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The ON/OFF dichotomy is fundamental to visual processing. In a new study led by Flori Soto, we identify a conserved molecular mechanism establishing the OFF pathway. rdcu.be/eikoa
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Daniel Kerschensteiner
239 posts
Daniel Kerschensteiner
@KLabVision
Prof @WUSTL. Vice-Chair @WustlDOVS. Co-Director #WashUNeuroPhD. To understand, preserve, and restore vision.
Saint Louis, USA شامل ہوئے Ağustos 2021
371 فالونگ650 فالوورز
Daniel Kerschensteiner ری ٹویٹ کیا
A @NeuroCellPress paper led by Kushal @UCBerkeley, Nicole&Victoria @UCSF in full collaboration with @shekharlab, Molecular and spatial analysis of ganglion cells on retinal flatmounts identifies perivascular neurons resilient to glaucoma sciencedirect.com/science/articl… #retina #MERFISH
Neuron@NeuroCellPress
Online now: Molecular and spatial analysis of ganglion cells on retinal flatmounts identifies perivascular neurons resilient to glaucoma dlvr.it/TMbNkk
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Daniel Kerschensteiner ری ٹویٹ کیا
Finally it's out! nature.com/articles/s4158… Thanks to Felix Baier, Karl Farrow and Hopi Hoekstra! And a big thank you to all the co-authors, reviewers, host institutes and funding sources! @BramNuttin, Arnau Sans Dublanc, Chen Liu, Victoria Tong, Julie Murmann and Keimpe Wierda
Katja Reinhard@KatjaReinhard
How flexible are essential innate behaviours and their underlying neural circuits? @Felix_Baier and I, with @HoekstraLab and @FarrowLab, addressed this question by studying the #evolution of threat avoidance in sister-species of Peromyscus mice. biorxiv.org/content/10.110…
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Daniel Kerschensteiner ری ٹویٹ کیا
We found that endogenous ligand for GPR139 is opioid peptide dynorphin. With this, GPR139 may not be an orphan any more but the 5th opioid receptor. Heavy lift by talented Xiaona Li with great thanks to all who contributed!
nature.com/articles/s4146…
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Daniel Kerschensteiner ری ٹویٹ کیا
Join us in congratulating professor Susan K. Dutcher, PhD, on her election to the National Academy of Sciences. Her groundbreaking research on cilia is unlocking insights into chronic disease and continues to elevate WashU Medicine’s legacy of scientific excellence and impact.
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Daniel Kerschensteiner ری ٹویٹ کیا
65 years after Lettvin’s bug detector neurons in the frog retina, we revisit how the retina drives behavior—from reflexes to prey capture to brain-state modulation
New review with @AnnaIntegrated & Serena Riccitelli in Annual Review of Vision Science 👇
tinyurl.com/ymp3vs4d
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Daniel Kerschensteiner ری ٹویٹ کیا
ATLAS, a rationally designed transsynaptic tracer is out today! Plasmids will soon be available on @Addgene addgene nature.com/articles/s4159…
Many thanks to first authors Jackie Rivera and Haoyang Huang, and to collaborators, @blsabatini @Kanoski_Lab @vincentw_weng @beherring
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Daniel Kerschensteiner ری ٹویٹ کیا
Happy to share our recent work on a conductance that shapes substantially the output of rod photoreceptors.
The role of the Ca2+-activated Cl- conductance in the membrane potential and light response of mouse rods jneurosci.org/content/early/…
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Daniel Kerschensteiner ری ٹویٹ کیا
We have innovated design of templates for CRISPR/Cas9 editing which allows efficient introduction of epitope tags in vivo. It is a simple hack which we hope to be broadly useful. Work by talented graduate student Chuanping Zhao.
nature.com/articles/s4146…
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Daniel Kerschensteiner ری ٹویٹ کیا
1/ Why do late-stage cancer patients lose motivation & sink into apathy?
🔥Our new Science paper shows cancer activates a cytokine-sensing brain circuit to lower motivation.Great work by Aelita Zhu @sarahstarosta @Pignatelli_Lab @JanowitzTobias &team!🧵
🔗 doi.org/10.1126/scienc…
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Daniel Kerschensteiner ری ٹویٹ کیا
Our RUVBL2 paper is online published by Nature: trebuchet.public.springernature.app/get_content/8a…
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Daniel Kerschensteiner ری ٹویٹ کیا
Research from @KLabVision published in @PNASNews, reveals how mice use vision to #hunt! 🐭🔬
Jenna Krizan, PhD, and colleagues revealed that some neurons in the superior colliculus inherit their motion-sensitive signaling patterns from the #retina.
#eyes
ophthalmology.wustl.edu/the-role-of-di…
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Daniel Kerschensteiner ری ٹویٹ کیا
Our latest on GPCR function in the brain. We report that glutamate receptor mGlu4 needs to be properly positioned at synapses of cholinergic interneurons in NAc by cell adhesion molecule ELFN1 to regulate opioid reward.
pnas.org/doi/epub/10.10…
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Daniel Kerschensteiner ری ٹویٹ کیا
Excited to present the result of a fantastic collaborative effort - funded by the National Institutes of Health, including the NIH HEAL Initiative, to develop safer analgesic drugs.
nature.com/articles/s4158…
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Daniel Kerschensteiner ری ٹویٹ کیا
We must learn to showcase the practical significance of basic research, demonstrating how seemingly arcane investigations yield transformative applications, writes @tonyzador.
thetransmitter.org/outreach/how-t…
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Daniel Kerschensteiner ری ٹویٹ کیا
Here it is finally: Our mathematical methods book for life scientists! Aimed at advanced undergrads and beginning grad students, plus all those who want a deeper look at the math behind quantitative biology.
1/3
The MIT Press @mitpress.bsky.social@mitpress
@AlexBrostoff @kjuanitabrown 📘 Mathematics in Biology ✍ Markus Meister, Kyu Hyun Lee & Ruben Portugues A textbook for advanced undergraduate and graduate students across the biological sciences that provides a foundation for understanding the methods used in quantitative biology: mitpress.mit.edu/9780262049405/…
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Daniel Kerschensteiner ری ٹویٹ کیا
Excited to share our latest study! 🧠✨ We reveal how non-direction-selective retinal ganglion cells encode motion beyond their receptive field, relaying the unconventional signals to the brain. A new insight into multimodal neurons in visual processing!
pnas.org/doi/10.1073/pn…
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Daniel Kerschensteiner ری ٹویٹ کیا
Our paper, "The promise and peril of comparing fluorescence lifetime in biology revealed by simulations", is now on @eLife: doi.org/10.7554/eLife.…. Hope readers will use our package to design and interpret FLIM experiments rigorously, and also give us feedback.
Yao Chen@yaochen20
Interested in quantifying absolute levels of biological signals and comparing signaling dynamics across time and animals? Fluorescence lifetime, insensitive to sensor expression, could achieve this. Does this hold true in real biology experiments? Check out our manuscript. (1/8)
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Daniel Kerschensteiner ری ٹویٹ کیا
Our paper "GABAergic amacrine cells balance biased chromatic information in the mouse retina" is now published in @CellReports cell.com/cell-reports/f…
Anna Vlasits@AnnaIntegrated
Excited to share our new preprint where we uncovered how inhibitory interneurons in the retina process color information in their dendrites. A #tweetprint with authors @mkorympidou Sarah Strauss @TimmSchubert @kfrankelab @teulerlab @CellTypist biorxiv.org/content/10.110…
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Daniel Kerschensteiner ری ٹویٹ کیا
I am thrilled to share the published version of our study on how neuropeptide signals regulate feeding in the hypothalamus! We imaged endogenous peptide signals in subcellular compartments during behavior. Below is an updated summary: rdcu.be/dZlI3
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