this updated preprint. biorxiv.org/content/10.110…

GIF

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Mengtong (Tom) Duan รีทวีตแล้ว

HHMI@hhmi_science·23 Eyl

HHMI News: We are proud to announce our 33 new #HHMIInvestigators. These individuals have the potential to make transformative discoveries over time and we look forward to seeing where their ideas lead them. bit.ly/3AE4OBs

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Harmit S. Malik@HarmitMalik·18 Şub

Lots of lucky folks are getting news about admission into grad school. Choosing the right mentor/ program can be a difficult but very important decision. Trust your intuition but get more info if needed; kindness is not sufficient but is necessary to be a good mentor. Good luck!

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Mengtong (Tom) Duan@mtduan·15 Ara

@macroliter @Merz I'm blushing 😊

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Jeremy Kamil is also @macroliter.bsky.social@macroliter·15 Ara

This right here is some [expletive!] truly incredible science from @mtduan & @merz. Deep dive into how Sly1 participates in membrane fusion.. integrates yeast genetics + in vitro biochemistry.. blows my mind.. Kudos to the authors! biorxiv.org/content/10.110…

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Mengtong (Tom) Duan@mtduan·18 Mar

Was afraid of this

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Mengtong (Tom) Duan รีทวีตแล้ว

Elinor Hortle 🐟🐀🔬🧫@ElinorHortle·16 Mar

I used to think there were 2 types of scientist: -Those who naturally had heaps of great ideas for new projects -Those who didn’t have that ability. I ‘knew’ I was the 2nd type & would never be a great scientist because of it. Ever felt the same? Read on 🧵#phdchat

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Geoff Bennett@GeoffRBennett·15 Mar

"Everything we do before a pandemic will seem alarmist. Everything we do after will seem inadequate." - Michael Leavitt, former HHS Secretary under President George W. Bush

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Mengtong (Tom) Duan@mtduan·13 Mar

So cool!

Lexi Walls@coronalexington

Amazing things @UWproteindesign @UWBiochemistry Here we check out what @Foldit players have come up with to help design binders against the SARS-CoV-2 receptor binding domain... goal is to block the interaction with human receptor ACE2! Thanks @ichaydon for the video magic!

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Mengtong (Tom) Duan@mtduan·13 Mar

Nicely formatted COVID-19 data aggregated from each state

The COVID Tracking Project@COVID19Tracking

If you are interested in using the data, you can. There's an API or you can just download a file (.csv). covidtracking.com/api/

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Mengtong (Tom) Duan รีทวีตแล้ว

rach_w@rachw852·9 Mar

@nytimes Same issue, Similar measures, Quite OPPOSITE comments from NYT! What better words than “double standards “?

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Mengtong (Tom) Duan รีทวีตแล้ว

Liz Specht@LizSpecht·7 Mar

I think most people aren’t aware of the risk of systemic healthcare failure due to #COVID19 because they simply haven’t run the numbers yet. Let’s talk math. 1/n

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Mengtong (Tom) Duan@mtduan·2 Mar

@Merz I can hear the clicking from Pasadena :D

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ค้นพบ

@ishaanjdev @UW @NatureBiotech @robertchurt @maayanvisuals @mikhailshapiro @rainyalexandria @MarjorieBuss