Dr. Scott C. Ritchie

@asda can't help but notice you've removed the per unit pricing on your price tags - setting every item to have a unit size of one cannot be compliant with legislation

@HMRCcustomers To confirm: if foreign royalties are excluded from the Self Employment section, then my annual turnover is less than the reporting threshold; i.e. I would thereby only owe tax on the foreign royalties, not the additional income.

@sritchie73 In that case, please continue to report the foreign royalties under the foreign royalties section. Don't include them on the Self Employment section, otherwise the income will be counted twice. Nancy

@HMRCcustomers query when filling out self assessment: does income from foreign royalty payments count towards your annual turnover in the self-employment section?

@HMRCcustomers In past years I've only had the foreign royalties, so these have been reported under the foreign royalties section. When excluding the foreign royalties, the consultancy income is below the self-assessment reporting threshold.

@HMRCcustomers No foreign tax already deducted. I'm using self-employment as a catch-all for miscellaneous additional income that are unconnected to each other. This year I have a mix of UK income and foreign income from consultancy as well as foreign royalties.

@HMRCcustomers Should I instead file these foreign royalties under foreign income? This leads to the correct total income calculation of employment income + self employment turnover. 3/3

@HMRCcustomers By double counted, I mean the total income is calculated as employment income + self-employment turnover + foreign royalties. 2/3

Check out the latest developments of all things @PGSCatalog, out now in @NatureGenet (🔗: rdcu.be/dVakA )! In this paper we describe big increases in the data content (and diversity) and our tool for PGS calculation (github.com/PGScatalog/pgs…).

New manuscript "Addressing the credibility crisis in Mendelian randomization" is out at @BMCMedicine: bmcmedicine.biomedcentral.com/articles/10.11…. We discuss the explosion in MR studies, and what can be done by authors and editors/reviewers to improve the quality of published MR research. Thread:

I genuinely think RAP is not a bad idea for lots of analyses but 1) this explicitly kills off lots of integrative work where you want to join your data with UKBB but can’t upload it to a cloud 2) immediate rule change with no grace period is baffling community.ukbiobank.ac.uk/hc/en-gb/commu…

New preprint: We introduce MrDAG the first causal graphical model for Mendelian randomization (MR) to detect dependency relations within multiple exposures and within multiple outcomes to pinpoint which exposures cause disease biorxiv.org/content/10.110… Follow 🧵 for more. 1/

Congrats @ceclindgren! How lucky our field is to have you! 🌟#eshg2024

The Polygenic Score Catalog: new functionality and tools to enable FAIR research medrxiv.org/content/10.110… PGS calculator nextflow pipeline for polygenic score calculation github.com/PGScatalog/pgs…

Session towards #equity in genomics calling for large-scale African data collection for PRS #eshg2024

.@konradjk #eshg2024: Biobanks allow us to do "all by all" analyses, where you test the millions of genetic variants against thousands of phenotypes. Points to work with UK Biobank, specifically Pan-UKB (pan.ukbb.broadinstitute.org) and Genebass (app.genebass.org).

Exciting plans for the next gnomAD (v5) release, including integration of >400K diverse genomes from the All Of Us program, plus federated model to integrate data from national projects around the world (including Australia!). #eshg2024

Keep this in mind when indicating that "the variant was not present in general population databases". Maybe your patient's population is underepresented. Slide from @ksamocha #ESHG2024

How well do EHR-based scores predict disease onset compared to PGS? Can we predict disease onset in Finland using EHR-scores trained in the UK or Estonia? To find out what our @intervene_eu study discovered, come see our poster at #ESHG2024 on 3.6. at 15:45

Delighted to be in Berlin for #eshg2024! My team at the Centre for Population Genomics in Australia is looking for a senior computational biologist - if this is you, and you’re interested in relocating to Sydney, Melbourne, or NZ, I’d be happy to chat! populationgenomics.org.au/careers/