Hongyuan Rob Yang

Thanks to @AZadoorian22 for finishing up this review. Lipid droplets are connected with many disease conditions. Here we summarize the latest on the biogenesis and functions of lipid droplets. We discuss a key role for lipid droplets in alleviating cellular stresses.

With so many great reviews on LDs already out, do we need another? Sarah @cohenlaboratory & I were approached by @NatRevMCB to organize a review on LD heterogeneity and inter-organelle contacts...topics often in reviews, but not a focus. Fun project! nature.com/articles/s4158…

The NHMRC yesterday announced final allocations for the year. The 2025 success rate for Ideas grants was 10%, Investigator grants 13%, and Clinical Trials 9%. Australia's total spend on healthcare and technology innovation in medicine and biotech from the Medical Research Endowment Account and Medical Research Future Fund this year will equate to the cost of 0.004 submarines. We're spending more on a single submarine than we'll spend on medical research in 30 years. Medical research matters. A clever country invests in the things that matter.

@DrZhenqiLiu thanks🤝

@rob8yang Nicely done. congrats!

We wrote a Perspective on the Cover story below. Check it out here science.org/doi/10.1126/sc… Adipocytes have developed a unique regulatory mechanism to produce giant, unilocular lipid droplets.

Great to see you. Also a wonderful visit. I have more scientific friends in Dallas than any other city on this planet.

We built upon a key discovery made by @KivancBirsoy and unveiled additional mechanisms for regulating lipid synthesis. CHP1 promotes lipid droplet growth and regulates the localization of key enzymes for triacylglycerol synthesis | PNAS pnas.org/doi/10.1073/pn…

@Roy_Lab_Thinks What about the current financial year? What exactly is the next cycle? Thanks

If you think the troubles at NIH does not affect you, you just need to wait. Due to multi-year funding, NINDS will be able to fund 40% fewer grants next cycle...even if budget stays same. Yes, message from one of the highest levels. Talk to Congress, that's the only way now.

Thanks to @pnas for a nice commentary on our recent work by @LabVanni Toward a molecular logic of lipid droplet heterogeneity? | PNAS share.google/RBrrQE3o0942xa…

Glad to see this online. From a random control experiment， we unexpectedly noticed that CIDE proteins and LD-localized ORP proteins cannot coexist on LDs. Through a series of experiments, we show that ORP2/5 keeps CIDE proteins away from LDs by depleting LD surface PI(4)P.

Dr. Jack Hu (胡仕新): “More than 40 years ago, I came to America to pursue a dream, arriving at the @UMich with a small suitcase and a thirst for learning. But never in my wildest dreams I’d imagine that I would became the chancellor of @UCRiverside ” 👍 latimes.com/california/sto…

@gfairn @DalMedicine @DalPathology Congratulations

Hot off the press at NCB. S1P carried by HDL initiates signaling that leads to changes in ER-PM contact sites, accelerating the movement of cholesterol into human adrenal cortical cells and hepatocytes. @DalMedicine @DalPathology nature.com/articles/s4155…

@amtya21 @JCellBiol Congratulations. But you forgot the first study linking phosphatidic acid, seipin and lipid droplets journals.plos.org/plosgenetics/a…

Excited to present first publication from the Joshi lab, now in @JCellBiol. Here, we show that phosphatidic acid regulates Pex30 distribution at ER subdomains for lipid droplet biogenesis by binding to dysferlin domain. rupress.org/jcb/article/22…

Online today in @Nature - our latest study led by superstar postdoc @GillesRademaker detailing the role of PSCK9 in driving sterol dependent metastatic organ choice in pancreatic cancer nature.com/articles/s4158… full text available here 👉 rdcu.be/em0VG and thread 👇

@JudithSimcox @Cell_Metabolism @_JessDavidson @HHMINEWS @UWBiochem Congratulations

Thrilled to have our story on the regulation of lysosomal lipids out in @Cell_Metabolism! The work was led by two outstanding grad students @_JessDavidson and Raghav Jain probing mechanistic control of energy expenditure @HHMINEWS @UWBiochem

See you in Spain

@ZhouLabUCR Huge Congrats!

Very honored to be elected an AAAS Fellow! I want to express my heartfelt gratitude to all of my mentors, colleagues, and mentees. Thank you all for your support and contributions!

Pending editorial decision

Moments after you agree to write a review

Well done, Dongyin and Xiaoqin.

A typical paper today