Ravi K. Patel

Steroids have *compartment-specific* effects in patients with COVID-19 ARDS! Results highlight importance of studying injured organs directly when possible @NatureComms with Lucile Neyton, @sciRPatel, @GabiFragiadakis and colleagues nature.com/articles/s4146…

📢Greetings! We are accepting submissions for 'Systemic immune response through a multi-omic lens' @FrontImmunol Please share this with anyone working on #systemsImmunology #immunology #multiomics #integrativeAnalysis #infectiousdisease #autoimmunity frontiersin.org/research-topic…

I am excited to share that our #IMPACC paper - Integrated longitudinal multi-omics study identifies immune programs associated with acute COVID-19 severity and mortality - was recently published in @jclinicalinvest. jci.org/articles/view/… #SystemsBiology #Bioinformatics [1/5]

@NatRevImmunol publishes an article highlighting findings of our recent publication. science.org/doi/10.1126/sc…

Excited to share our manuscript on single-cell and spatial multi-omics of anti-integrin therapy in ulcerative colitis (UC) #Ack1" target="_blank" rel="nofollow noopener">nature.com/articles/s4146…. This work was led by @ElviraMennillo, in collaboration with @alexis_combes, @GabiFragiadaks, and @drAOPisco 1/8

@WillySanchez_23 The human data is now available on GEO.

@sciRPatel Hello Ravi, congrats for the paper. Can these cells have also helper roles for the new adaptive T cells produced after birth? Is your human data available to download on geo?

How do neonates with primitive immune system survive in the world? We found: (1/5) @SciImmunology (in Rudd & Grimson labs; with Neva & Connor, fellow Tweeters @Oyeb2003 @CybelleTabilas @kristel_yee @eliataitwojno) #SingleCell #multiomics #neonatalImmunity scim.ag/5Z2

Not at all jumping on the AI rodent band wagon, but delighted to announce the publication of our paper in @MucosalImmunol about why you lose your appetite when you have a cold pubmed.ncbi.nlm.nih.gov/38382577/ Including the coolest experiment I have ever done

@NarfGb @SoothSpider I haven't worked with a cross-talk between those two. But this paper talks about NF-kB-controlled transcriptional regulation of miR-146 via NF-kB predicted binding sites in miR-146's promoter. ncbi.nlm.nih.gov/pmc/articles/P…

If newborn's immune system does not require (or depend on) antigen recognition, then why do we inject them with substances (for their own good) that generate antibodies? 🤔 📄 science.org/doi/10.1126/sc… 🧵 threadreaderapp.com/thread/1761568…

New research in mice finds that neonatal CD8+ T cells can undergo rapid chromatin remodeling, which supports their innate-like functions. Read more: scim.ag/607 @Cornell @CornellCFI

@SciImmunology This paper is beautiful ➡️ science.org/doi/10.1126/sc… To be paired with this vintage 💎 science.org/doi/10.1126/sc…

A new @SciImmunology study describes why a subset of T cells behaves in a way that is more similar to innate immune cells, rather than responding like normal adaptive immune cells. Learn more: scim.ag/603

@WillySanchez_23 That may be possible, but I am not sure if we are equipped to test that with the current data. The human data is expected to be available soon.

@Jeff_Mold @PGTimmune That's super interesting! Is this a published work or are you currently working on it?

@Jeff_Mold @PGTimmune Unfortunately, we don't have TCR data on these samples, but it's an interesting idea. CoNGA seems like a very useful tool! Thanks for sharing.

@Jeff_Mold Just checked, it (cluster A5 in Fig 7E) is not, but the clusters F6 (fetal) and N4 (neonatal) seem IKZF2+KLRC2+. I wonder if the absence of these markers in A5 is due to dropouts in scRNA-seq.

@vipintukur Thank you for posting about our work. It's an honor. We are very excited to see the implications of our findings.

These findings provide support for the layered immune hypothesis and indicate that the CD8+T cell compartment is more functionally diverse than previously thought. 10/10 science.org/doi/10.1126/sc…

During COVID pandemic, many were surprised by the apparent lack of illness in infants. Experts believed that a newborn's immune system was an immature version of an adult's, but a new work shows that newborns' T cells outperform those of adults at fighting off infections 1/

@MoreauGabarain @vipintukur That is a very interesting insight. I have moved on to working on human diseases, but the Rudd lab is interested in following up on these cells in adults, and it would be interesting to see if their counts correlate with the host's ability to produce Abs at population-scale.

@vipintukur I remember that kids don’t convert infections to antibodies as much, so it is more difficult to assess infection from abs. I think this illustrates it. Also I wonder about adults who have kept maybe some of these features. Thanks.

@BagaiDr Thank you for sharing our work. It's an honor. We are very excited about the implications of our findings.

Innate-like CD8+ Tcells were also present in both adult mice and humans, multiple layers of defense may exist within adult naïve Tcell pool.

gene regulatory basis of bystander activation in CD8+ Tcells; T cells are primarily activated in response to antigen recognition via Tcell receptor (TCR), undergo TCR-independent “bystander” activation in response to certain cytokines. science.org/doi/10.1126/sc…