Dylan Ryan

Very excited to announce that the first paper from the lab is now live @NatureComms #mitochondria #immunometabolism This work was led by postdoc @EloiseMLMrqs with many important contributions from all of our co-authors. New insights since the preprint (summarised below): 1) Biphasic IFN-I expression 2) Late phase IFN-I is mediated by mitochondrial nucleic acid signalling incl. cGAS-STING pathway 3) Reduced IL-1 and COX2 is mediated in part by autocrine IFN-I 4) Systemic IFN-I signalling in different tissues, notably the kidney, in vivo Please check it out! nature.com/articles/s4146…

📢 Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️ biomed.news/bims-imicid/20… Interesting finding: Macrophage anti-bacterial activity is controlled by adenylate kinase 4–mediated mitochondrial DNA synthesis

MITF programs macrophage iron homeostasis to drive gut-liver inflammatory axis in early life dlvr.it/TRY5dq

Structures of respiratory supercomplexes and ATP synthase oligomers in mammalian mitochondrial inner membrane | Nature Communications nature.com/articles/s4146…

Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson’s disease models: Cell cell.com/cell/fulltext/…

New! Online now: Psoriasis modulates inflammatory bowel disease risk and intestinal epithelium lipid metabolism via IL-1β-producing macrophages dlvr.it/TRYyb5

Nature research paper: Ageing promotes metastasis via activation of the integrated stress response go.nature.com/4b4nGxZ

We are excited to present our new study @Nature, led by @DrDrCox and performed in collaboration with the lab of @MaayanLevyPhD, in which we explore the impact of gut-brain axis aging on cognitive decline. nature.com/articles/s4158…

Huge congratulations to lead author Qinli Sun on this fantastic work in @nature! An IL-2–TGFβ surrogate agonist from the Garcia Lab induces antigen-specific peripheral Tregs and promote immune tolerance in models of ashtma, gut inflammation, and EAE: rb.gy/0qjs1o

Natural maternal immunity protects neonates from Escherichia coli sepsis #citeas" target="_blank" rel="nofollow noopener">nature.com/articles/s4158…

Pluripotent stem-cell-based screening uncovers sildenafil as a mitochondrial disease therapy: Cell cell.com/cell/fulltext/…

Pluripotent stem cell-based drug discovery uncovers sildenafil as a treatment for mitochondrial disease | medRxiv share.google/4KVND4iHzipMAQ…

Last call for abstracts — deadline today (March 9)! Submit now for the chance to present your research to a global audience united in advancing the study of mitochondrial biology. hubs.li/Q045_3j60 @CellPressEvents #CSMito2026 #Glasgow #Scotland

Blood offers a window on systemic metabolic health — a founding principle of clinical biochemistry. How much information about human aging is encoded in a drop of blood? Profiling the RBC proteome in >13,000 donors reveals genetically encoded aging clocks predicting RBC quality

What if immune cells don't need to destroy a cell to learn from it? Max Krummel's talk at #AACRio26 quietly reframed how we think about myeloid cell surveillance. His team observed macrophages picking up tiny pinched-off vesicles from living cells — a trogocytosis-like "nibbling" — without killing them. The sampled material then traveled through a distinct intracellular pathway, bypassing the usual route to lysosomes. The striking finding: this live-sampling pathway drove efficient MHC class I presentation and CD8+ T cell stimulation — arguably better than classical phagocytosis. The implication? Live-cell sampling may be the default mode of immune surveillance, with phagocytosis as the exception. And tumors may hijack this very pathway to drive T cell exhaustion. It's the kind of fundamental biology that quietly reshapes everything downstream. 🔬 🔗 Read ACIR's full #AACRio26 special feature → bit.ly/4sjXuoL #CancerImmunology #Immunotherapy #AACR #MyeloidCells @MaxKrummel

Last 2 weeks of literature on #Mitochondria in #Health & #Disease! 🤍💚 biomed.news/bims-mitdis/20… biomed.news/bims-mitdis/20… @Bims_BiomedNews @mitoscientist @gavinmcstay2 @MitoAging @Mito_News Vit B2 and B3 nutrigenomics reveals a therapy for NAXD disease cell.com/cell/fulltext/…

Red blood cells make up 83% of the cells in the human body. Mature RBCs lack nuclei (no gene expression) and organelles, and >90% of their dry weight is hemoglobin. Yet we have lacked a clean, contamination-free map of their proteome. Until now. biorxiv.org/content/10.110…

Excited to share an amazing video on the NLRP3 inflammasome pathway generated by talented Ann from the Iwasa lab @janetiwasa @Ann_HuiLiu. It shows the real cryo-EM structures of the pathway from #NLRP3, #ASC, #caspase-1, #GSDMD, #IL-1b, to #NINJ1. #cryoem @LeXiao17 Enjoy

📢Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️ biomed.news/bims-imicid/20… Interesting finding: The glycolytic metabolite phosphoenolpyruvate restricts cGAS-driven inflammation to promote healthy aging.

@ClareBryant13 🤣

@RyanLab_TCD In your dreams Dylan Ryan the Welsh are coming back!!!!!!!!

TRIFosomes found😀. Very proud of our team’s work to identify endogenous TRIFosome. Surprisingly whilst TRIFosomes activate NFKB, IFN signaling is from monomeric or dimeric TRIF. doi.org/10.1126/sciadv…