JK Nandakumar lab

2.2K posts

JK Nandakumar lab

JK Nandakumar lab

@LabNandakumar

Professor @UMich_MCDB dept of @umichLSA College at the University of Michigan (@umich) Views/posts are JK's

شامل ہوئے Nisan 2019
463 فالونگ503 فالوورز
JK Nandakumar lab ری ٹویٹ کیا
Samrat Mukhopadhyay
Samrat Mukhopadhyay@SamratLabMohali·
Happy to share our community note published in Nature Communications. In this 14-page article (34 authors from 9 countries), we discuss current practices in biomolecular phase separation and hope it will be useful to the biomolecular condensate community. nature.com/articles/s4146…
Samrat Mukhopadhyay tweet media
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Bing Ye
Bing Ye@byneuron·
Tenure-track assistant professor position in neuroscience or physiology at University of Michigan LSA Molecular, Cellular, and Developmental Biology (MCDB) lsa.umich.edu/mcdb/news-even…
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Simanshu Dhirendra
Simanshu Dhirendra@simanshu·
BBO-10203 is currently being evaluated in the Phase 1 BREAKER-101 trial (NCT06625775) in patients with HER2+ and HR+/HER2- breast cancer, KRAS mutant colorectal cancer, and KRAS mutant non-small cell lung cancer.
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Simanshu Dhirendra
Simanshu Dhirendra@simanshu·
This publication describes how BBO-10203 disrupts the RAS–PI3Kα interaction without impairing insulin signaling, resulting in broad antitumor activity across multiple cancer models. It also shows enhanced efficacy in combination with other targeted agents.
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Miguel Godinho Ferreira
Miguel Godinho Ferreira@MGodinhoFerr·
Happy to share our new paper! 🎉 We show that #cGAS–#STING inflammation drives premature #aging in response to telomere shortening in #zebrafish. 🧬 Telomere-driven aging occurs in 2 stages: 1️⃣ Senescence, inflammaging, cancer 2️⃣ Genome instability, death tinyurl.com/34rhn67z
Miguel Godinho Ferreira tweet media
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Ming Li Lab@Umich
Ming Li Lab@Umich@MingLi_Umich·
New paper from the lab. We collaborated with the legendary Stuart Kornfeld lab to study the molecular mechanisms of how TMEM251/LYSET regulates the M6P pathway. Molecular Insights into the Regulation of GNPTAB by TMEM251 biorxiv.org/content/10.110…
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Simanshu Dhirendra
Simanshu Dhirendra@simanshu·
Our structural-guided insights contributed to the design of BBO-8520, a first-in-class dual inhibitor targeting both GTP-bound (ON) and GDP-bound (OFF) KRAS G12C. Excited to see this work now published in @CD_AACR! @FredNatLab @BridgeBioPharma
Elizabeth McKenna@ElizSMcKenna

Now online in @CD_AACR: Discovery of BBO-8520, a First-in-Class Direct & Covalent Dual Inhibitor of GTP-Bound (ON) & GDP-Bound (OFF) KRAS G12C - by Anna Maciag, James Stice, Bin Wang, @frankpmccormick, Pedro Beltran, et al. doi.org/10.1158/2159-8… @FredNatLab @BridgeBioPharma

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Kelly Nguyen
Kelly Nguyen@KellyTHD_Nguyen·
Last week, we said farewell to the first postdoc of our lab, George Ghanim @AutomneNine who will start his own lab at Princeton in 2025. We are proud of you and thankful for all your contributions. Please watch out for exciting future opportunities from the Ghanim lab!
Kelly Nguyen tweet media
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Miguel Godinho Ferreira
Miguel Godinho Ferreira@MGodinhoFerr·
“We highlight the differences between human and mouse telomere biology that may contribute to discrepancies between human diseases and mouse models. Finally, we discuss recent efforts to generate new ‘humanized’ mouse models to better model human telomere biology.” 👇
Nature Reviews Molecular Cell Biology@NatRevMCB

Now Online: Telomere function and regulation from mouse models to human ageing and disease go.nature.com/3D2Cu1m

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Abhishek Chatterjee
Abhishek Chatterjee@AChemSynBio·
Happy to share Elise and Tarah’s work on building a facile selection system to engineer E. coli leucyl synthetase for site-specific incorporation of many new noncanonical amino acids into proteins in eukaryotes, including ornithine and N-acetyl-methyllysine!
bioRxiv Synthetic Biology@bioRxiv_synbio

Optimized directed evolution of E. coli leucyl-tRNA synthetase adds many noncanonical amino acids into the eukaryotic genetic code ... biorxiv.org/cgi/content/sh… #biorxiv_synbio

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MCDB Michigan
MCDB Michigan@UMich_MCDB·
MCDB's Kozik Honored by Microbiology Society | U-M LSA Molecular, Cellular, and Developmental Biology (MCDB) lsa.umich.edu/mcdb/news-even…
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Molecular Cell
Molecular Cell@MolecularCell·
In our #RNA focus issue, we invited viewpoints from three groups on the controversy over PRC2-RNA interactions and asked how they might reconcile the findings on the topic. dlvr.it/TF7h5W dlvr.it/TF7h5h dlvr.it/TF7h6G
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Cornell University
Cornell University@Cornell·
Ratan Tata ’59, B.Arch. ’62, the university’s most generous international donor and one of India's most respected business leaders and philanthropists, passed Oct. 9. We will remember his legacy of transformative giving to Cornell. news.cornell.edu/stories/2024/1…
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Ci Ji Lim
Ci Ji Lim@cijilim·
1/8 ❄️🔬Excited to share our latest work published in @NatureComms! Led by @kaitlyn_m_abe and in colab with @GrantCryoEMLab, we've discovered a simple, cost-effective way to mitigate sample damage at the air-water interface during grid preparation. #CryoEM rdcu.be/dSWfn
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Vikas Navratna
Vikas Navratna@vikasnavaratna·
I've submitted my first ever tenure-track job application. Officially, I'm on tenure-track job market. My major interest is membrane protein structure & function. As a first-gen immigrant scientist, even being able to apply is a long way from a working-class family home in India.
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Tina Termini
Tina Termini@CterminiPhD·
Ladies who lead in diversity, equity, and inclusivity!!! Congrats on a well deserved honor, @TheKingLab ♥️🩸#ISEH2024
Prof Louise Purton@purton_louise

Celebrating Leadership in Diversity, Equity & Inclusivity @ISEHSociety #ISEH2024! Congratulations to @TheKingLab (middle) on being this year’s recipient, so highly deserved 🎉🎉🎉 Who is going to join inaugural recipient @CterminiPhD (left) & myself next year? Photo compulsory 😊

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دریافت کریں

@ScienceMagazine @Livermore_Lab @MGodinhoFerr @CD_AACR @BridgeBioPharma @AlbertW_Lab @RappsilberLab @NatureComms