Trefely Lab

We have an exciting postdoc opportunity at the interface of metabolism and epigenetics! 🔥🧬 The project will investigate novel metabolic factors driving diabetic cardiomyopathy🫀, and test targeted dietary interventions 🍽️ For more detail and to apply: babrahaminstitute.livevacancies.co.uk/#/job/details/…

Calling metabolism enthusiasts looking for a PhD opportunity! We have an exciting project in partnership with DefiniGEN Applications close Nov 24th findaphd.com/phds/project/i…

@JuliannaSupplee @WellenLab @MarmorsteinLab Congratulations @JuliannaSupplee 🎉 Beautiful work

Happy to report that our paper, where we grapple with the mystery of ACLY splice isoforms, is finally out! jbc.org/article/S0021-… @WellenLab @MarmorsteinLab

📣Only 1 week left to submit an abstract for the UK's leading #immunometabolism event! #UKimmunomet24 will be packed with cutting-edge #research, plenty of networking & 'Bright Sparks' sessions for #ECRs 🌟 Submit your abstract by Friday 15 March 👉bit.ly/3TUBIKl

@doc_jlmeier @therealdiehllab @uofupharmacy 🙌

@irene_zorzan @AmyWilkinson25 @RuggGunnLab Congrats! 👏

Very excited to share our latest review on epigenetic regulation of early human embryo development! Thank you to @AmyWilkinson25 and @RuggGunnLab for delightful discussions and pleasant writing, and to reviewers for great feedback!

@WellenLab @BMBGGUPENN Congratulations Joyce! 🌟

@MathiasWenes @MiglioriniDenis @ArberCaroline @AlisonJaccard @PCHo_Lab @UNIGEnews @OncoUNILCHUV Congrats 👏

@AlisonJaccard Congrats!

📣Our paper is out 🥳 ➡️ nature.com/articles/s4158… We discovered that IDH2-mediated reductive carboxylation of glutamine epigenetically dictates effector T cell differentiation.

@DPhaz Congrats 🙌

Great to see this published- very proud to have contributed to this study. Congrats to Alice and thanks to all collaborators. Very excited to find out more about these novel genes that regulate Glut4 responses

@propionylCoA Congratulations Mary 👏🌟💫

I was awarded this year's UCLA Dr. Ursula Mandel Fellowship!

@AZadoorian22 @NatureRevEndo @rob8yang @ximingDu @UNSWBABS @UNSWScience @UNSW A great resource, congrats @AZadoorian22 @ximingDu and @rob8yang 👏

Want to know the latest about #LipidDroplet biogenesis and functions in health and disease? Check out our @NatureRevEndo paper published online today! rdcu.be/dcODg Thanks @rob8yang for the absolute privilege and joy of writing this with you and @ximingDu!🧵

Good morning all! A very Ac-CoA-rich summary of papers in #cancermetabolism and #mitochondrialbiology is out now, don't miss it: biomed.news/bims-camemi/20… @Bims_BiomedNews “The truth is not always beautiful, nor beautiful words the truth.” ― Lao Tzu

@Gerta_Hoxhaj @AranyLab @mzspectrum @WellenLab Thank you 😊

@trefely @AranyLab @mzspectrum @WellenLab Congrats, Sophie!

Can histone deacetylation fuel acetyl-CoA metabolism? We teamed up with Ioana Soaita @AranyLab @mzspectrum @WellenLab to answer this question. jbc.org/article/S0021-…

@PatVargaWeisz @AranyLab @mzspectrum @WellenLab Thank you!

@trefely @AranyLab @mzspectrum @WellenLab Nice work!

So the contribution of deacetylation to whole cell acetyl-CoA metabolism appears limited 🥲Although the contribution may vary across subcellular compartments. Variation in the extent of deacetylation between different histone lysine sites suggests selectivity in this response:

We didn't detect any release into extracellular acetate, so we checked 13C-labeling. We found that up to ~10% of the acetyl-CoA pool was derived from deacetylation, and this label was transmitted downstream into (iso)butyryl-CoA!

Our data are consistent with a model where acetate is preferentially mobilized to maintain other acetylation events (such as shown recently by Mendoza et al @berger_lab @GarciaLabMS) pubmed.ncbi.nlm.nih.gov/35061542/