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Harmless Frog
23.4K posts
Harmless Frog
@FrogHarmless
A monster from the what-is-true dimension. N&R: 🇵🇱🇻🇦 L: 🏴🇵🇱🇳🇴🇷🇺🇳🇱
شامل ہوئے Ekim 2019
228 فالونگ555 فالوورز
@paleonormie What I don't understand is why she's hiking in her underwear.
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man a lot of people aren't familiar with the PCT huh
hundreds of young women solo hike it every year lol long distance trails aren't a random wander through unpopulated places, there are a dozen other hikers at every stop
Mittens@JUSTcatmeme
She’s probably going to disappear in some strange fashion and no one will ever see her again.
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@xmjEE Hahaha. They needed an order of magnitude more to knock over Iraq. Iran is bigger and mostly mountains, and there's no active civil war to takes sides in.
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Harmless Frog ری ٹویٹ کیا
Sorry I haven't been posting much. Been very busy. Please take this ominous photo as an apology
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@kitten_beloved Well, the guy you QT'd explains in a followup post. His case seems reasonable to me.
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If she's actually attractive and not a total bummer to be around then this lady is probably quite a catch, why are so many guys on here so insistently gay about this kind of thing
This is plenty young enough to have a couple of kids which is all most people want
Daniel@danielgothits
Lol it’s 2026 and women still don’t understand what makes a guy want to marry someone
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Harmless Frog ری ٹویٹ کیا
Harmless Frog ری ٹویٹ کیا
It is past midnight here now
Happy Easter, friends! He is Risen
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@MichaelAlbertMD That is a fairly high baseline.
Do you have pre- and post- ApoB, too?
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1/ I take a statin and ezetimibe every day.
My LDL in 2018: 127 mg/dL.
My LDL today: 41 mg/dL.
Here's exactly what changed — and why the evidence earned my confidence.🧵
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I'm 36. I'm a physician. I take a statin—and ezetimibe—every day.
No symptoms. No cardiac history. Just an honest read of the evidence.
Here's what I found—and why I stopped waiting for a reason to act.
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@MrBeigeShiba Seems to me that smokeless powder firearms are just more practical. You can bottle up a lot of energy-as-solid-fuel in a brass case easily. You can't bottle up a lot of energy-as-gas-pressure easily.
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@MichaelAlbertMD @drpablocorral There clearly are other mechanisms to deal with the problem, not just receptor-mediated clearance. 🤷♂️
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@drpablocorral How do we reconcile this finding with disease reversal at levels below 55 mg/dL?
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👆 Rethinking “Normal” LDL-C: A Physiological Mismatch
📍 LDL receptor kinetics are not aligned with current clinical definitions
📍 Half-maximal receptor-mediated LDL uptake occurs at ~30–40 mg/dL (Km range), far below what we label as “acceptable”.
📍 Binding affinity tells an even harsher story
1️⃣ LDL–LDLR interaction (Kd) suggests significant receptor engagement already at ~10–15 mg/dL. Above these levels, clearance becomes progressively inefficient
2️⃣ Additional LDL is no longer matched by proportional receptor-mediated uptake → plasma accumulation becomes inevitable.
3️⃣ Modern “normal” LDL-C (~100 mg/dL) exists in a biologically saturated system
4️⃣ This is not physiological—it is compensated pathology.
Atherosclerosis, then, is not an anomaly
5️⃣ It is the predictable consequence of operating chronically above receptor capacity.
📍 Take-home message
We did not adapt physiology to modern LDLc levels
We adapted our definitions to a chronically saturated system.
doi.org/10.1042/bj3230…
@society_eas
@nationallipid
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@KirkegaardEmil Well, yes, where it's permitted, people use abortion as a contraceptive.
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The most interesting thing about this is how little it matters for the fertility rates we see.
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@Italian347 Regardless of the total numbers, killcam videos starring US soldiers aren't going to be very popular back home.
Iraq 2.0 seems implausible - too much mountains and drones. Afghanistan 2.0 too - no massive local allied army to give air support for.
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The guys who were saying this would be just a quick bombing campaign with no broader war attached now say that this will be just a quick war on the ground with no very large casualty numbers attached
Christian Heiens 🏛@ChristianHeiens
A US invasion of Iran is not going to produce the tens of thousands of dead Americans that third-world propagandists continue to claim it would. There's no universe where the United States loses militarily to Iran in a conventional way. The entire Iraq and Afghanistan wars combined amounted to less than 8,000 killed over a 20-year period. What's likely going to happen is the US suffers a few hundred casualties taking Kharg Island and any other coastal facilities the Pentagon wishes to use as a bargaining chip in peace negotiations. That isn't the problem. The problem is that such a ground offensive will be used to further demoralize the Right and bring the cultural Marxists back into power. People who would love nothing more than to reopen the border, import another 20 million third-worlders, trans kids, and leverage state power to discriminate against White men will not openly campaign on these things. They'll campaign on the Virginia model. They'll talk about "affordability" and "being against the war". Only after being swept into power on the back of public anti-war sentiment will they begin to implement the various civilizationally destructive policies of gay race communism that we're all now all too familiar with. This war with Iran is stupid not because we can't win, but because it will be used to destroy the Right and bring those who hate this country and its people back into power.
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@ethanjweiss Very interesting. Guess the really big, TG-rich ApoB particles aren't causing the plaque.
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I am surprised that nobody is surprised by these results. It feels quite earth-shattering to me but what do I know?
At 6 months, olezarsen reduced triglycerides by 63.9%, remnant cholesterol by 71.9%, and apolipoprotein B by 16.0% over placebo, with no difference in LDL-C.
And yet no difference in plaque at all at one year? None? So many questions and so few answers but I think this is one of the most interesting null results I have seen in a long time.
Circulation@CircAHA
#SimPub #ACC26 In CCTA substudy of Essence-TIMI 73b (RCT of olezarsen vs. placebo in patients with hypertriglyceridemia), no difference in non calcified, coronary plaque volu... @marstonMD @maciejbanach @AndreZimerman @michael_t_lu @BrianBergmark @BudoffMd ahajrnls.org/4m4ZwHK
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Hello today my special interest is COMMUNITY BUILDING
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@jonatanpallesen Pretty sure you'd have to pretty much enslave some people to lift them out of poverty. 🤔
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Denmark is the highest taxed country in the world.
Which is understandable with these politicians
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@AStratelates Human-written unit tests aren't trustworthy. Since LLMs imitate human code, their output will also imitate its faults.
This is fine, IMO. Relying on automated tests alone is just insane. They're just there as a screen and interface locks.
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@Valen10Francois I don't think that's a fair characterization of the phenomenon. PA is just one of the litmus tests of who has US-wide winning potential. How they vote isn't actually causally upstream of presidential election outcomes beyond the actual EC votes they affect.
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A good reminder to Europeans (hmm hmm Germany) that if your defense policy relies on a few thousand voters in Pennsylvania then it's not a very good policy
Basil🧡@LinkofSunshine
Honestly this is insane (Pennsylvania)
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@The_Petrichory On the one hand, sure. On the other hand, I somehow doubt USA is capable of sufficiently disrupting their electrical grid (due lack of will, mostly). If all else fails, they can fall back to diesel generators.
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At some point Trump's just going to make good on his threat to bomb their power infrastructure. Guess they'll have to paddle a rowboat out with a tin cup in hand to collect.
Insider (World News)@InsiderWN
#BREAKING: Iran says they will keep charging vessels a fee for safe passage through the Strait of Hormuz.
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Harmless Frog ری ٹویٹ کیا
A few of you have asked to see a bit more Frog content...
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