Lee

My travel app Pinr is now available on Google Play Store! Download from getpinr.com. iOS coming soon 📍

@katieMum @SkyNews Show us where the Red Cross said this Kathleen

@SkyNews You obviously ‘forgot’ to mention the Red Cross confirmed the baby was healthy when handed over …

Gaza toddler released from Israeli custody with suspected torture wounds trib.al/g1SOaOz

They put cigarettes into this toddler's legs to force confessions from his dad

@bridgemindai The only reason I even still have my pro plan is for UI, but once Codex gets better at that I'll have absolutely no use for Claude

Just cancelled my $200/month Claude Max subscription. Rate limits lowered dramatically out of nowhere. 529 overloaded errors daily. Hit my 5 hour limit in under an hour. Multiple days of outages this week. Claude Opus 4.6 is the best coding model when it works. The problem is it hasn't been working. Switching to Codex with GPT 5.4 as my main driver. Better rate limits. More reliable. Actually available when I need it. I don't want to leave Claude Code. I've built BridgeMind with it. But I can't build a company on infrastructure I can't depend on. Anthropic, fix the reliability. Fix the rate limits. I'll come back the day you do.

@zellieimani Except he has sent no such tweet

@MrNick1417 @rorynotsorry Nope, don't use that

@HackneyManLee @rorynotsorry How’s about Test. Flying with that too?

Most of this guys information is common sense... but he does get one thing wrong (which I expected) "Never check your GLP1s" "Peptides are fragile" Heating and freezing does not irreversibly destroy the peptide structure... maybe multiple cycles will eventually cause some degradation, but it's something that you don't have to worry about. Sources: Interviews with two heads of laboratories that test peptides for a living. Also personal experience traveling with GLP1s 220 days a year all over the world. Always checked in my luggage, and accidently freezing them several times, and leaving them at room temperature for days on end. Also, I think some peptide group actually sponsored a test as well. Maybe pepchat... cant remember. Repeat after me: Peptides are not that fragile. Don't sweat it. True things: TSA cares more about your ice pack than your peptides. Leaving peptides at room temperature isn't that big a deal (but refrigerator is still better). Sorry Doc... but the whole warning about fragile peptides thing is a Drug Companies being to lazy to do the real testing and being conservative than based on actual science. So is storage shelf life as well.

@rorynotsorry Thanks Rory. Yeah I began rethinking my original plan and figured I don't want to rush to 8mg and then plateau and have to go higher, so I figured staying on the lower doses as long as I'm seeing results might be the better approach like you said 👌🏾

The official titration schedule was to stay at four weeks for each of these. Then there was also a 6 mg increment. The best dosage is the one that works the best with appetite while not having side effects. My biggest recommendation is to consider split dosing. Instead of starting off at 2 mg once a week, do 1 mg twice a week. Different people have different sensitivity as well. I would say the 4 to 8 mg range is where most people are going to find it the most effective for losing weight. You should consult your doctor.

@rorynotsorry Is there a dosage strategy you recommend for newbies? I started on 2mg this week and was initially planning to titrate from 2mg ⏩4mg ⏩8mg in about 3 weeks, based on the clinical trials. But I'm now wondering if it's better to stay at 4mg longer?

@CAMELCASTOff Are they still together?

I appreciate the 99% of people on this post who understood it. The other people who need it spelled out for you (like my old friend from this post). Well, I am praying for yall.

One of my roughest memories is my gym buddy venting to me about his wife. He said that him and his wife hadn't had sex in 5 years. I asked if she ever goes anywhere for days. He said yeah, her cousins house every weekend. I asked him if she's celibate. He said no. I just paused and stared at him. Watching him do the math and have the realization was rough. I watched the light leave his eyes in real time.

@sorb2o @HanaHoops

@HanaHoops “wtf do she know bout cameras”😂

Wait a damn minute

@stablegeniuspro Except for outliers, in a calorie deficit you'll at best maintain muscle, but many will lose some muscle

“Calorie restriction causes muscle loss I need retatrutide!” Have you considered lifting heavy weights in a deficit you goyish piece of shit?

@splucas22 @CaitlinClark22 "Lebron and his spray painted hair will be remembered as pure garbage"

@HackneyManLee @CaitlinClark22 Sorry...truth hurts. Lebron and his spray painted hair will be remembered as pure garbage in a league that had been built by Magic, Bird and Jordan. When his Diddy tape comes out you will pretend you had always hated him.

The KING👑 … Shot by ME

@dylangonzalez21 @CaitlinClark22 Pacers fans are down so bad they're wanting pics of "Jay Huff"

@CaitlinClark22 Caitlin I NEED to know if there’s a Jay Huff post coming

@splucas22 @CaitlinClark22 "king of what?...flopping after zero contact?"

@CaitlinClark22 king of what?...flopping after zero contact? King of frauds who are juiced up on HGH and steroids? King of players forcing the NBA to give their bush league sons a contract they don't deserve?

Look at the 3 countries that voted against

@fdzmurillo @investseekers UBT251 sounds promising. It's worth noting that their phase 2 trial was conducted with a predominantly Chinese participant pool whereas Reta was done with a more diverse pool in the US.

"$LLY is seen as having the stronger pipeline." Let's test that against the data from this week alone. $NVO UBT251 (triple agonist): 2.16% A1c reduction in 24 weeks. $LLY retatrutide (triple agonist): 1.9% in 40 weeks. $NVO Wegovy pill: 16.6% weight loss, FDA approved, 600K Rx. $LLY orforglipron: 11.2%, not approved, delayed to April 10. But the real risk nobody is pricing into $LLY is structural. Orforglipron is a small molecule. No absorption enhancer. It needs high systemic doses to work. That means heavy hepatic metabolism via CYP3A4. Pfizer already learned this lesson the hard way: lotiglipron — same approach (small molecule, high dose, no delivery platform) — was killed for liver toxicity. Danuglipron was killed for drug-induced liver injury. Two candidates, same problem. Orforglipron has dodged the liver signal so far. But William Blair flagged that GI adverse events at high dose are NOT tapering off after titration — unusual for GLP-1s. Discontinuation rates run up to 9.7% vs 4.9% for oral semaglutide. And this is a drug patients take every day, for life. Now compare $NVO's approach: SNAC optimizes absorption in the stomach. The peptide reaches therapeutic levels with lower systemic exposure. Less hepatic load. Proven safe across 5+ years of Rybelsus data and now the Wegovy pill. And here's what the market hasn't figured out yet: SNAC doesn't just work for semaglutide. It works for any peptide. • Semaglutide oral → SNAC → approved • Amycretin oral → SNAC → in development • UBT251 oral → SNAC → potential future • Insulin oral → SNAC → Novo already explored this • Any future peptide therapeutic → SNAC This isn't about obesity anymore. Every peptide-based therapy in medicine — cancer peptides, mRNA-encoded peptides, hormonal therapies — faces the same delivery problem: the GI tract destroys peptides before absorption. SNAC solves that. For all of them. And $NVO owns it. The $2.1B Vivtex deal (Feb 2026) for next-gen oral biologics delivery confirms Novo sees SNAC as a platform far beyond GLP-1. So the real comparison isn't "$LLY pipeline vs $NVO pipeline." It's: one company has molecules. The other has molecules AND the only proven oral delivery platform for peptide medicine. Patented into the late 2030s. $LLY at 32x with liver risk, inferior oral data, and no delivery platform. $NVO at 14x with FDA approvals, 600K Rx, SNAC, and a triple agonist that beats Lilly's in half the time. Which pipeline is stronger? $NVO $LLY #SNAC #GLP1

No quick fix for $NVO. Growth pressures are becoming more structural than temporary. Revenue is expected to stay roughly flat around DKK 300B from 2024 to 2027. Price pressure in the US is significant, and volume growth takes time to offset it. The competitive picture is shifting: • $LLY is seen as having the stronger product and late stage pipeline • Oral GLP 1 launches are turning into a price driven race • More players are entering, moving the market from duopoly toward broader competition Even strong early demand for oral Wegovy is unlikely to move the needle near term due to lower pricing. The key issue is that obesity is already becoming a price and volume market. That is a very different setup from what Novo has historically operated in. Uncertainty remains around how pricing evolves and how quickly competition intensifies, especially with Lilly’s orforglipron expected soon. Link to article (in Danish): ugebrev.dk/ledelse/intet-… #stocks #Investing

@Shreyas49793920 @AnthropicAI @claudeai @DarioAmodei I remember when Antigravity did his back in January and it made me switch to Claude and Codex. I hope the Claude issue is just an innocent error

2140+ paying users complaining about Anthropic secretly reducing its usage limits for Claude last week. This is what you call a SCAM in 2026. @AnthropicAI @claudeai The usage exhaustion below is within 1 prompt (No Code). More on: reddit.com/r/ClaudeCode/c… #claude #claudecode

@WealthChakraa @Softnessa_ You ai people need to get lost

@Softnessa_ the way you handled that 🔥 dude literally just unplugged your phone. didn't ask. didn't wait. just took it and you responded with "are you okay" first giving him a chance to get it when he didn't, you made your point and that was it. no drama. no screaming. just done

I was charging my phone at the airport. This guy unplugged mine and started plugging in his. I just watched him. Then I said, “Are you okay?” He goes, “My phone is dead.” I unplugged his. Slowly. Maintained eye contact. “So is your awareness.” He laughs awkwardly, “I just need a few minutes.” I said, “And I need you to try that somewhere else.” Plugged mine back in. He didn’t reach for it again.

Heartbreaking 💔 - Israeli forces extinguish cigarettes on Palestinian child’s leg An 18-month-old Palestinian child, Jawad Abu Nassar, was subjected to severe abuse by Israeli forces in an attempt to force a confession from his father, according to Palestine TV. The infant was later handed over to the Red Cross after approximately 10 hours, bearing injuries that medical sources said included burns and puncture wounds. Reports indicated that cigarettes had been extinguished on his leg and a sharp object inserted into it. The incident took place near the Maghazi refugee camp, where the child was separated from his father, Osama Abu Nassar, during gunfire at a checkpoint. The father remains in Israeli custody.